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Fischer 2021 Antioxidants - Revision history
2024-03-29T06:44:39Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Fischer_2021_Antioxidants&diff=228298&oldid=prev
Gnaiger Erich at 14:07, 4 June 2022
2022-06-04T14:07:57Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and ''Hfe<sup>-/-</sup>'' related hemochromatosis alter hepatic mitochondrial function. <del style="font-weight: bold; text-decoration: none;">Antioxidants 10:1818. [</del>https://doi.org/10.3390/antiox10111818 <del style="font-weight: bold; text-decoration: none;">doi.org/10.3390/antiox10111818]</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and ''Hfe<sup>-/-</sup>'' related hemochromatosis alter hepatic mitochondrial function. https://doi.org/10.3390/antiox10111818</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.mdpi.com/2076-3921/10/11/1818 MDPI Open Access]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|info=<ins style="font-weight: bold; text-decoration: none;">Antioxidants 10:1818. </ins>[https://www.mdpi.com/2076-3921/10/11/1818 MDPI Open Access]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Fischer Christine, Volani Chiara, Komlodi Timea, Seifert Markus, Demetz Egon, Valente de Souza Lara, Auer Kristina, Petzer Verena, von Raffay Laura, Moser Patrizia, Gnaiger Erich, Weiss Guenter</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Fischer Christine, Volani Chiara, Komlodi Timea, Seifert Markus, Demetz Egon, Valente de Souza Lara, Auer Kristina, Petzer Verena, von Raffay Laura, Moser Patrizia, Gnaiger Erich, Weiss Guenter</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Fischer_2021_Antioxidants&diff=225526&oldid=prev
Gnaiger Erich at 07:35, 21 March 2022
2022-03-21T07:35:46Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:35, 21 March 2022</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-5656-5030]] [[Fischer C]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3600-4735]] [[Volani C]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9876-1411]] [[Komlodi T]], [[Seifert M]], [[Demetz E]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-0370-2791]] [[Valente de Souza L]], [[Auer K]], [[Petzer V]], [[von Raffay L]], [[Moser P]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] [[Gnaiger E]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-0709-2158]] [[Weiss G]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-5656-5030]] [[Fischer C]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3600-4735]] [[Volani C]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9876-1411]] [[Komlodi T]], [[Seifert M]], [[Demetz E]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-0370-2791]] [[Valente de Souza L]], [[Auer K]], [[Petzer V]], [[von Raffay L]], [[Moser P]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] [[Gnaiger E]], [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-0709-2158]] [[Weiss G]]</div></td></tr>
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Article processing charge ==</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">::::* MDPI: '''€ 1623.08'''</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== MitoFit Preprints ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== MitoFit Preprints ==</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Fischer_2021_Antioxidants&diff=222784&oldid=prev
Gnaiger Erich at 09:10, 10 December 2021
2021-12-10T09:10:33Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:10, 10 December 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-5656-5030]] Fischer C, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3600-4735]] Volani C, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9876-1411]] Komlodi T, Seifert M, Demetz E, [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-0370-2791]] Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] Gnaiger E, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-0709-2158]] Weiss G</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-5656-5030]] <ins style="font-weight: bold; text-decoration: none;">[[</ins>Fischer C<ins style="font-weight: bold; text-decoration: none;">]]</ins>, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3600-4735]] <ins style="font-weight: bold; text-decoration: none;">[[</ins>Volani C<ins style="font-weight: bold; text-decoration: none;">]]</ins>, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9876-1411]] <ins style="font-weight: bold; text-decoration: none;">[[</ins>Komlodi T<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>Seifert M<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>Demetz E<ins style="font-weight: bold; text-decoration: none;">]]</ins>, [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-0370-2791]] <ins style="font-weight: bold; text-decoration: none;">[[</ins>Valente de Souza L<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>Auer K<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>Petzer V<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>von Raffay L<ins style="font-weight: bold; text-decoration: none;">]]</ins>, <ins style="font-weight: bold; text-decoration: none;">[[</ins>Moser P<ins style="font-weight: bold; text-decoration: none;">]]</ins>, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] <ins style="font-weight: bold; text-decoration: none;">[[</ins>Gnaiger E<ins style="font-weight: bold; text-decoration: none;">]]</ins>, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-0709-2158]] <ins style="font-weight: bold; text-decoration: none;">[[</ins>Weiss G<ins style="font-weight: bold; text-decoration: none;">]]</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== MitoFit Preprints ==</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:::: Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and ''Hfe<sup>-/-</sup>'' related hemochromatosis alter hepatic mitochondrial function. MitoFit Preprints 2021.9. [[doi:10.26124/mitofit:2021-0009]]</ins></div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Fischer_2021_Antioxidants&diff=222475&oldid=prev
Gnaiger Erich: Created page with "{{Publication |title=Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron..."
