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Difference between revisions of "Jezek P"

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{{Person
{{Person
|lastname=Jezek
|firstname=Peter
|firstname=Peter
|lastname=Jezek, Prof.Dr.
|title=Prof.Dr.
|mailaddress=jezek@biomed.cas.cz
|mailaddress=jezek@biomed.cas.cz
|address=Institute of Physiology, Dept. No. 75
|address=Institute of Physiology, Dept. No. 75
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Videnska 1083
Videnska 1083


CZ-14220 Prague 4, Czech Republic
CZ-14220 Prague 4
 
Czech Republic
|info=IOC24
|info=IOC24
}}
}}

Revision as of 15:29, 7 February 2012

Name Jezek Peter, Prof.Dr.
Institution
Address Institute of Physiology, Dept. No. 75

Academy of Sciences of the Czech Rep.

Videnska 1083

CZ-14220 Prague 4

Czech Republic,

City
State/Province
Country
Email jezek@biomed.cas.cz
Weblink
O2k-Network Lab CZ Prague Jezek P

CV (Nov 2011)

Born: April 22, 1957; Current job position: Head, Dept. Membrane Transport Biophysics, No.75, Inst.Physiology.

Engaged in the European Union project BIOCEV, Vestec by Prague.

Education: 1981: Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic, graduated in biophysics (title "RNDr" in physics); 1981-1986: a postgraduate fellowship at the Department of Bioenergetics, Institute of Physiology, Acad. Sci., under supervision of Josef Houštek, M.D 1986: Ph.D.-degree in Physiology of animals - Ph.D. thesis: "Ion transport and thermogenesis in brown adipose tissue mitochondria". 2001: achieved D.Sc.-degree (doctor scienciarum) in Physiology of animals (Acad.Sciences and Charles University, Prague). DSc. Thesis: „Mitochondrial uncoupling proteins, anion carriers and ion channels.“

Postdoctoral research training: 1987 Germany - lab. of Prof. Klaus Ring, President Univ. Frankfurt/Main, FRG. 1988-1990: U.S.A., Advanced postdoctoral fellowships in the lab. of Prof. K.D. Garlid at the Dept. Pharmacology, Medical College of Ohio, Toledo, Ohio, U.S.A. 1992: CSIC, CIB, Institute of Biology, Madrid - 8 months. Research and academic positions:

Since 1991: Head of the Department, permanent position of researcher in the Institute of Physiology, Prague; February 1991 formed own Department of Membrane transport Biophysics in this Institute, building completely new laboratory for biofluorescence methods and molecular biology up to present. Recently, he is developing the 3D superresolution microscopy, such as 4Pi microscopy and BiplaneFPALM microscopy.

Dr. P.J. is member of four commissions organizing Ph.D. studies in Czech Republic, supervising many Ph.D. students, several have already graduated under his supervision in biochemistry and biophysics, respectively. Memberships in Editorial Boards: member of the editorial board of the Int.J. Biochem.& Cell Biology (London).

Past achievement: Dr. P. J.: h-index 29; till 2010: >3000 citations, published 91 major scientific papers (total impact factor 351.5, i.e. 13.5 per year since 1984, an average IF 3.86 per paper; among which 18 appeared in the Journal of Biological Chemistry (2 in FASEB J., 1 in Aging Cell, 15 in IJBCB, 6 in BBA, 16 in FEBS Lett., 6 in J. Bioenerg. Biomembr., 3 in Eur. J. Bioch., 2 in Am. J. Physiol., etc.). One Czech and PCT patent (EU applied) in photodynamic therapy of tumors.

Dr. PJ has received numerous foreign grants such as Fogarty Int. grant 1992-1995, & Prof.Garlid, OGI. Portland OR, USA; grant of Czech&US Science & Technology Program 1996-1998, Prof.Garlid, OGI Portland OR, USA; DFG grant 1996-1997, (& Dr. D. Siemen, Univ. Kiel), PRONEX - Brazilian Federal Grant for the Excellence centers – 1998-2002 PIs: Prof. Vercesi, Arruda UNICAMP; DFG grant 2000-2001, (& Dr. P. Pohl, Univ. Halle, SRN); Fogarty International grant 2002-2005,& Garlid, Portland State University, OR, USA. Dr. P.J. has been developing (&colleagues) for past 10 years numerous techniques of modern mol. biology and recently superresolution 3Dimensional fluorescence microscopy.

List of milestone papers (antichronologically): (C = citations without autocitations)

  • Mlodzianoski MJ, Schreiner JM, Callahan SP, Smolková K, Dlasková A, Šantorová J, Ježek P, Bewersdorf J (2011) Sample drift correction in 3D fluorescence photoactivation localization microscopy. Opt. Express. 19: 15009-15019. IF 3.749
  • Dlasková A, Špaček T, Šantorová J, Plecitá-Hlavatá L, Berková Z, Saudek F, Lessard M, Bewersdorf J, Ježek P (2010) 4Pi microscopy reveals an impaired three-dimensional mitochondrial network of pancreatic islet -cells in an experimental model of type-2 diabetes. Biochim. Biophys Acta, Bioenergetics 1797: 1327-1341. IF 3.688
  • Plecitá-Hlavatá L, Lessard M, Šantorová J, Bewersdorf J, Ježek P (2008) Mitochondrial oxidative phosphorylation and energetic status are reflected by morphology of mitochondrial network in INS-1E and HEP-G2 cells viewed by 4Pi microscopy. Biochim. Biophys. Acta 1777: 834–846. IF 4.678 C=17
  • Dlasková A, Hlavatá L, Ježek P (2008) Oxidative stress caused by blocking of mitochondrial Complex I H+ pumping as a link in aging/disease vicious cycle. Int. J. Biochem. Cell Biol. 40: 1792–1805. IF 4.804 C=10 Indication of excessive superoxide production in living cells
  • Garlid KD et al (1996) On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein J. Biol. Chem. 271: 2615-2620. IF 7.452 C=180
  • Jabůrek M, Vařecha M, Gimeno RE, Dembski M, Ježek P, Zhang M, Burn P, Tartaglia LA, Garlid KD (1999) Transport function and regulation of mitochondrial uncoupling proteins 2 and 3. J. Biol. Chem. 274: 26003-26007. IF 7.666 C=189 Proof of fatty acid cycling mechanism for UCP2
  • Ježek P et al (1994) Transport of anions and protons by the mitochondrial uncoupling protein and its regulation by nucleotides and fatty acids: A new look at old hypotheses. J. Biol. Chem. 269: 26184-26190. IF 7.666 C=73 Proof of fatty acid cycling mechanism
  • Ježek P et al (1990) Reconstitution of the beef heart and rat liver mitochondrial K+/H+ (Na+/H+) antiporter: Quantification of K+ transport with the novel fluorescent probe PBFI. J. Biol. Chem. 265: 10522-10526. IF 7.666 C=47 Intro of fluorescent cation indicator method for reconstitution assays
  • Ježek P, Garlid KD (1990) New substrates and competitive inhibitors of the Cl- translocating pathway of the uncoupling protein of brown adipose tissue mitochondria. J. Biol. Chem. 265: 19303-19311. IF 7.666 C=64 Novel transport substrates of uncoupling protein revealed
  • Ježek P et al (1990) Reconstitution of the uncoupling protein of brown adipose tissue mitochodria: Demonstration of GDP-sensitive halide anion uniport. J. Biol. Chem. 265: 19296-19302. IF 7.666 C=32 Introduction of fluorescent anion indicator method for reconstitution assays