Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Fatty acid oxidation pathway control state

From Bioblast


high-resolution terminology - matching measurements at high-resolution


Fatty acid oxidation pathway control state

Description

F-junction

In the fatty acid oxidation or FAO-linked substrate state, one or several fatty acids are supplied to feed electrons into the F-junction through fatty acyl CoA dehydrogenase (reduced form FADH2), to electron transferring flavoprotein (CETF), and further through the Q-junction to Complex III (CIII). FAO not only depends on electron transfer through the F-junction (which is typically rate-limiting) but simultaneously generates NADH and thus depends on N-junction throughput. Hence FAO can be inhibited completely by inhibition of Complex I (CI). In addition and independent of this source of NADH, the type N substrate malate is required as a co-substrate for FAO in mt-preparations, since accumulation of AcetylCo inhibits FAO in the absence of malate. Malate is oxidized in a reaction catalyzed by malate dehydrogenase to oxaloacetate (yielding NADH), which then stimulates the entry of AcetylCo into the TCA cycle catalyzed by citrate synthase.

Abbreviation: FAO, F

Reference: Gnaiger 2014 MitoPathways


MitoPedia concepts: Respiratory state, SUIT state 

Β» O2k-Network discussion forum: fatty acids used in permeabilized fibre assays
Β» F-junction
Β» Fatty acid oxidation

FAO(L)

FAOL: FAO in the LEAK state


FAO(P)

FAOP: FAO in the OXPHOS state


FAO(E)

FAOE: FAO in the ETS state


O2k-Publications in the MiPMap

O2k-Publications: FAO

Sort in ascending/descending order by a click on one of the small symbols in squares below.
Default sorting: chronological. Empty fields appear first in ascending order. 


O2k-Publications in the MiPMap

O2k-Publications: FAO - Abstracts

Sort in ascending/descending order by a click on one of the small symbols in squares below.