Difference between revisions of "Citrate"
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{{MitoPedia | {{MitoPedia | ||
|description=[[File:Citrate 300 (1).png|left|100px|citrate]]'''citrate''', C<sub>6</sub>H<sub>5</sub>O<sub>7</sub><sup>-3</sup>, is a tricarboxylic acid trianion, intermediate of the TCA, obtained by deprotonation of the three carboxy groups of citric acid. Citrate is formed from [[oxaloacetate]] and acetyl-CoA through the catalytic activity of the [[citrate synthase]]. In the TCA, citrate forms isocitrate by the activity of the [[aconitase]]. Citrate can be transported out of the mitochondria by the tricarboxylate transport, situated in the inner mitochondrial membrane. The transport occurs as an antiport of malate from the cytosol and it is a key process for fatty acid and oxaloacetate synthesis in the cytosol. Communicated by [[Iglesias-Gonzalez Javier]] and [[Cecatto Cristiane]] last update 2020-10-05 | |||
|description=[[File:Citrate 300 (1).png|left|100px| | |||
'''citrate''', C<sub>6</sub>H<sub>5</sub>O<sub>7</sub><sup>-3</sup>, is a tricarboxylic acid trianion, intermediate of the TCA, obtained by deprotonation of the three carboxy groups of citric acid. Citrate is formed from [[oxaloacetate]] and acetyl-CoA through the catalytic activity of the [[citrate synthase]]. In the TCA, citrate forms isocitrate by the activity of the [[aconitase]]. Citrate can be transported out of the mitochondria by the tricarboxylate transport, situated in the inner mitochondrial membrane. The transport occurs as an antiport of malate from the cytosol and it is a key process for fatty acid and oxaloacetate synthesis in the cytosol. | |||
Communicated by [[Iglesias-Gonzalez Javier]] and [[Cecatto Cristiane]] last update 2020-10-05 | |||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
|type=Enzyme | |type=Enzyme | ||
|concepts_type=Enzyme | |||
|methods_type=Enzyme | |||
|O2k_and_high-resolution_respirometry_type=Enzyme | |||
|topics_type=Enzyme | |||
}} | }} | ||
{{MitoPedia concepts|type=Enzyme | {{MitoPedia concepts | ||
|type=Enzyme | |||
}} | }} | ||
{{MitoPedia methods|type=Enzyme | {{MitoPedia methods | ||
|type=Enzyme | |||
}} | }} | ||
{{MitoPedia O2k and high-resolution respirometry|type=Enzyme | {{MitoPedia O2k and high-resolution respirometry | ||
|type=Enzyme | |||
}} | }} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
Revision as of 08:44, 13 October 2020
- high-resolution terminology - matching measurements at high-resolution
Citrate
Description
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citrate, C6H5O7-3, is a tricarboxylic acid trianion, intermediate of the TCA, obtained by deprotonation of the three carboxy groups of citric acid. Citrate is formed from oxaloacetate and acetyl-CoA through the catalytic activity of the citrate synthase. In the TCA, citrate forms isocitrate by the activity of the aconitase. Citrate can be transported out of the mitochondria by the tricarboxylate transport, situated in the inner mitochondrial membrane. The transport occurs as an antiport of malate from the cytosol and it is a key process for fatty acid and oxaloacetate synthesis in the cytosol. Communicated by Iglesias-Gonzalez Javier and Cecatto Cristiane last update 2020-10-05
Reference: Gnaiger 2014 MitoPathways
MitoPedia topics: Substrate and metabolite
