Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Difference between revisions of "Coupling-control efficiency"

From Bioblast
(12 intermediate revisions by 4 users not shown)
Line 1: Line 1:
{{MitoPedia
{{MitoPedia
|abbr=''CCC''
|abbr=''CCF''
|description='''Coupling control capacities''', ''CCC'', are [[flux control capacity|flux control capacities]], ''FCC'', at a constant [[ETS-competent substrate state]]. In mitochondrial preparations, there are three well-defined coupling states of respiration, ''L'', ''P'', ''E'' ([[LEAK]], [[OXPHOS]], [[ETS]]). In intact cells, state ''P'' cannot be induced, but a [[ROUTINE]] state of respiration, ''R'', can be measured.
|description='''Coupling control factors''', ''CCF'', are [[flux control factor]]s, ''FCF'', at a constant [[ET-pathway competent state]].
Β 
|info=[[Flux control factor]]
1. If the [[metabolic control variable]], ''X'', is an [[uncoupler]], the reference state ''Z'' is ''E''. Then two [[background state]]s, ''Y'', of coupling control are possible: The uncoupler may act on the ''L'' or ''P'' state in mt-preparations, and on the ''L'' or ''R'' state in intact cells. The corresponding coupling control capacities are:
}}
* [[E-L coupling control capacity|''E-L'' coupling control capacity]], Ξ”''j<sub>E-L</sub>'' = (''E-L'')/''E'' = 1-''L/E'' (mt-preparations and intact cells)
{{MitoPedia concepts
* [[E-P coupling control capacity|''E-P'' coupling control capacity]], Ξ”''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E'' (mt-preparations)
|mitopedia concept=Respiratory control ratio
* [[E-R coupling control capacity|''E-R'' coupling control capacity]], Ξ”''j<sub>E-P</sub>'' = (''E-R'')/''E'' = 1-''R/E'' (intact cells)
Β 
2. If the metablic control variable is stimulation by [[ADP]], D, or release of an inhibitor of phosphorylation of ADP to ATP ([[DT-phosphorylation]]; e.g. -Omy), the reference state ''Z'' is ''P'' in mt-preparations at saturating [[[ADP]]], or ''R'' in intact cells at physiologically controlled steady states of [ADP] and ATP-turnover. The background state ''Y'' is ''L'', and the corresponding coupling control capacities are:
* [[P-L coupling control capacity|''P-L'' coupling control capacity]], Ξ”''<sub>jP-L</sub>'' = (''P-L'')/''P'' = 1-''L/P'' (mt-preparations)
* [[R-L coupling control capacity|''R-L'' coupling control capacity]], Ξ”''j<sub>R-L</sub>'' = (''R-L'')/''R'' = 1-''L/R'' (intact cells)
Β 
|info=[[Gnaiger 2013 Abstract MiP2013]]
}}
}}
{{MitoPedia methods
{{MitoPedia methods
|mitopedia method=Respirometry
|mitopedia method=Respirometry
}}
}}
{{MitoPedia topics
{{MitoPedia O2k and high-resolution respirometry}}
|mitopedia topic=Respiratory control ratio
{{MitoPedia topics}}
}}
== Compare ==
* [[Coupling-control ratio]]
[[Category:Coupling control]]

Revision as of 15:17, 3 June 2020


high-resolution terminology - matching measurements at high-resolution


Coupling-control efficiency

Description

Coupling control factors, CCF, are flux control factors, FCF, at a constant ET-pathway competent state.

Abbreviation: CCF

Reference: Flux control factor


MitoPedia concepts: Respiratory control ratio 


MitoPedia methods: Respirometry 




Compare