2021-11-27T14:04:30Z
<p>Created page with "{{Publication |title=Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and ''Hfe<sup>-/-</sup>'' related hemochromatosis alter hepatic mitochondrial function. Antioxidants 10:1818. [https://doi.org/10.3390/antiox10111818 doi.org/10.3390/antiox10111818]<br />
|info=[https://www.mdpi.com/2076-3921/10/11/1818 MDPI Open Access]<br />
|authors=Fischer Christine, Volani Chiara, Komlodi Timea, Seifert Markus, Demetz Egon, Valente de Souza Lara, Auer Kristina, Petzer Verena, von Raffay Laura, Moser Patrizia, Gnaiger Erich, Weiss Guenter<br />
|year=2021<br />
|journal=Antioxidants<br />
|abstract=<br />
[[File:Fischer_2021_MitoFit_Fe_liver - graphical abstract.png|right|500px|Graphical abstract]] Iron is an essential co-factor for many cellular metabolic processes, and mitochondria are main sites of utilization. Iron accumulation promotes production of reactive oxygen species (ROS) via the catalytic activity of iron species. Herein, we investigated the consequences of dietary and genetic iron overload on mitochondrial function. C57/BL6N wildtype and ''Hfe<sup>-/-</sup>'' mice, the latter a genetic hemochromatosis model, received either normal diet (ND) or high iron diet (HI) for two weeks. Liver mitochondrial respiration was measured using high-resolution respirometry along with analysis of expression of specific proteins and ROS production. HI promoted tissue iron accumulation and slightly affected mitochondrial function in wildtype mice. Hepatic mitochondrial function was impaired in ''Hfe<sup>-/-</sup>'' mice on ND and HI. Compared to wildtype mice, ''Hfe<sup>-/-</sup>'' mice on ND showed increased mitochondrial respiratory capacity. ''Hfe<sup>-/-</sup>'' mice on HI showed very high liver iron levels, decreased mitochondrial respiratory capacity and increased ROS production associated with reduced mitochondrial aconitase activity. Although ''Hfe<sup>-/-</sup>'' resulted in increased mitochondrial iron loading, the concentration of metabolically reactive cytoplasmic iron and mitochondrial density remained unchanged. Our data shows multiple effects of dietary and genetic iron loading on mitochondrial function and linked metabolic pathways, providing an explanation for fatigue in iron-overloaded hemochromatosis patients and suggests iron reduction therapy for improvement of mitochondrial function.<br />
<br><br><br />
<br />
|keywords=hemochromatosis; iron overload; reactive oxygen species, ROS; mitochondria, mt; mitochondrial respiration; liver; fatigue<br />
|editor=Gnaiger E<br />
|mipnetlab=AT Innsbruck Oroboros<br />
}}<br />
ORC'''ID''': [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-5656-5030]] Fischer C, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3600-4735]] Volani C, [[File:ORCID.png|20px|link=https://orcid.org/0000-0001-9876-1411]] Komlodi T, Seifert M, Demetz E, [[File:ORCID.png|20px|link=https://orcid.org/0000-0002-0370-2791]] Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-3647-5895]] Gnaiger E, [[File:ORCID.png|20px|link=https://orcid.org/0000-0003-0709-2158]] Weiss G<br />
<br />
{{Labeling<br />
|area=Respiration<br />
|organism=Mouse<br />
|tissues=Liver<br />
|preparations=<br />
|topics=<br />
|couplingstates=LEAK, OXPHOS, ET<br />
|pathways=ROX, N, S, Gp<br />
|instruments=Oxygraph-2k<br />
|additional=<br />
}}</div>
Gnaiger Erich