https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&feed=atom&action=history
Chicco 2023 MiP2023 - Revision history
2024-03-29T13:35:02Z
Revision history for this page on the wiki
MediaWiki 1.36.1
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=237310&oldid=prev
Tindle Lisa at 09:52, 30 March 2023
2023-03-30T09:52:51Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:52, 30 March 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2023 Obergurgl AT</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2023 Obergurgl AT</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|abstract='''Authors:''' [[Chicco Adam J]], [[Le Catherine H]], [[Mulligan Christopher M]], [[Whitcomb Luke A]], [[Evans Amanda E]], [[Routh Melissa A]], [[Sparanga Genevieve C]] <br></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|abstract='''Authors:''' [[Chicco Adam J]], [[Le Catherine H]], [[Mulligan Christopher M]], [[Whitcomb Luke A]], [[Evans Amanda E]], [[Routh Melissa A]], [[Sparanga Genevieve C]] <ins style="font-weight: bold; text-decoration: none;"><br></ins><br></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cardiolipin (CL) is a tetra-acyl mitochondrial phospholipid that supports the optimal function of several mitochondrial membrane proteins and processes. In the healthy mammalian heart, the majority of CL species contain four linoleate acyl chains (L4CL). A marked depletion of cardiac L4CL is paralleled by an increase in CL species containing docosahexaenoic acid (DHA) in hyperphagic obese (''Lep<sup>ob</sup>''; OB) mice despite no change in dietary fat composition [1], but the mechanisms and functional relevance of these changes are unclear. We hypothesized that this shift in CL composition results from increased activity of delta-6 desaturase (D6D), the rate limiting enzyme in the biosynthesis of DHA and conversion of linoleate into highly unsaturated ω-6 fatty acids, by altering the distribution of fatty acids available for CL remodeling. To test this, we administered the selective D6D inhibitor SC-26196 (100 mg/kg/d in chow) to 4-5 month-old OB or lean (C57Bl/6) mice for 4 weeks. As hypothesized, D6D inhibition reversed obesity-related changes in cardiac CL composition, restoring L4CL and DHA-enriched CL species to within 5 % of levels in lean mice, which paralleled reciprocal shifts in the linoleate and DHA levels of total myocardial phospholipids. Obesity-related decreases in cardiac mitochondrial respiratory control by ADP (with NS pathway substrates) and greater mitochondrial H<sub>2</sub>O<sub>2</sub> release during both LEAK and OXPHOS states were also abolished by D6D inhibition. These results corroborate accumulating evidence that cardiac CL composition is strongly influenced by the membrane fatty acids available for CL remodeling [2-3], and may impact the bioenergetic efficiency of mitochondrial respiration.<br></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cardiolipin (CL) is a tetra-acyl mitochondrial phospholipid that supports the optimal function of several mitochondrial membrane proteins and processes. In the healthy mammalian heart, the majority of CL species contain four linoleate acyl chains (L4CL). A marked depletion of cardiac L4CL is paralleled by an increase in CL species containing docosahexaenoic acid (DHA) in hyperphagic obese (''Lep<sup>ob</sup>''; OB) mice despite no change in dietary fat composition [1], but the mechanisms and functional relevance of these changes are unclear. We hypothesized that this shift in CL composition results from increased activity of delta-6 desaturase (D6D), the rate limiting enzyme in the biosynthesis of DHA and conversion of linoleate into highly unsaturated ω-6 fatty acids, by altering the distribution of fatty acids available for CL remodeling. To test this, we administered the selective D6D inhibitor SC-26196 (100 mg/kg/d in chow) to 4-5 month-old OB or lean (C57Bl/6) mice for 4 weeks. As hypothesized, D6D inhibition reversed obesity-related changes in cardiac CL composition, restoring L4CL and DHA-enriched CL species to within 5 % of levels in lean mice, which paralleled reciprocal shifts in the linoleate and DHA levels of total myocardial phospholipids. Obesity-related decreases in cardiac mitochondrial respiratory control by ADP (with NS pathway substrates) and greater mitochondrial H<sub>2</sub>O<sub>2</sub> release during both LEAK and OXPHOS states were also abolished by D6D inhibition. These results corroborate accumulating evidence that cardiac CL composition is strongly influenced by the membrane fatty acids available for CL remodeling [2-3], and may impact the bioenergetic efficiency of mitochondrial respiration.<br></div></td></tr>
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Tindle Lisa
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=237253&oldid=prev
Tindle Lisa at 14:19, 28 March 2023
