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Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum

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Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum

Link: O2k-Network Discussion Forum

Chavanelle V (2015)

Event: Fatty Acid Oxidation O2k-Network Discussion Forum

Fatty oxidation in permeabilised db/db mice muscle fibres, in Mir05 + Cr +37Β°C. We found that ADP-stimulated respiration in presence of 0,02mM of palmitoyl-carnitine (OXPHOS) is very close to the non-ADP-stimulated respiration (LEAK state) when working with these conditions. (Values around 14 to 20 (pmol/s/mg w.t.) for LEAK state and 15 to 24 (pmol/s/mg w.t.) for fatty acid triggered-OXPHOS). These data suggest either a very poor ability for this animal model to use palmitoylcarnitine or a very high LEAK state (or both!)


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Organism: Mouse  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 


Coupling state: LEAK, OXPHOS 


Palmitoylcarnitine