Difference between revisions of "Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum"
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|year=2015 | |year=2015 | ||
|event=Fatty Acid Oxidation O2k-Network Discussion Forum | |event=Fatty Acid Oxidation O2k-Network Discussion Forum | ||
|abstract=Fatty oxidation in permeabilised db/db mice muscle fibres, in Mir05 + Cr +37ยฐC. We found that ADP-stimulated respiration in presence of 0,02mM of palmitoyl-carnitine (OXPHOS) is very close to the non-ADP-stimulated respiration (LEAK state) when working with these conditions. (Values around 14 to 20 (pmol/s/mg w.t.) for | |abstract=Fatty oxidation in permeabilised db/db mice muscle fibres, in Mir05 + Cr +37ยฐC. We found that ADP-stimulated respiration in presence of 0,02mM of palmitoyl-carnitine (OXPHOS) is very close to the non-ADP-stimulated respiration (LEAK state) when working with these conditions. (Values around 14 to 20 (pmol/s/mg w.t.) for LEAK state and 15 to 24 (pmol/s/mg w.t.) for fatty acid triggered-OXPHOS). These data suggest either a very poor ability for this animal model to use palmitoylcarnitine or a very high LEAK state (or both!) | ||
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{{Labeling | {{Labeling | ||
|organism=Mouse | |||
|tissues=Skeletal muscle | |||
|couplingstates=LEAK, OXPHOS | |||
|substratestates=FAO | |substratestates=FAO | ||
|additional=Palmitoylcarnitine ย | |additional=Palmitoylcarnitine | ||
}} | }} |
Revision as of 16:10, 9 November 2015
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum |
Link: O2k-Network Discussion Forum
Chavanelle V (2015)
Event: Fatty Acid Oxidation O2k-Network Discussion Forum
Fatty oxidation in permeabilised db/db mice muscle fibres, in Mir05 + Cr +37ยฐC. We found that ADP-stimulated respiration in presence of 0,02mM of palmitoyl-carnitine (OXPHOS) is very close to the non-ADP-stimulated respiration (LEAK state) when working with these conditions. (Values around 14 to 20 (pmol/s/mg w.t.) for LEAK state and 15 to 24 (pmol/s/mg w.t.) for fatty acid triggered-OXPHOS). These data suggest either a very poor ability for this animal model to use palmitoylcarnitine or a very high LEAK state (or both!)
Labels:
Organism: Mouse
Tissue;cell: Skeletal muscle
Coupling state: LEAK, OXPHOS
Palmitoylcarnitine