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Difference between revisions of "Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum"

From Bioblast
(Created page with "{{Abstract |title=Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum |info=[http://www.bioblast.at/index.php/Talk:Fatty_acid_oxidation O2k-Network Discussion Forum...")
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|year=2015
|year=2015
|event=Fatty Acid Oxidation O2k-Network Discussion Forum
|event=Fatty Acid Oxidation O2k-Network Discussion Forum
|abstract=Fatty oxidation in permeabilised db/db mice muscle fibres, in Mir05 + Cr +37ยฐC. We found that ADP-stimulated respiration in presence of 0,02mM of palmitoyl-carnitine (OXPHOS) is very close to the non-ADP-stimulated respiration (LEAK state) when working with these conditions. (Values around 14 to 20 (pmol/s/mg w.t.) for leak state and 15 to 24 (pmol/s/mg w.t.) for fatty acid triggered-OXPHOS). These data suggest either a very poor ability for this animal model to use palmitoyl-carnitine or a very high leak state (or both!) ย 
|abstract=Fatty oxidation in permeabilised db/db mice muscle fibres, in Mir05 + Cr +37ยฐC. We found that ADP-stimulated respiration in presence of 0,02mM of palmitoyl-carnitine (OXPHOS) is very close to the non-ADP-stimulated respiration (LEAK state) when working with these conditions. (Values around 14 to 20 (pmol/s/mg w.t.) for LEAK state and 15 to 24 (pmol/s/mg w.t.) for fatty acid triggered-OXPHOS). These data suggest either a very poor ability for this animal model to use palmitoylcarnitine or a very high LEAK state (or both!)
}}
}}
{{Labeling
{{Labeling
|organism=Mouse
|tissues=Skeletal muscle
|couplingstates=LEAK, OXPHOS
|substratestates=FAO
|substratestates=FAO
|additional=Palmitoylcarnitine ย 
|additional=Palmitoylcarnitine
}}
}}

Revision as of 16:10, 9 November 2015

Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum

Link: O2k-Network Discussion Forum

Chavanelle V (2015)

Event: Fatty Acid Oxidation O2k-Network Discussion Forum

Fatty oxidation in permeabilised db/db mice muscle fibres, in Mir05 + Cr +37ยฐC. We found that ADP-stimulated respiration in presence of 0,02mM of palmitoyl-carnitine (OXPHOS) is very close to the non-ADP-stimulated respiration (LEAK state) when working with these conditions. (Values around 14 to 20 (pmol/s/mg w.t.) for LEAK state and 15 to 24 (pmol/s/mg w.t.) for fatty acid triggered-OXPHOS). These data suggest either a very poor ability for this animal model to use palmitoylcarnitine or a very high LEAK state (or both!)


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Organism: Mouse  Tissue;cell: Skeletal muscle 


Coupling state: LEAK, OXPHOS 


Palmitoylcarnitine