2023-03-28T14:19:54Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:19, 28 March 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=US CO Fort Collins Chicco AJ</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=US CO Fort Collins Chicco AJ</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">|diseases=Obesity</del></div></td><td colspan="2"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">|topics=Fatty acid</del></div></td><td colspan="2"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::# Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::# Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:::: Corresponding author: adam.chicco@colostate.edu</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:::: Corresponding author: adam.chicco@colostate.edu</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Labeling</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|diseases=Obesity</ins></div></td></tr>
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|topics=Fatty acid</ins></div></td></tr>
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Tindle Lisa
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=237197&oldid=prev
Tindle Lisa at 13:02, 27 March 2023
2023-03-27T13:02:02Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:02, 27 March 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations <del style="font-weight: bold; text-decoration: none;">and acknowledgements </del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Chicco Adam J<sup>1-4</sup>, Le Catherine H<sup>2</sup>, Mulligan Christopher M<sup>3</sup>, Whitcomb Luke A<sup>1</sup>, Evans Amanda E<sup>1</sup>, Routh Melissa A<sup>2</sup>, Sparanga Genevieve C<sup>4</sup></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Chicco Adam J<sup>1-4</sup>, Le Catherine H<sup>2</sup>, Mulligan Christopher M<sup>3</sup>, Whitcomb Luke A<sup>1</sup>, Evans Amanda E<sup>1</sup>, Routh Melissa A<sup>2</sup>, Sparanga Genevieve C<sup>4</sup></div></td></tr>
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Tindle Lisa
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=237180&oldid=prev
Tindle Lisa at 10:17, 27 March 2023
2023-03-27T10:17:47Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:17, 27 March 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2023 Obergurgl AT</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2023 Obergurgl AT</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract='''Authors:''' [[Chicco Adam J]], [[Le Catherine H]], [[Mulligan Christopher M]], [[Whitcomb Luke A]], [[Evans Amanda E]], [[Routh Melissa A]], [[Sparanga Genevieve C]] <br></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract='''Authors:''' [[Chicco Adam J]], [[Le Catherine H]], [[Mulligan Christopher M]], [[Whitcomb Luke A]], [[Evans Amanda E]], [[Routh Melissa A]], [[Sparanga Genevieve C]] <br></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Cardiolipin (CL) is a tetra-acyl mitochondrial phospholipid that supports the optimal function of several mitochondrial membrane proteins and processes. In the healthy mammalian heart, the majority of CL species contain four linoleate acyl chains (L4CL). A marked depletion of cardiac L4CL is paralleled by an increase in CL species containing docosahexaenoic acid (DHA) in hyperphagic obese (''Lep<sup>ob</sup>''; OB) mice despite no change in dietary fat composition [1], but the mechanisms and functional relevance of these changes are unclear. We hypothesized that this shift in CL composition results from increased activity of delta-6 desaturase (D6D), the rate limiting enzyme in the biosynthesis of DHA and conversion of linoleate into highly unsaturated ω-6 fatty acids, by altering the distribution of fatty acids available for CL remodeling. To test this, we administered the selective D6D inhibitor SC-26196 (100 mg/kg/d in chow) to 4-5 month-old OB or lean (C57Bl/6) mice for 4 weeks. As hypothesized, D6D inhibition reversed obesity-related changes in cardiac CL composition, restoring L4CL and DHA-enriched CL species to within 5 % of levels in lean mice, which paralleled reciprocal shifts in the linoleate and DHA levels of total myocardial phospholipids. Obesity-related decreases in cardiac mitochondrial respiratory control by ADP (with NS pathway substrates) and greater mitochondrial <del style="font-weight: bold; text-decoration: none;">H2O2 </del>release during both LEAK and OXPHOS states were also abolished by D6D inhibition. These results corroborate accumulating evidence that cardiac CL composition is strongly influenced by the membrane fatty acids available for CL remodeling [2-3], and may impact the bioenergetic efficiency of mitochondrial respiration.