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Difference between revisions of "Zouhar 2023 MiP2023"

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{{Abstract
{{Abstract
|title=[[File:Kopecky J.png|left|100px|Kopecky Jan]] Major site of non-shivering thermogenesis: brown fat or skeletal muscle?
|title=[[File:Kopecky J.png|left|100px|Kopecky Jan]] Major site of non-shivering thermogenesis: brown fat or skeletal muscle?
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|year=2023
|year=2023
|event=MiP2023 Obergurgl AT
|event=MiP2023 Obergurgl AT
|abstract=Heat production is essential for maintaining a constant body temperature, and is an important component of energy balance. Well-described mechanisms involved in heat generation include shivering of muscle and non-shivering thermogenesis (NST) in brown adipose tissue (BAT). Thermogenesis in BAT, which is dependent on the presence of the mitochondrial protein UCP1, is the focus of interest for its potential use in the treatment of obesity. Other mechanisms of NST and their significance are relatively poorly understood. We have shown [1] that obesity-resistant A/J mice acclimated to cold failed to increase adrenergically stimulated NST in BAT and activated NST in skeletal muscle instead. Heat generation in muscle involved increased calcium ion cycling in the endoplasmic reticulum associated with higher mitochondrial oxidative activity. The involvement of different thermogenic mechanisms could be related to the different susceptibility to obesity.Β  The resistance of A/J mice to obesity may result, at least in part, from their ability to activate NST in muscle. Such mechanism may provide a more promising way to treat obesity than potential therapies based on increasing thermogenesis in BAT, as the capacity of skeletal muscle of adult human to burn fat energy stores is several fold greater than in BAT. Thus, only a relatively small increase in thermogenesis in muscle could significantly reduce adipose tissue deposition. How to achieve such an increase is a challenge for further research.
<small>
#Β  Janovska P et al., 2023, Mol Metab. https://doi.org/10.1016/j.molmet.2023.101683
</small>
|keywords=Non-shivering thermogenesis, Calcium cycling, cold acclimation
|mipnetlab=CZ Prague Kopecky J
|mipnetlab=CZ Prague Kopecky J
}}
}}
{{Labeling
{{Labeling
|organism=Mouse
|tissues=Skeletal muscle, Fat
|topics=Temperature
|event=Oral
|event=Oral
}}
}}
{{MiP header page name}}

Revision as of 08:49, 13 April 2023

Kopecky Jan
Major site of non-shivering thermogenesis: brown fat or skeletal muscle?

Link: MiP2023 Obergurgl AT

Kopecky Jan (2023)

Event: MiP2023 Obergurgl AT

Heat production is essential for maintaining a constant body temperature, and is an important component of energy balance. Well-described mechanisms involved in heat generation include shivering of muscle and non-shivering thermogenesis (NST) in brown adipose tissue (BAT). Thermogenesis in BAT, which is dependent on the presence of the mitochondrial protein UCP1, is the focus of interest for its potential use in the treatment of obesity. Other mechanisms of NST and their significance are relatively poorly understood. We have shown [1] that obesity-resistant A/J mice acclimated to cold failed to increase adrenergically stimulated NST in BAT and activated NST in skeletal muscle instead. Heat generation in muscle involved increased calcium ion cycling in the endoplasmic reticulum associated with higher mitochondrial oxidative activity. The involvement of different thermogenic mechanisms could be related to the different susceptibility to obesity. The resistance of A/J mice to obesity may result, at least in part, from their ability to activate NST in muscle. Such mechanism may provide a more promising way to treat obesity than potential therapies based on increasing thermogenesis in BAT, as the capacity of skeletal muscle of adult human to burn fat energy stores is several fold greater than in BAT. Thus, only a relatively small increase in thermogenesis in muscle could significantly reduce adipose tissue deposition. How to achieve such an increase is a challenge for further research.

  1. Janovska P et al., 2023, Mol Metab. https://doi.org/10.1016/j.molmet.2023.101683

β€’ Keywords: Non-shivering thermogenesis, Calcium cycling, cold acclimation

β€’ O2k-Network Lab: CZ Prague Kopecky J


Labels:


Organism: Mouse  Tissue;cell: Skeletal muscle, Fat 


Regulation: Temperature 


Event: Oral 


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