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Donnelly 2022 Abstract Bioblast

From Bioblast
MitoEAGLE Hypoxia Task Group (2022) The ABC of hypoxia – what is the norm? Bioblast 2022: BEC Inaugural Conference.

Link: Bioblast 2022: BEC Inaugural Conference

Donnelly Chris, Schmitt Sabine, Cecatto Cristiane, Cardoso Luiza, Komlodi Timea, Place Nicolas, Kayser Bengt, Gnaiger Erich (2022)

Event: Bioblast 2022

Donnelly Chris

Hypoxia is a condition of oxygen levels below normoxia and opposite to hyperoxia. The normoxic reference state is defined by a set of simplifying arguments which unify the ABC concepts of hypoxia: (A) ambient normoxia at sea level in the contemporary atmosphere and at air saturation of aqueous environments, (B) biological compartmental O2 levels at ambient normoxia under physiological performance of healthy organisms in the absence of environmental stress (e.g. extreme temperatures; diving; a stranded whale), and (C) O2 levels above the control region, i.e., where the capacity for oxygen consumption is not compromised as evaluated by the kinetics of oxygen consumption. Conversely, the abc of hypoxia is concerned with deviations from these reference points caused by different mechanisms: (a) ambient alterations of oxygen levels, (b) biological O2 demand exceeding oxygen supply under pathological or experimental limitations of convective O2 transport or O2 diffusion, and (c) critical oxygen pressure and oxygen kinetics shifted by pathological and toxicological effects and environmental stress.

β€’ Keywords: anoxia; hyperoxia; hypoxia; normoxia; O2 concentration cO2

β€’ O2k-Network Lab: AT Innsbruck Oroboros, CH Lausanne Place N, HU Budapest Tretter L


Affiliations and support

Donnelly C(1,2), Schmitt S(1), Cecatto C(1), Cardoso L(1), Komlodi T(1,3), Place N(2), Kayser B(2), Gnaiger E(1)
  1. Oroboros Instruments, Innsbruck, Austria - erich.gnaiger@oroboros.at (corresponding author)
  2. Institute of Sport Sciences, Univ. Lausanne, Switzerland - chris.donnelly@unil.ch (presenting author)
  3. Department of Medical Biochemistry, Semmelweis University, Budapest, HU

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Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style 

Stress:Oxidative stress;RONS, Hypoxia 



Regulation: Aerobic glycolysis, Flux control, Temperature  Coupling state: ROUTINE 

HRR: Oxygraph-2k 

Tissue normoxia