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Gnaiger 2013 Abstract Neurocon Kolkata - Revision history
2024-03-29T01:19:26Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Gnaiger_2013_Abstract_Neurocon_Kolkata&diff=223678&oldid=prev
Gnaiger Erich at 16:28, 10 January 2022
2022-01-10T16:28:26Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=AT Innsbruck <del style="font-weight: bold; text-decoration: none;">Gnaiger E,</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=AT Innsbruck <ins style="font-weight: bold; text-decoration: none;">Oroboros</ins></div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Gnaiger_2013_Abstract_Neurocon_Kolkata&diff=187034&oldid=prev
Gnaiger Erich at 01:58, 29 October 2019
2019-10-29T01:58:12Z
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Gnaiger_2013_Abstract_Neurocon_Kolkata&diff=126265&oldid=prev
Gnaiger Erich at 11:42, 14 November 2016
2016-11-14T11:42:08Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=Neurocon 2013</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=Neurocon 2013</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Persistence of being overweight decreases the quality of life and increases the risk of developing early signs of neurodegeneration. Obesity and overweight are an emerging epidemic indicated by high body mass indexes, BMI>30 and >25 <del style="font-weight: bold; text-decoration: none;">kg∙m2</del>. BMI is a lifestyle accumulator integrating the imbalance between daily deficits of physical exercise and unmatched caloric intake. In addition, regional distributions of BMI correlate with chronic exposure to persistent organic pollutants in the environment and food chains, and pharmacological accumulation in post-industrial societies. Whereas correlations between high BMI and reduced cognitive function are well established, the underlying mechanisms remain elusive. The present analysis provides a turning point for finding the mechanistic basis to explain how BMI is related to neurological and brain function. Three previously disparate lines of study substantiate the hypothesis that preservation of mental health with age is related to maintenance of mitochondrial competence expressed as the capacity of oxidative phosphorylation (OXPHOS). (i) OXPHOS capacity in vastus lateralis declines significantly with BMI increasing from normal to overweight in healthy young and middle-aged men and women. Diminished mitochondrial density in muscle fibres is the main cause for low OXPHOS capacity. (ii) OXPHOS capacity in skeletal muscle is a potential marker for mitochondrial function in other highly aerobic tissues such as heart and brain. (iii) Low OXPHOS capacity in all or specific areas of the brain is causally related to impaired cognitive function and neurodegenerative diseases. Taken together, declining OXPHOS capacity in skeletal muscle with increasing BMI is suggested to indicate systemic ‘mitochondrial fever’ in a pro-inflammatory state of oxidative stress and reduced mitochondrial biogenesis. This translates high BMI to the risk of neurodegenerative disease. The health benefits are emphasized of maintaining mitochondrial competence high particularly with progressive age, as achieved by a physically active and nutritionally balanced life style. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Persistence of being overweight decreases the quality of life and increases the risk of developing early signs of neurodegeneration. Obesity and overweight are an emerging epidemic indicated by high body mass indexes, BMI>30 and >25 <ins style="font-weight: bold; text-decoration: none;">kg/m<sup>2</sup></ins>. BMI is a lifestyle accumulator integrating the imbalance between daily deficits of physical exercise and unmatched caloric intake. In addition, regional distributions of BMI correlate with chronic exposure to persistent organic pollutants in the environment and food chains, and pharmacological accumulation in post-industrial societies. Whereas correlations between high BMI and reduced cognitive function are well established, the underlying mechanisms remain elusive. The present analysis provides a turning point for finding the mechanistic basis to explain how BMI is related to neurological and brain function. Three previously disparate lines of study substantiate the hypothesis that preservation of mental health with age is related to maintenance of mitochondrial competence expressed as the capacity of oxidative phosphorylation (OXPHOS). (i) OXPHOS capacity in vastus lateralis declines significantly with BMI increasing from normal to overweight in healthy young and middle-aged men and women. Diminished mitochondrial density in muscle fibres is the main cause for low OXPHOS capacity. (ii) OXPHOS capacity in skeletal muscle is a potential marker for mitochondrial function in other highly aerobic tissues such as heart and brain. (iii) Low OXPHOS capacity in all or specific areas of the brain is causally related to impaired cognitive function and neurodegenerative diseases. Taken together, declining OXPHOS capacity in skeletal muscle with increasing BMI is suggested to indicate systemic ‘mitochondrial fever’ in a pro-inflammatory state of oxidative stress and reduced mitochondrial biogenesis. This translates high BMI to the risk of neurodegenerative disease. The health benefits are emphasized of maintaining mitochondrial competence high particularly with progressive age, as achieved by a physically active and nutritionally balanced life style. </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Contribution to K-Regio ''[[MitoCom_O2k-Fluorometer|MitoCom Tyrol]]''.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Contribution to K-Regio ''[[MitoCom_O2k-Fluorometer|MitoCom Tyrol]]''.</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Gnaiger_2013_Abstract_Neurocon_Kolkata&diff=94802&oldid=prev
