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Gnaiger 2020 PaduaMuscleDays - Revision history
2024-03-29T00:14:33Z
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Gnaiger Erich at 21:27, 23 February 2020
2020-02-23T21:27:04Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:27, 23 February 2020</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Gnaiger E (2020) Body mass excess, muscle mass, obesity and mitochondrial fitness. PaduaMuscleDays.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Gnaiger E (2020) Body mass excess, muscle mass, obesity and mitochondrial fitness. PaduaMuscleDays.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|info=[[<del style="font-weight: bold; text-decoration: none;">2020Spring </del>PaduaMuscleDays Padova IT |<del style="font-weight: bold; text-decoration: none;">Padua </del>Muscle Days]]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|info=[[<ins style="font-weight: bold; text-decoration: none;">2020 </ins>PaduaMuscleDays Padova IT |<ins style="font-weight: bold; text-decoration: none;">Padova </ins>Muscle Days]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Gnaiger E</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|authors=Gnaiger E</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2020</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|year=2020</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|event=<del style="font-weight: bold; text-decoration: none;">2020Spring </del>PaduaMuscleDays Padova IT</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|event=<ins style="font-weight: bold; text-decoration: none;">2020 </ins>PaduaMuscleDays Padova IT</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Skeletal muscle is the driver of whole-body aerobic capacity measured by spiroergometry as V<sub><del style="font-weight: bold; text-decoration: none;">O2max</del>/M</sub> [mL O<sub>2</sub>∙min<sup>-1</sup>∙kg<sup>-1</sup>]. Obesity is defined as accumulation of excess fat tissue mass, M<sub>FE</sub>=M<sub>F</sub>-M<sub>F</sub>° [kg/x]. M<sub>F</sub>° is the fat mass [kg] per individual [x] in the healthy reference population at a given height and total body mass <del style="font-weight: bold; text-decoration: none;">M° </del>without overweight[1]. Body fat excess, BFE=M<sub>FE</sub>/<del style="font-weight: bold; text-decoration: none;">M°</del>, is directly related to total body mass excess, BME=M<sub>E</sub>/<del style="font-weight: bold; text-decoration: none;">M°</del>, where M<sub>E</sub>=M-<del style="font-weight: bold; text-decoration: none;">M°</del>. In model 1, BFE does not reduce V<sub><del style="font-weight: bold; text-decoration: none;">O2max</del></sub> [mL O<sub>2</sub>∙min<sup>-1</sup>∙x<sup>-1</sup>], but BFE lowers V<sub><del style="font-weight: bold; text-decoration: none;">O2max</del>/M</sub> by increasing M. Experimentally, however, <del style="font-weight: bold; text-decoration: none;">VO</del><sub><del style="font-weight: bold; text-decoration: none;">2max</del>/M</sub> declines with BME much steeper than predicted by model 1. The more pronounced loss of ergometric fitness is due to the decline of mitochondrial respiratory capacity per muscle mass, ''m''<sub>M</sub>[2,3] as a function of BME. Yet this model 2 predicts an even lower V<sub><del style="font-weight: bold; text-decoration: none;">O2max</del>/M</sub> at overweight. Finally, model 3 includes the well-known ‘weight-lifting’ effect of obesity on increasing muscle mass with low mitochondrial density, providing a quantitatively complete link between low mitochondrial and whole body aerobic fitness in obesity before onset of sarcopenia. The decline of muscular mitochondrial fitness in overweight states is a biomarker of the systemic ''mitObesity'' syndrome: Compromised mitochondrial fitness across metabolically active organs provides the mechanistic link between obesity and comorbidities such as diabetes, cardiovascular and neurodegenerative diseases and various types of cancer bound to redox imbalance, inflammation, oxidative stress and insulin resistance. Today mitObesity is the world-wide leading cause of deaths and early aging, which can be prevented by an active lifestyle and improvement of the quality of life by exercise and caloric balance.