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Gross 2023 MiP2023 - Revision history
2024-03-29T09:10:37Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Gross_2023_MiP2023&diff=240271&oldid=prev
Timon Alba at 14:43, 12 July 2023
2023-07-12T14:43:46Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:43, 12 July 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:::: Corresponding author: atan.gross@weizmann.ac.il</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:::: Corresponding author: atan.gross@weizmann.ac.il</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|event=<del style="font-weight: bold; text-decoration: none;">E1</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|event=<ins style="font-weight: bold; text-decoration: none;">Oral</ins></div></td></tr>
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Timon Alba
https://wiki.oroboros.at/index.php?title=Gross_2023_MiP2023&diff=240270&oldid=prev
Timon Alba at 14:43, 12 July 2023
2023-07-12T14:43:31Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:43, 12 July 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:::: Corresponding author: atan.gross@weizmann.ac.il</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>:::: Corresponding author: atan.gross@weizmann.ac.il</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|event=<del style="font-weight: bold; text-decoration: none;">Oral</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|event=<ins style="font-weight: bold; text-decoration: none;">E1</ins></div></td></tr>
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Timon Alba
https://wiki.oroboros.at/index.php?title=Gross_2023_MiP2023&diff=238196&oldid=prev
Tindle Lisa at 08:34, 18 April 2023
2023-04-18T08:34:19Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 08:34, 18 April 2023</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
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<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{MiP header page name}}</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Atan Gross.png|left|100px|Gross Atan]] M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Atan Gross.png|left|100px|Gross Atan]] M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Mitochondria are highly dynamic organelles that play fundamental roles in pivotal cellular processes including energy production, metabolism, and apoptosis. We are interested in understanding how these different mitochondrial processes are coordinated to respond to cellular stress. Many of our studies are focused on a novel mitochondrial protein named mitochondrial carrier homolog 2 (MTCH2) that mediates the response of mitochondria to stress signals initiating at the plasma membrane or at the nucleus. In the TNF/Fas-death receptor pathway, MTCH2 acts as a receptor-like protein for BH3-only BID, important for cytochrome c release and for Fas-induced liver apoptosis in vivo. On the other hand, in the DNA damage pathway, MTCH2 acts as the down-stream effector of the ATM kinase/BID pathway in haematopoietic stem cells (HSCs), controlling HSC quiescence and survival via regulation of mitochondria metabolism. More recently, we revealed that MTCH2 also plays a role in regulating mitochondrial metabolism in skeletal muscle, protecting from diet-induced obesity, and a role in regulating mitochondrial fusion/elongation, which is important in driving the exit from naïve pluripotency in embryonic stem cells (ESCs). Thus, MTCH2 is an important regulator of mitochondria morphology and metabolism acting at the interface between homeostasis and apoptosis. Determining MTCH2’s exact mechanism of action may lead to deciphering the mechanism by which BID, and perhaps other BCL-2 family members, regulate apoptosis.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Mitochondria are highly dynamic organelles that play fundamental roles in pivotal cellular processes including energy production, metabolism, and apoptosis. We are interested in understanding how these different mitochondrial processes are coordinated to respond to cellular stress. Many of our studies are focused on a novel mitochondrial protein named mitochondrial carrier homolog 2 (MTCH2) that mediates the response of mitochondria to stress signals initiating at the plasma membrane or at the nucleus. In the TNF/Fas-death receptor pathway, MTCH2 acts as a receptor-like protein for BH3-only BID, important for cytochrome c release and for Fas-induced liver apoptosis in vivo. On the other hand, in the DNA damage pathway, MTCH2 acts as the down-stream effector of the ATM kinase/BID pathway in haematopoietic stem cells (HSCs), controlling HSC quiescence and survival via regulation of mitochondria metabolism. More recently, we revealed that MTCH2 also plays a role in regulating mitochondrial metabolism in skeletal muscle, protecting from diet-induced obesity, and a role in regulating mitochondrial fusion/elongation, which is important in driving the exit from naïve pluripotency in embryonic stem cells (ESCs). Thus, MTCH2 is an important regulator of mitochondria morphology and metabolism acting at the interface between homeostasis and apoptosis. Determining MTCH2’s exact mechanism of action may lead to deciphering the mechanism by which BID, and perhaps other BCL-2 family members, regulate apoptosis.