<br></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Cardiolipin (CL) is a tetra-acyl mitochondrial phospholipid that supports the optimal function of several mitochondrial membrane proteins and processes. In the healthy mammalian heart, the majority of CL species contain four linoleate acyl chains (L4CL). A marked depletion of cardiac L4CL is paralleled by an increase in CL species containing docosahexaenoic acid (DHA) in hyperphagic obese (''Lep<sup>ob</sup>''; OB) mice despite no change in dietary fat composition [1], but the mechanisms and functional relevance of these changes are unclear. We hypothesized that this shift in CL composition results from increased activity of delta-6 desaturase (D6D), the rate limiting enzyme in the biosynthesis of DHA and conversion of linoleate into highly unsaturated ω-6 fatty acids, by altering the distribution of fatty acids available for CL remodeling. To test this, we administered the selective D6D inhibitor SC-26196 (100 mg/kg/d in chow) to 4-5 month-old OB or lean (C57Bl/6) mice for 4 weeks. As hypothesized, D6D inhibition reversed obesity-related changes in cardiac CL composition, restoring L4CL and DHA-enriched CL species to within 5 % of levels in lean mice, which paralleled reciprocal shifts in the linoleate and DHA levels of total myocardial phospholipids. Obesity-related decreases in cardiac mitochondrial respiratory control by ADP (with NS pathway substrates) and greater mitochondrial <ins style="font-weight: bold; text-decoration: none;">H<sub>2</sub>O<sub>2</sub> </ins>release during both LEAK and OXPHOS states were also abolished by D6D inhibition. These results corroborate accumulating evidence that cardiac CL composition is strongly influenced by the membrane fatty acids available for CL remodeling [2-3], and may impact the bioenergetic efficiency of mitochondrial respiration.<br></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><small></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><small></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># Han X, Yang J, Yang K, ZhongdancZ, Abendschein DR, Gross RW (2007) Alterations in Myocardial Cardiolipin Content and Composition Occur at the Very Earliest Stages of Diabetes: A Shotgun Lipidomics Study Biochemistry https://doi.org/10.1021/bi7004015 </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div># Han X, Yang J, Yang K, ZhongdancZ, Abendschein DR, Gross RW (2007) Alterations in Myocardial Cardiolipin Content and Composition Occur at the Very Earliest Stages of Diabetes: A Shotgun Lipidomics Study Biochemistry https://doi.org/10.1021/bi7004015 </div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{MiP header page name}}</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and acknowledgements ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and acknowledgements ==</div></td></tr>
</table>
Tindle Lisa
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=237179&oldid=prev
Tindle Lisa at 10:16, 27 March 2023
2023-03-27T10:16:57Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:16, 27 March 2023</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{MiP header page name}}</del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=US CO Fort Collins Chicco AJ</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=US CO Fort Collins Chicco AJ</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{Labeling</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|diseases=Obesity</ins></div></td></tr>
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|topics=Fatty acid</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|event=Oral</ins></div></td></tr>
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{MiP header page name}}</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and acknowledgements ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and acknowledgements ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::# Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::# Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:::: Corresponding author: adam.chicco@colostate.edu</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:::: Corresponding author: adam.chicco@colostate.edu</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{Labeling</del></div></td><td colspan="2"></td></tr>
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</table>
Tindle Lisa
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=237176&oldid=prev
Tindle Lisa at 10:14, 27 March 2023
2023-03-27T10:14:41Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:14, 27 March 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2023 Obergurgl AT</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2023 Obergurgl AT</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|abstract='''Authors:''' [[Chicco Adam J]], [[Le Catherine H]], [[Mulligan Christopher M]], [[Whitcomb Luke A]], [[Evans Amanda E]], [[Routh Melissa A]], [[Sparanga Genevieve C]] <br></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Cardiolipin (CL) is a tetra-acyl mitochondrial phospholipid that supports the optimal function of several mitochondrial membrane proteins and processes. In the healthy mammalian heart, the majority of CL species contain four linoleate acyl chains (L4CL). A marked depletion of cardiac L4CL is paralleled by an increase in CL species containing docosahexaenoic acid (DHA) in hyperphagic obese (''Lep<sup>ob</sup>''; OB) mice despite no change in dietary fat composition [1], but the mechanisms and functional relevance of these changes are unclear. We hypothesized that this shift in CL composition results from increased activity of delta-6 desaturase (D6D), the rate limiting enzyme in the biosynthesis of DHA and conversion of linoleate