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Skeletal muscle is the driver of whole-body aerobic capacity measured by spiroergometry as <ins style="font-weight: bold; text-decoration: none;">''</ins>V<ins style="font-weight: bold; text-decoration: none;">''<sub>O</ins><sub><ins style="font-weight: bold; text-decoration: none;">2<</ins>/<ins style="font-weight: bold; text-decoration: none;">sub>max/''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins></sub> [mL O<sub>2</sub>∙min<sup>-1</sup>∙kg<sup>-1</sup>]. Obesity is defined as accumulation of excess fat tissue mass, <ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins><sub>FE</sub>=<ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins><sub>F</sub>-<ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins><sub>F</sub>° [kg/x]. <ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins><sub>F</sub>° is the fat mass [kg] per individual [x] in the <ins style="font-weight: bold; text-decoration: none;">[[</ins>healthy reference population<ins style="font-weight: bold; text-decoration: none;">]] </ins>at a given height and total body mass <ins style="font-weight: bold; text-decoration: none;">''M''° </ins>without overweight [1]. Body fat excess, BFE=<ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins><sub>FE</sub>/<ins style="font-weight: bold; text-decoration: none;">''M''°</ins>, is directly related to total body mass excess, BME=<ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins><sub>E</sub>/<ins style="font-weight: bold; text-decoration: none;">''M''°</ins>, where <ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins><sub>E</sub>=<ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins>-<ins style="font-weight: bold; text-decoration: none;">''M''°</ins>. In model 1, BFE does not reduce <ins style="font-weight: bold; text-decoration: none;">''</ins>V<ins style="font-weight: bold; text-decoration: none;">''</ins><sub><ins style="font-weight: bold; text-decoration: none;">O<sub>2</sub>max</ins></sub> [mL O<sub>2</sub>∙min<sup>-1</sup>∙x<sup>-1</sup>], but BFE lowers <ins style="font-weight: bold; text-decoration: none;">''</ins>V<ins style="font-weight: bold; text-decoration: none;">''<sub>O<sub>2</ins><<ins style="font-weight: bold; text-decoration: none;">/</ins>sub><ins style="font-weight: bold; text-decoration: none;">max</ins>/<ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins></sub> by increasing <ins style="font-weight: bold; text-decoration: none;">''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins>. Experimentally, however, <ins style="font-weight: bold; text-decoration: none;">''V''<sub>O</ins><sub><ins style="font-weight: bold; text-decoration: none;">2<</ins>/<ins style="font-weight: bold; text-decoration: none;">sub>max/''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins></sub> declines with BME much steeper than predicted by model 1. The more pronounced loss of ergometric fitness is due to the decline of mitochondrial respiratory capacity per muscle mass, ''m''<sub>M</sub> [2,3]<ins style="font-weight: bold; text-decoration: none;">, </ins>as a function of BME. Yet this model 2 predicts an even lower <ins style="font-weight: bold; text-decoration: none;">''</ins>V<ins style="font-weight: bold; text-decoration: none;">''<sub>O</ins><sub><ins style="font-weight: bold; text-decoration: none;">2<</ins>/<ins style="font-weight: bold; text-decoration: none;">sub>max/''</ins>M<ins style="font-weight: bold; text-decoration: none;">''</ins></sub> at overweight. Finally, model 3 includes the well-known ‘weight-lifting’ effect of obesity on increasing muscle mass with low mitochondrial density, providing a quantitatively complete link between low mitochondrial and whole body aerobic fitness in obesity before onset of sarcopenia. The decline of muscular mitochondrial fitness in overweight states is a biomarker of the systemic ''mitObesity'' syndrome: Compromised mitochondrial fitness across metabolically active organs provides the mechanistic link between obesity and comorbidities such as diabetes, cardiovascular and neurodegenerative diseases and various types of cancer bound to redox imbalance, inflammation, oxidative stress and insulin resistance. Today mitObesity is the world-wide leading cause of deaths and early aging, which can be prevented by an active lifestyle and improvement of the quality of life by exercise and caloric balance.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|keywords=mitochondrial respiratory capacity, BME, VO2max, mitObesity, comorbidities, early aging,</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|keywords=mitochondrial respiratory capacity, BME, VO2max, mitObesity, comorbidities, early aging,</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Plangger M]],</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Plangger M]],</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck MitoFit, AT Innsbruck Oroboros</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck MitoFit, AT Innsbruck Oroboros</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">{{Labeling}}</del></div></td><td colspan="2"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and support ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Affiliations and support ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Erich Gnaiger (1,2)</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Erich Gnaiger (1,2)</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#D Swarovski Research Lab, Dept Visceral, Transplant Thoracic Surgery, Med Univ Innsbruck</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::# D Swarovski Research Lab, Dept Visceral, Transplant Thoracic Surgery, Med Univ Innsbruck</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Oroboros Instruments, Innsbruck; Austria. - erich.gnaiger@oroboros.at</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::# Oroboros Instruments, Innsbruck; Austria. - erich.gnaiger@oroboros.at</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Supported by project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 859770. Contribution to COST Action CA15203 MitoEAGLE funded by the Horizon 2020 Framework Programme of the European Union.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>::::Supported by project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 859770. Contribution to COST Action CA15203 MitoEAGLE funded by the Horizon 2020 Framework Programme of the European Union.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E (2019) OXPHOS capacity in human muscle tissue and body mass excess – the MitoEAGLE mission towards an integrative database. Mitochondrial Physiology Conference, Belgrade. https://www.mitophysiology.org/index.php/Gnaiger_2019_MiP2019 (Version 6; 2020-01-12).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::# Gnaiger E (2019) OXPHOS capacity in human muscle tissue and body mass excess – the MitoEAGLE mission towards an integrative database. Mitochondrial Physiology Conference, Belgrade. https://www.mitophysiology.org/index.php/Gnaiger_2019_MiP2019 (Version 6; 2020-01-12).</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::# Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JA, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25(Suppl 4):126–34.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::# Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JA, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25(Suppl 4):126–34.</div></td></tr>
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Gnaiger_2020_PaduaMuscleDays&diff=193025&oldid=prev
Plangger Mario at 15:48, 17 February 2020
2020-02-17T15:48:15Z
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Gnaiger_2020_PaduaMuscleDays&diff=193024&oldid=prev
Plangger Mario at 15:43, 17 February 2020
2020-02-17T15:43:17Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== References ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E OXPHOS capacity in human muscle tissue and body mass excess – the MitoEAGLE mission towards an integrative database. <del style="font-weight: bold; text-decoration: none;">2019 </del>Mitochondrial Physiology Conference, Belgrade. https://www.mitophysiology.org/index.php/Gnaiger_2019_MiP2019 (Version 6; 2020-01-12).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E <ins style="font-weight: bold; text-decoration: none;">(2019) </ins>OXPHOS capacity in human muscle tissue and body mass excess – the MitoEAGLE mission towards an integrative database. Mitochondrial Physiology Conference, Belgrade. https://www.mitophysiology.org/index.php/Gnaiger_2019_MiP2019 (Version 6; 2020-01-12).</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E<del style="font-weight: bold; text-decoration: none;">. </del>Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol <del style="font-weight: bold; text-decoration: none;">2009;</del>41:1837-45.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E <ins style="font-weight: bold; text-decoration: none;">(2009) </ins>Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E, Boushel R, Søndergaard H, <del style="font-weight: bold; text-decoration: none;">et al. </del>Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports <del style="font-weight: bold; text-decoration: none;">2015;</del>25(Suppl 4):126–34.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::::#Gnaiger E, Boushel R, Søndergaard H, <ins style="font-weight: bold; text-decoration: none;">Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JA, Christiansen M, Helge JW, Saltin B (2015) </ins>Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25(Suppl 4):126–34.</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Gnaiger_2020_PaduaMuscleDays&diff=193023&oldid=prev
Plangger Mario: Created page with "{{Abstract |title=Gnaiger E (2020) Body mass excess, muscle mass, obesity and mitochondrial fitness. PaduaMuscleDays. |info=2020Spring PaduaMuscleDays Padova IT |Padua Muscl..."
