https://wiki.oroboros.at/index.php?title=Flensted-Jensen_2021_Free_Radic_Biol_Med&feed=atom&action=historyFlensted-Jensen 2021 Free Radic Biol Med - Revision history2024-03-28T21:58:50ZRevision history for this page on the wikiMediaWiki 1.36.1https://wiki.oroboros.at/index.php?title=Flensted-Jensen_2021_Free_Radic_Biol_Med&diff=219489&oldid=prevPlangger Mario at 08:05, 5 August 20212021-08-05T08:05:57Z<p></p>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Obesity has been associated with increased production of reactive oxygen species (ROS), which may be involved in the development of cardiovascular disease and type 2 diabetes (T2D). Endurance exercise lowers ROS production and increases antioxidant capacity in muscle cells, but it is currently unknown whether high intensity interval training (HIT) elicits the same effects. Twelve sedentary obese subjects at risk of developing T2D took part in a six-week intervention, performing three HIT sessions per week (five 1-min sets of high-intensity cycling (125% of VO<sub><del style="font-weight: bold; text-decoration: none;">2</del></sub><del style="font-weight: bold; text-decoration: none;">peak</del>), with 90 s recovery in between sets). Muscle biopsies were obtained for assessment of ROS production (H<sub>2</sub>O<sub>2</sub> emission), mitochondrial respiratory capacity, and antioxidant protein levels before and after the intervention. H<sub>2</sub>O<sub>2</sub> emission decreased 60.4% after the intervention (Succinate 3 mmol・l<sup>-1</sup>), concurrent with a 35.1% increase in protein levels of the antioxidant manganese superoxide dismutase (MnSOD) and a trend towards increased levels of the antioxidant catalase (p = 0.06, 72.9%). These findings were accompanied by a 19% increased mitochondrial respiratory capacity (CI + II), a 6.9% increased <del style="font-weight: bold; text-decoration: none;">VO2peak </del>and a 1.7% lower body fat percentage. These effects were achieved after just 15 min of high-intensity work and 40 min of total time spent per week. Overall, this suggests that a relatively small amount of HIT is sufficient to induce beneficial effects on ROS production and antioxidant status in muscle cells, which may lower oxidative stress and potentially protect against the development of cardiovascular disease.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Obesity has been associated with increased production of reactive oxygen species (ROS), which may be involved in the development of cardiovascular disease and type 2 diabetes (T2D). Endurance exercise lowers ROS production and increases antioxidant capacity in muscle cells, but it is currently unknown whether high intensity interval training (HIT) elicits the same effects. Twelve sedentary obese subjects at risk of developing T2D took part in a six-week intervention, performing three HIT sessions per week (five 1-min sets of high-intensity cycling (125% of VO<sub><ins style="font-weight: bold; text-decoration: none;">2peak</ins></sub>), with 90 s recovery in between sets). Muscle biopsies were obtained for assessment of ROS production (H<sub>2</sub>O<sub>2</sub> emission), mitochondrial respiratory capacity, and antioxidant protein levels before and after the intervention. H<sub>2</sub>O<sub>2</sub> emission decreased 60.4% after the intervention (Succinate 3 mmol・l<sup>-1</sup>), concurrent with a 35.1% increase in protein levels of the antioxidant manganese superoxide dismutase (MnSOD) and a trend towards increased levels of the antioxidant catalase (p = 0.06, 72.9%). These findings were accompanied by a 19% increased mitochondrial respiratory capacity (CI + II), a 6.9% increased <ins style="font-weight: bold; text-decoration: none;">VO<sub>2peak</sub> </ins>and a 1.7% lower body fat percentage. These effects were achieved after just 15 min of high-intensity work and 40 min of total time spent per week. Overall, this suggests that a relatively small amount of HIT is sufficient to induce beneficial effects on ROS production and antioxidant status in muscle cells, which may lower oxidative stress and potentially protect against the development of cardiovascular disease.</div></td></tr>
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</table>Plangger Mariohttps://wiki.oroboros.at/index.php?title=Flensted-Jensen_2021_Free_Radic_Biol_Med&diff=219467&oldid=prevReiswig Regina at 12:07, 4 August 20212021-08-04T12:07:25Z<p></p>
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</table>Reiswig Reginahttps://wiki.oroboros.at/index.php?title=Flensted-Jensen_2021_Free_Radic_Biol_Med&diff=219466&oldid=prevReiswig Regina: Created page with "{{Publication |title=Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H<sub>2</sub>O<sub>2</sub> emission and in..."2021-08-04T12:06:26Z<p>Created page with "{{Publication |title=Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H<sub>2</sub>O<sub>2</sub> emission and in..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H<sub>2</sub>O<sub>2</sub> emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes. Free Radic Biol Med 173:1-6.<br />
|info=[https://pubmed.ncbi.nlm.nih.gov/34273538/ PMID: 34273538 Open Access]<br />
|authors=Flensted-Jensen Mathias, Gram Martin, Dela Flemming, Helge Joern Wulff, Larsen Steen<br />
|year=2021<br />
|journal=Free Radic Biol Med<br />
|abstract=Obesity has been associated with increased production of reactive oxygen species (ROS), which may be involved in the development of cardiovascular disease and type 2 diabetes (T2D). Endurance exercise lowers ROS production and increases antioxidant capacity in muscle cells, but it is currently unknown whether high intensity interval training (HIT) elicits the same effects. Twelve sedentary obese subjects at risk of developing T2D took part in a six-week intervention, performing three HIT sessions per week (five 1-min sets of high-intensity cycling (125% of VO<sub>2</sub>peak), with 90 s recovery in between sets). Muscle biopsies were obtained for assessment of ROS production (H<sub>2</sub>O<sub>2</sub> emission), mitochondrial respiratory capacity, and antioxidant protein levels before and after the intervention. H<sub>2</sub>O<sub>2</sub> emission decreased 60.4% after the intervention (Succinate 3 mmol・l<sup>-1</sup>), concurrent with a 35.1% increase in protein levels of the antioxidant manganese superoxide dismutase (MnSOD) and a trend towards increased levels of the antioxidant catalase (p = 0.06, 72.9%). These findings were accompanied by a 19% increased mitochondrial respiratory capacity (CI + II), a 6.9% increased VO2peak and a 1.7% lower body fat percentage. These effects were achieved after just 15 min of high-intensity work and 40 min of total time spent per week. Overall, this suggests that a relatively small amount of HIT is sufficient to induce beneficial effects on ROS production and antioxidant status in muscle cells, which may lower oxidative stress and potentially protect against the development of cardiovascular disease.<br />
|keywords=Antioxidants, HIT, Oxidative stress, Skeletal muscle<br />
|editor=[[Reiswig R]]<br />
}}<br />
{{Labeling<br />
|area=Respiration, Exercise physiology;nutrition;life style<br />
|diseases=Obesity<br />
|organism=Human<br />
|tissues=Skeletal muscle<br />
|preparations=Permeabilized tissue<br />
|couplingstates=LEAK, OXPHOS<br />
|pathways=N, NS<br />
|instruments=Oxygraph-2k<br />
|additional=2021-08<br />
}}</div>Reiswig Regina