Difference between revisions of "Fatty acid oxidation pathway control state"
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::::» [[Talk:Fatty acid oxidation |O2k-Network discussion forum: fatty acids used in permeabilized fibre assays]] | |||
::::» [[Fatty acid oxidation]] | |||
== FAO(L) == | |||
:::: FAO<sub>''L''</sub> | |||
== FAO(P) == | |||
:::: FAO<sub>''P''</sub> | |||
== FAO(E) == | |||
:::: FAO<sub>''E''</sub> | |||
[[Image:O2k-Publications.jpg|left|116px|link=O2k-Publications: Topics|O2k-Publications in the MiPMap]] | |||
== O2k-Publications: FAO == | |||
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[[Image:O2k-Publications.png|left|115px|link=http://www.bioblast.at/index.php/O2k-Publications: Topics|O2k-Publications in the MiPMap]] | |||
== O2k-Publications: FAO - Abstracts == | |||
'''''Sort in ascending/descending order by a click on one of the small symbols in squares below'''''. | |||
{{#ask:[[Category:Abstracts]] [[Instrument and method::Oxygraph-2k]] [[Substrate states::FAO]] | |||
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Revision as of 19:35, 9 May 2016
- high-resolution terminology - matching measurements at high-resolution
Fatty acid oxidation pathway control state
Description
In the fatty acid oxidation or FAO-linked substrate state, one or several fatty acids are supplied to feed electrons into the F-junction through fatty acyl CoA dehydrogenase (reduced form FADH2), to electron transferring flavoprotein (CETF), and further through the Q-junction to Complex III (CIII). FAO not only depends on electron transfer through the F-junction (which is typically rate-limiting) but simultaneously generates NADH and thus depends on N-junction throughput. Hence FAO can be inhibited completely by inhibition of Complex I (CI). In addition and independent of this source of NADH, the type N substrate malate is required as a co-substrate for FAO in mt-preparations, since accumulation of AcetylCo inhibits FAO in the absence of malate. Malate is oxidized in a reaction catalyzed by malate dehydrogenase to oxaloacetate (yielding NADH), which then stimulates the entry of AcetylCo into the TCA cycle catalyzed by citrate synthase.
Abbreviation: FAO, F
Reference: Gnaiger 2014 MitoPathways
MitoPedia O2k and high-resolution respirometry: "SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
SUIT state"SUIT state" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
FAO(L)
- FAOL
FAO(P)
- FAOP
FAO(E)
- FAOE
O2k-Publications: FAO
Sort in ascending/descending order by a click on one of the small symbols in squares below. Default sorting: chronological. Empty fields appear first in ascending order.
O2k-Publications: FAO - Abstracts
Sort in ascending/descending order by a click on one of the small symbols in squares below.