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Affiliation ==</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:::: Gross Atan</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:::: Department of Immunology and Regenerative Biology, Weizmann Institute of Science, Rehovot 76100, Israel</ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">:::: Corresponding author: atan.gross@weizmann.ac.il</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Labeling</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=Oral</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=Oral</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
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Tindle Lisa
https://wiki.oroboros.at/index.php?title=Gross_2023_MiP2023&diff=238195&oldid=prev
Tindle Lisa at 08:32, 18 April 2023
2023-04-18T08:32:58Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 08:32, 18 April 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Atan Gross.png|left|100px|Gross Atan]] M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Atan Gross.png|left|100px|Gross Atan]] M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2023 Obergurgl AT</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|event=MiP2023 Obergurgl AT</div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">|abstract=Mitochondria are highly dynamic organelles that play fundamental roles in pivotal cellular processes including energy production, metabolism, and apoptosis. We are interested in understanding how these different mitochondrial processes are coordinated to respond to cellular stress. Many of our studies are focused on a novel mitochondrial protein named mitochondrial carrier homolog 2 (MTCH2) that mediates the response of mitochondria to stress signals initiating at the plasma membrane or at the nucleus. In the TNF/Fas-death receptor pathway, MTCH2 acts as a receptor-like protein for BH3-only BID, important for cytochrome c release and for Fas-induced liver apoptosis in vivo. On the other hand, in the DNA damage pathway, MTCH2 acts as the down-stream effector of the ATM kinase/BID pathway in haematopoietic stem cells (HSCs), controlling HSC quiescence and survival via regulation of mitochondria metabolism. More recently, we revealed that MTCH2 also plays a role in regulating mitochondrial metabolism in skeletal muscle, protecting from diet-induced obesity, and a role in regulating mitochondrial fusion/elongation, which is important in driving the exit from naïve pluripotency in embryonic stem cells (ESCs). Thus, MTCH2 is an important regulator of mitochondria morphology and metabolism acting at the interface between homeostasis and apoptosis. Determining MTCH2’s exact mechanism of action may lead to deciphering the mechanism by which BID, and perhaps other BCL-2 family members, regulate apoptosis.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>}}</div></td></tr>
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Tindle Lisa
https://wiki.oroboros.at/index.php?title=Gross_2023_MiP2023&diff=236636&oldid=prev
Tindle Lisa at 17:09, 15 March 2023
2023-03-15T17:09:03Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:09, 15 March 2023</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Abstract</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Atan Gross.png|left|100px|Gross Atan]] M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=[[File:Atan Gross.png|left|100px|Gross Atan]] M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane.</div></td></tr>
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Tindle Lisa
https://wiki.oroboros.at/index.php?title=Gross_2023_MiP2023&diff=236635&oldid=prev
Tindle Lisa: Created page with "{{Abstract |title=Gross Atan M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane. |info=MiP2023 Obergurgl AT |authors=Gross Atan |y..."
2023-03-15T17:08:49Z
<p>Created page with "{{Abstract |title=<a href="/index.php/File:Atan_Gross.png" title="File:Atan Gross.png">left|100px|Gross Atan</a> M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane. |info=<a href="/index.php/MiP2023_Obergurgl_AT" title="MiP2023 Obergurgl AT">MiP2023 Obergurgl AT</a> |authors=Gross Atan |y..."</p>
<p><b>New page</b></p><div>{{Abstract<br />
|title=[[File:Atan Gross.png|left|100px|Gross Atan]] M(a)TCH2-ing up metabolism and apoptosis at the MOMbrane.<br />
|info=[[MiP2023 Obergurgl AT]]<br />
|authors=Gross Atan<br />
|year=2023<br />
|event=MiP2023 Obergurgl AT<br />
}}<br />
{{Labeling<br />
|event=Oral<br />
}}</div>
Tindle Lisa