Chance 1955 J Biol Chem-III

Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation: III The Steady State. J. Biol. Chem.

Chance B, Williams GR (1955) J. Biol. Chem.

Abstract: In a complex enzymatic sequence the site of action of substrates and inhibitors is clearly marked by the way they affect the steady state concentrations of the components of the system (1). Antimycin A, for example, inhibits respiration in the succinic oxidase system (2) and at the same time increases the steady state reduction of cytochrome b and decreases that of cytochromes c, a, and aa (3). In the oxidative phosphorylation system of liver mitochondria, phosphate and phosphate acceptors cause a considerable activation of respiration and may do so by a reversal of inhibitory reactions along the respiratory chain (4-6). Thus measurements of changes in the steady state of the members of the respiratory chain upon initiation and cessation of oxidative phosphorylation of ADP’ may identify sites in the chain where the phosphorylation reactions occur.

Labels:

Tissue;cell: Hepatocyte; Liver"Hepatocyte; Liver" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property. 

Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property. 

HRR: Theory