Kandolf Georg: moved Gnaiger (2013) Abstract Neurocon Kolkata to Gnaiger 2013 Abstract Neurocon Kolkata
2015-07-06T09:31:18Z
<p>moved <a href="/index.php/Gnaiger_(2013)_Abstract_Neurocon_Kolkata" class="mw-redirect" title="Gnaiger (2013) Abstract Neurocon Kolkata">Gnaiger (2013) Abstract Neurocon Kolkata</a> to <a href="/index.php/Gnaiger_2013_Abstract_Neurocon_Kolkata" title="Gnaiger 2013 Abstract Neurocon Kolkata">Gnaiger 2013 Abstract Neurocon Kolkata</a></p>
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<td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:31, 6 July 2015</td>
</tr><tr><td colspan="2" class="diff-notice" lang="en"><div class="mw-diff-empty">(No difference)</div>
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Kandolf Georg
https://wiki.oroboros.at/index.php?title=Gnaiger_2013_Abstract_Neurocon_Kolkata&diff=92973&oldid=prev
Went Nora at 06:56, 15 June 2015
2015-06-15T06:56:48Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Persistence of being overweight decreases the quality of life and increases the risk of developing early signs of neurodegeneration. Obesity and overweight are an emerging epidemic indicated by high body mass indexes, BMI>30 and >25 kg∙m2. BMI is a lifestyle accumulator integrating the imbalance between daily deficits of physical exercise and unmatched caloric intake. In addition, regional distributions of BMI correlate with chronic exposure to persistent organic pollutants in the environment and food chains, and pharmacological accumulation in post-industrial societies. Whereas correlations between high BMI and reduced cognitive function are well established, the underlying mechanisms remain elusive. The present analysis provides a turning point for finding the mechanistic basis to explain how BMI is related to neurological and brain function. Three previously disparate lines of study substantiate the hypothesis that preservation of mental health with age is related to maintenance of mitochondrial competence expressed as the capacity of oxidative phosphorylation (OXPHOS). (i) OXPHOS capacity in vastus lateralis declines significantly with BMI increasing from normal to overweight in healthy young and middle-aged men and women. Diminished mitochondrial density in muscle fibres is the main cause for low OXPHOS capacity. (ii) OXPHOS capacity in skeletal muscle is a potential marker for mitochondrial function in other highly aerobic tissues such as heart and brain. (iii) Low OXPHOS capacity in all or specific areas of the brain is causally related to impaired cognitive function and neurodegenerative diseases. Taken together, declining OXPHOS capacity in skeletal muscle with increasing BMI is suggested to indicate systemic ‘mitochondrial fever’ in a pro-inflammatory state of oxidative stress and reduced mitochondrial biogenesis. This translates high BMI to the risk of neurodegenerative disease. The health benefits are emphasized of maintaining mitochondrial competence high particularly with progressive age, as achieved by a physically active and nutritionally balanced life style. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Persistence of being overweight decreases the quality of life and increases the risk of developing early signs of neurodegeneration. Obesity and overweight are an emerging epidemic indicated by high body mass indexes, BMI>30 and >25 kg∙m2. BMI is a lifestyle accumulator integrating the imbalance between daily deficits of physical exercise and unmatched caloric intake. In addition, regional distributions of BMI correlate with chronic exposure to persistent organic pollutants in the environment and food chains, and pharmacological accumulation in post-industrial societies. Whereas correlations between high BMI and reduced cognitive function are well established, the underlying mechanisms remain elusive. The present analysis provides a turning point for finding the mechanistic basis to explain how BMI is related to neurological and brain function. Three previously disparate lines of study substantiate the hypothesis that preservation of mental health with age is related to maintenance of mitochondrial competence expressed as the capacity of oxidative phosphorylation (OXPHOS). (i) OXPHOS capacity in vastus lateralis declines significantly with BMI increasing from normal to overweight in healthy young and middle-aged men and women. Diminished mitochondrial density in muscle fibres is the main cause for low OXPHOS capacity. (ii) OXPHOS capacity in skeletal muscle is a potential marker for mitochondrial function in other highly aerobic tissues such as heart and brain. (iii) Low OXPHOS capacity in all or specific areas of the brain is causally related to impaired cognitive function and neurodegenerative diseases. Taken together, declining OXPHOS capacity in skeletal muscle with increasing BMI is suggested to indicate systemic ‘mitochondrial fever’ in a pro-inflammatory state of oxidative stress and reduced mitochondrial biogenesis. This translates high BMI to the risk of neurodegenerative disease. The health benefits are emphasized of maintaining mitochondrial competence high particularly with progressive age, as achieved by a physically active and nutritionally balanced life style. </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[MitoCom#Acknowledgment|</del>Contribution to K-Regio<del style="font-weight: bold; text-decoration: none;">]] </del>''[[<del style="font-weight: bold; text-decoration: none;">MitoCom_K</del>-<del style="font-weight: bold; text-decoration: none;">Regio</del>|MitoCom Tyrol]]''.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Contribution to K-Regio ''[[<ins style="font-weight: bold; text-decoration: none;">MitoCom_O2k</ins>-<ins style="font-weight: bold; text-decoration: none;">Fluorometer</ins>|MitoCom Tyrol]]''.</div></td></tr>
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Went Nora
