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Difference between revisions of "Citrate"

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{{MitoPedia
{{MitoPedia
|description=[[File:Citrate 300 (1).png|left|100px|citrate]]'''citrate''', C<sub>6</sub>H<sub>5</sub>O<sub>7</sub><sup>-3</sup>, is a tricarboxylic acid trianion, intermediate of the TCA cycle, obtained by deprotonation of the three carboxy groups of citric acid. Citrate is formed from [[oxaloacetate]] and acetyl-CoA through the catalytic activity of the [[citrate synthase]]. In the TCA cycle, citrate forms isocitrate by the activity of the [[aconitase]]. Citrate can be transported out of the mitochondria by the tricarboxylate transport, situated in the inner mitochondrial membrane. The transport occurs as an antiport of malate from the cytosol and it is a key process for fatty acid and oxaloacetate synthesis in the cytosol.Β  <br>
|description=[[File:Citrate 300 (1).png|left|100px|citrate]]'''citrate''', C<sub>6</sub>H<sub>5</sub>O<sub>7</sub><sup>-3</sup>, is a tricarboxylic acid trianion, intermediate of the TCA cycle, obtained by deprotonation of the three carboxy groups of citric acid. Citrate is formed from [[oxaloacetate]] and acetyl-CoA through the catalytic activity of the [[citrate synthase]]. In the TCA cycle, citrate forms isocitrate by the activity of the [[aconitase]]. Citrate can be transported out of the mitochondria by the tricarboxylate transport, situated in the inner mitochondrial membrane. The transport occurs as an antiport of malate from the cytosol and it is a key process for fatty acid and oxaloacetate synthesis in the cytosol.Β  <br>
|info=[[Gnaiger 2014 MitoPathways]]
|info=[[Gnaiger 2020 BEC MitoPathways]]
|type=Enzyme
|concepts_type=Enzyme
|methods_type=Enzyme
|O2k_and_high-resolution_respirometry_type=Enzyme
|topics_type=Enzyme
}}
}}
Β  Communicated by [[Iglesias-Gonzalez Javier]] and [[Cecatto Cristiane]] last update 2020-10-05
Β  Communicated by [[Iglesias-Gonzalez Javier]] and [[Cecatto Cristiane]] last update 2020-10-05
{{MitoPedia concepts
|type=Enzyme
}}
{{MitoPedia methods
|type=Enzyme
}}
{{MitoPedia O2k and high-resolution respirometry
|type=Enzyme
}}
{{MitoPedia topics
{{MitoPedia topics
|mitopedia topic=Substrate and metabolite
|mitopedia topic=Substrate and metabolite
|type=Enzyme
}}
}}

Latest revision as of 18:55, 1 January 2021


high-resolution terminology - matching measurements at high-resolution


Citrate

Description

citrate

citrate, C6H5O7-3, is a tricarboxylic acid trianion, intermediate of the TCA cycle, obtained by deprotonation of the three carboxy groups of citric acid. Citrate is formed from oxaloacetate and acetyl-CoA through the catalytic activity of the citrate synthase. In the TCA cycle, citrate forms isocitrate by the activity of the aconitase. Citrate can be transported out of the mitochondria by the tricarboxylate transport, situated in the inner mitochondrial membrane. The transport occurs as an antiport of malate from the cytosol and it is a key process for fatty acid and oxaloacetate synthesis in the cytosol.


Reference: Gnaiger 2020 BEC MitoPathways

Communicated by Iglesias-Gonzalez Javier and Cecatto Cristiane last update 2020-10-05

MitoPedia topics: Substrate and metabolite