2020-02-17T15:40:03Z
<p>Created page with "{{Abstract |title=Gnaiger E (2020) Body mass excess, muscle mass, obesity and mitochondrial fitness. PaduaMuscleDays. |info=2020Spring PaduaMuscleDays Padova IT |Padua Muscl..."</p>
<p><b>New page</b></p><div>{{Abstract<br />
|title=Gnaiger E (2020) Body mass excess, muscle mass, obesity and mitochondrial fitness. PaduaMuscleDays.<br />
|info=[[2020Spring PaduaMuscleDays Padova IT |Padua Muscle Days]]<br />
|authors=Gnaiger E<br />
|year=2020<br />
|event=2020Spring PaduaMuscleDays Padova IT<br />
|abstract=Skeletal muscle is the driver of whole-body aerobic capacity measured by spiroergometry as V<sub>O2max/M</sub> [mL O<sub>2</sub>∙min<sup>-1</sup>∙kg<sup>-1</sup>]. Obesity is defined as accumulation of excess fat tissue mass, M<sub>FE</sub>=M<sub>F</sub>-M<sub>F</sub>° [kg/x]. M<sub>F</sub>° is the fat mass [kg] per individual [x] in the healthy reference population at a given height and total body mass M° without overweight[1]. Body fat excess, BFE=M<sub>FE</sub>/M°, is directly related to total body mass excess, BME=M<sub>E</sub>/M°, where M<sub>E</sub>=M-M°. In model 1, BFE does not reduce V<sub>O2max</sub> [mL O<sub>2</sub>∙min<sup>-1</sup>∙x<sup>-1</sup>], but BFE lowers V<sub>O2max/M</sub> by increasing M. Experimentally, however, VO<sub>2max/M</sub> declines with BME much steeper than predicted by model 1. The more pronounced loss of ergometric fitness is due to the decline of mitochondrial respiratory capacity per muscle mass, ''m''<sub>M</sub>[2,3] as a function of BME. Yet this model 2 predicts an even lower V<sub>O2max/M</sub> at overweight. Finally, model 3 includes the well-known ‘weight-lifting’ effect of obesity on increasing muscle mass with low mitochondrial density, providing a quantitatively complete link between low mitochondrial and whole body aerobic fitness in obesity before onset of sarcopenia. The decline of muscular mitochondrial fitness in overweight states is a biomarker of the systemic ''mitObesity'' syndrome: Compromised mitochondrial fitness across metabolically active organs provides the mechanistic link between obesity and comorbidities such as diabetes, cardiovascular and neurodegenerative diseases and various types of cancer bound to redox imbalance, inflammation, oxidative stress and insulin resistance. Today mitObesity is the world-wide leading cause of deaths and early aging, which can be prevented by an active lifestyle and improvement of the quality of life by exercise and caloric balance.<br />
|keywords=mitochondrial respiratory capacity, BME, VO2max, mitObesity, comorbidities, early aging,<br />
|editor=[[Plangger M]],<br />
}}<br />
{{Labeling}}<br />
== Affiliations and support ==<br />
::::Erich Gnaiger (1,2)<br />
::::#D Swarovski Research Lab, Dept Visceral, Transplant Thoracic Surgery, Med Univ Innsbruck<br />
::::#Oroboros Instruments, Innsbruck; Austria. - erich.gnaiger@oroboros.at<br />
<br />
::::Supported by project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 859770. Contribution to COST Action CA15203 MitoEAGLE funded by the Horizon 2020 Framework Programme of the European Union.<br />
<br />
== References ==<br />
::::#Gnaiger E OXPHOS capacity in human muscle tissue and body mass excess – the MitoEAGLE mission towards an integrative database. 2019 Mitochondrial Physiology Conference, Belgrade. https://www.mitophysiology.org/index.php/Gnaiger_2019_MiP2019 (Version 6; 2020-01-12).<br />
::::#Gnaiger E. Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 2009;41:1837-45.<br />
::::#Gnaiger E, Boushel R, Søndergaard H, et al. Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 2015;25(Suppl 4):126–34.</div>
Plangger Mario