Difference between revisions of "Djeungoue-Petga 2019 Cell Death Dis"
(Created page with "{{Publication |title=Djeungoue-Petga MA, Lurette O, Jean S, Hamel-CĂŽtĂ© G, MartĂn-JimĂ©nez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinas...")  |
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|title=Djeungoue-Petga MA, Lurette O, Jean S, Hamel-CĂŽtĂ© G, MartĂn-JimĂ©nez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940. | |title=Djeungoue-Petga MA, Lurette O, Jean S, Hamel-CĂŽtĂ© G, MartĂn-JimĂ©nez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/31819039 PMID: 31819039 Open Access] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/31819039 PMID: 31819039 Open Access] | ||
|authors=Djeungoue-Petga MA, Lurette O, Jean S, Hamel- | |authors=Djeungoue-Petga MA, Lurette O, Jean S, Hamel-Cote G, MartĂn-Jimenez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E | ||
|year=2019 | |year=2019 | ||
|journal=Cell Death Dis | |journal=Cell Death Dis | ||
Revision as of 10:08, 27 January 2020
| Djeungoue-Petga MA, Lurette O, Jean S, Hamel-CĂŽtĂ© G, MartĂn-JimĂ©nez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940. |
Djeungoue-Petga MA, Lurette O, Jean S, Hamel-Cote G, MartĂn-Jimenez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Cell Death Dis
Abstract: High levels and activity of Src kinase are common among breast cancer subtypes, and several inhibitors of the kinase are currently tested in clinical trials. Alterations in mitochondrial activity is also observed among the different types of breast cancer. Src kinase is localized in several subcellular compartments, including mitochondria where it targets several proteins to modulate the activity of the organelle. Although the subcellular localization of other oncogenes modulates the potency of known treatments, nothing is known about the specific role of intra-mitochondrial Src (mtSrc) in breast cancer. The aim of this work was to determine whether mtSrc kinase has specific impact on breast cancer cells. We first observed that activity of mtSrc is higher in breast cancer cells of the triple negative subtype. Over-expression of Src specifically targeted to mitochondria reduced mtDNA levels, mitochondrial membrane potential and cellular respiration. These alterations of mitochondrial functions led to lower cellular viability, shorter cell cycle and increased invasive capacity. Proteomic analyses revealed that mtSrc targets the mitochondrial single-stranded DNA-binding protein, a regulator of mtDNA replication. Our findings suggest that mtSrc promotes aggressiveness of breast cancer cells via phosphorylation of mitochondrial single-stranded DNA-binding protein leading to reduced mtDNA levels and mitochondrial activity. This study highlights the importance of considering the subcellular localization of Src kinase in the development of potent therapy for breast cancer.
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