https://wiki.oroboros.at/index.php?title=Gnaiger_2013_Abstract_Neurocon_Kolkata&diff=81831&oldid=prev
Bader Helga at 09:12, 23 February 2015
2015-02-23T09:12:44Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:12, 23 February 2015</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Kolkata, India. Symposium: Neurocon 2013. January 17-20. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Kolkata, India. Symposium: Neurocon 2013. January 17-20.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://sites.google.com/site/neuroconkolkata/ Neurocon]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://sites.google.com/site/neuroconkolkata/ Neurocon]</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[MitoCom#Acknowledgment|Contribution to K-Regio]] ''[[MitoCom_K-Regio|MitoCom Tyrol]]''.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[MitoCom#Acknowledgment|Contribution to K-Regio]] ''[[MitoCom_K-Regio|MitoCom Tyrol]]''.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=AT Innsbruck Gnaiger E, </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=AT Innsbruck Gnaiger E,</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Human</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|organism=Human</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|preparations=Permeabilized tissue</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|preparations=Permeabilized tissue</div></td></tr>
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Bader Helga
https://wiki.oroboros.at/index.php?title=Gnaiger_2013_Abstract_Neurocon_Kolkata&diff=45044&oldid=prev
Laner Verena at 05:16, 29 May 2013
2013-05-29T05:16:48Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 05:16, 29 May 2013</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|title=Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, <del style="font-weight: bold; text-decoration: none;">Santiago </del>Kolkata, India. Symposium: Neurocon 2013. January 17-20. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|title=Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Kolkata, India. Symposium: Neurocon 2013. January 17-20. </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://sites.google.com/site/neuroconkolkata/ Neurocon]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://sites.google.com/site/neuroconkolkata/ Neurocon]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Gnaiger E</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Gnaiger E</div></td></tr>
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Laner Verena
https://wiki.oroboros.at/index.php?title=Gnaiger_2013_Abstract_Neurocon_Kolkata&diff=44652&oldid=prev
Laner Verena: Created page with "{{Abstract |title=Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Santiago Kolkata, Indi..."
2013-05-10T08:47:26Z
<p>Created page with "{{Abstract |title=Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Santiago Kolkata, Indi..."</p>
<p><b>New page</b></p><div>{{Abstract<br />
|title=Gnaiger E (2013) Body mass index and the risk of neurodegeneration: from mitochondrial fitness to brain function. Abstract Neurocon 2013, Santiago Kolkata, India. Symposium: Neurocon 2013. January 17-20. <br />
|info=[https://sites.google.com/site/neuroconkolkata/ Neurocon]<br />
|authors=Gnaiger E<br />
|year=2013<br />
|event=Neurocon 2013<br />
|abstract=Persistence of being overweight decreases the quality of life and increases the risk of developing early signs of neurodegeneration. Obesity and overweight are an emerging epidemic indicated by high body mass indexes, BMI>30 and >25 kg∙m2. BMI is a lifestyle accumulator integrating the imbalance between daily deficits of physical exercise and unmatched caloric intake. In addition, regional distributions of BMI correlate with chronic exposure to persistent organic pollutants in the environment and food chains, and pharmacological accumulation in post-industrial societies. Whereas correlations between high BMI and reduced cognitive function are well established, the underlying mechanisms remain elusive. The present analysis provides a turning point for finding the mechanistic basis to explain how BMI is related to neurological and brain function. Three previously disparate lines of study substantiate the hypothesis that preservation of mental health with age is related to maintenance of mitochondrial competence expressed as the capacity of oxidative phosphorylation (OXPHOS). (i) OXPHOS capacity in vastus lateralis declines significantly with BMI increasing from normal to overweight in healthy young and middle-aged men and women. Diminished mitochondrial density in muscle fibres is the main cause for low OXPHOS capacity. (ii) OXPHOS capacity in skeletal muscle is a potential marker for mitochondrial function in other highly aerobic tissues such as heart and brain. (iii) Low OXPHOS capacity in all or specific areas of the brain is causally related to impaired cognitive function and neurodegenerative diseases. Taken together, declining OXPHOS capacity in skeletal muscle with increasing BMI is suggested to indicate systemic ‘mitochondrial fever’ in a pro-inflammatory state of oxidative stress and reduced mitochondrial biogenesis. This translates high BMI to the risk of neurodegenerative disease. The health benefits are emphasized of maintaining mitochondrial competence high particularly with progressive age, as achieved by a physically active and nutritionally balanced life style. <br />
<br />
[[MitoCom#Acknowledgment|Contribution to K-Regio]] ''[[MitoCom_K-Regio|MitoCom Tyrol]]''.<br />
|mipnetlab=AT Innsbruck Gnaiger E, <br />
}}<br />
{{Labeling<br />
|instruments=Oxygraph-2k<br />
|injuries=Mitochondrial Disease; Degenerative Disease and Defect<br />
|organism=Human<br />
|tissues=Skeletal muscle<br />
|preparations=Permeabilized tissue<br />
|couplingstates=OXPHOS<br />
}}</div>
Laner Verena