into highly unsaturated ω-6 fatty acids, by altering the distribution of fatty acids available for CL remodeling. To test this, we administered the selective D6D inhibitor SC-26196 (100 mg/kg/d in chow) to 4-5 month-old OB or lean (C57Bl/6) mice for 4 weeks. As hypothesized, D6D inhibition reversed obesity-related changes in cardiac CL composition, restoring L4CL and DHA-enriched CL species to within 5 % of levels in lean mice, which paralleled reciprocal shifts in the linoleate and DHA levels of total myocardial phospholipids. Obesity-related decreases in cardiac mitochondrial respiratory control by ADP (with NS pathway substrates) and greater mitochondrial H2O2 release during both LEAK and OXPHOS states were also abolished by D6D inhibition. These results corroborate accumulating evidence that cardiac CL composition is strongly influenced by the membrane fatty acids available for CL remodeling [2-3], and may impact the bioenergetic efficiency of mitochondrial respiration.<br></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"><small></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># Han X, Yang J, Yang K, ZhongdancZ, Abendschein DR, Gross RW (2007) Alterations in Myocardial Cardiolipin Content and Composition Occur at the Very Earliest Stages of Diabetes: A Shotgun Lipidomics Study Biochemistry https://doi.org/10.1021/bi7004015 </ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># Le CH et al. (2014) Delta-6-desaturase links PUFA metabolism with phospholipid remodeling and disease progression in heart failure. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000744 </ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. https://doi.org/10.1016/j.jlr.2021.100111 </ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></small></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|keywords=cardiolipin; polyunsatruated fatty acids; membrane composition; obesity; uncoupling</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=US CO Fort Collins Chicco AJ</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=US CO Fort Collins Chicco AJ</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Affiliations and acknowledgements ==</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::Chicco Adam J<sup>1-4</sup>, Le Catherine H<sup>2</sup>, Mulligan Christopher M<sup>3</sup>, Whitcomb Luke A<sup>1</sup>, Evans Amanda E<sup>1</sup>, Routh Melissa A<sup>2</sup>, Sparanga Genevieve C<sup>4</sup></ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::# Department of Biomedical Sciences, Colorado State University, Fort Collins, CO, USA</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::# Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO, USA</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::# Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, CO, USA</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::# Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, USA</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:::: Corresponding author: adam.chicco@colostate.edu</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td></tr>
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</table>
Tindle Lisa
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=236572&oldid=prev
Gnaiger Erich at 10:27, 15 March 2023
2023-03-15T10:27:40Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:27, 15 March 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=236495&oldid=prev
Tindle Lisa at 08:38, 13 March 2023
2023-03-13T08:38:36Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 08:38, 13 March 2023</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] <del style="font-weight: bold; text-decoration: none;">Chicco Adam J (2023) </del>Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MiP2023 Obergurgl AT]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[[MiP2023 Obergurgl AT]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Chicco Adam J</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Chicco Adam J</div></td></tr>
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Tindle Lisa
https://wiki.oroboros.at/index.php?title=Chicco_2023_MiP2023&diff=236494&oldid=prev
Tindle Lisa: Created page with "{{Abstract |title=Chicco Adam J Chicco Adam J (2023) Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitocho..."
2023-03-13T08:37:32Z
<p>Created page with "{{Abstract |title=<a href="/index.php/File:Chicco_Headshot.jpg" title="File:Chicco Headshot.jpg">left|100px|Chicco Adam J</a> Chicco Adam J (2023) Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitocho..."</p>
<p><b>New page</b></p><div>{{Abstract<br />
|title=[[File:Chicco Headshot.jpg|left|100px|Chicco Adam J]] Chicco Adam J (2023) Delta-6 desaturase inhibition reverses aberrant cardiolipin remodeling and mitochondrial dysfunction in the obese mouse heart.<br />
|info=[[MiP2023 Obergurgl AT]]<br />
|authors=Chicco Adam J<br />
|year=2023<br />
|event=MiP2023 Obergurgl AT<br />
|mipnetlab=US CO Fort Collins Chicco AJ<br />
}}<br />
{{Labeling<br />
|event=Oral<br />
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Tindle Lisa