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Difference between revisions of "Gnaiger 2015 Scand J Med Sci Sports"

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|journal=Scand J Med Sci Sports
|journal=Scand J Med Sci Sports
|abstract=During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from ''V''<sub>O2max</sub> and maximum capacities of oxidative phosphorylation.
|abstract=During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from ''V''<sub>O2max</sub> and maximum capacities of oxidative phosphorylation.
|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck OROBOROS, CA Vancouver Boushel RC, NL Maastricht Schrauwen P,
|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck OROBOROS, CA Vancouver Boushel RC, NL Maastricht Schrauwen P, DK Copenhagen Christiansen M, ES CN Las Palmas Calbet JA
}}
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Revision as of 10:11, 7 December 2015

Publications in the MiPMap
Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34.

» PMID: 26589126 Open Access

Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JA, Christiansen M, Helge JW, Saltin B (2015) Scand J Med Sci Sports

Abstract: During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from VO2max and maximum capacities of oxidative phosphorylation.


O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck OROBOROS, CA Vancouver Boushel RC, NL Maastricht Schrauwen P, DK Copenhagen Christiansen M, ES CN Las Palmas Calbet JA


Labels: MiParea: Respiration, mt-Biogenesis;mt-density, mtDNA;mt-genetics, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style 

Stress:Temperature  Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue  Enzyme: Marker enzyme, TCA cycle and matrix dehydrogenases  Regulation: Coupling efficiency;uncoupling, Cyt c  Coupling state: LEAK, OXPHOS, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property. 

HRR: Oxygraph-2k 

MitoFitPublication 

Project of the Copenhagen Muscle Research Centre (CMRC), Rigshospitalet, Copenhagen, Denmark (Prof. Dr. Bengt Saltin). Logo of the CMRC Greenland 2004 Expedition, designed by Crownprince Frederik of Denmark.

Greenland expedition CMRC: science and adventure

» Greenland Expedition CMRC



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