Difference between revisions of "Flux control ratio"
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{{MitoPedia | {{MitoPedia | ||
|abbr=FCR | |abbr=''FCR'' | ||
|description='''Flux control ratios (FCR | |description='''Flux control ratios''' (''FCR''), are ratios of oxygen flux in different respiratory control states, normalized for maximum flux in a common reference state, to obtain theoretical lower and upper limits of 0.0 and 1.0 (0% and 100%). ''FCR'' obtained from a single respirometric incubation (sequential protocol; [[SUIT protocol]]) provide an internal normalization, expressing respiratory control independent of mitochondrial content and thus independent of a marker for mitochondrial amount. ''FCR'' obtained from separate (parallel) protocols depend on determination of a common [[mitochondrial marker]]. | ||
|info=[[MiPNet12.15]], Pesta_2010_Protocols | |info=[[MiPNet12.15]], [[Gnaiger_2009_IJBCB]], [[Pesta_2010_Protocols]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|discipline=Mitochondrial Physiology | |||
|topics=Respiration; OXPHOS; ETS Capacity, Flux Control; Additivity; Threshold; Excess Capacity | |topics=Respiration; OXPHOS; ETS Capacity, Flux Control; Additivity; Threshold; Excess Capacity | ||
}} | }} | ||
Revision as of 22:55, 18 September 2010
- high-resolution terminology - matching measurements at high-resolution
Flux control ratio
Description
Flux control ratios (FCR), are ratios of oxygen flux in different respiratory control states, normalized for maximum flux in a common reference state, to obtain theoretical lower and upper limits of 0.0 and 1.0 (0% and 100%). FCR obtained from a single respirometric incubation (sequential protocol; SUIT protocol) provide an internal normalization, expressing respiratory control independent of mitochondrial content and thus independent of a marker for mitochondrial amount. FCR obtained from separate (parallel) protocols depend on determination of a common mitochondrial marker.
Abbreviation: FCR
Reference: MiPNet12.15, Gnaiger_2009_IJBCB, Pesta_2010_Protocols
Labels:
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Flux Control; Additivity; Threshold; Excess Capacity"Flux Control; Additivity; Threshold; Excess Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
