Difference between revisions of "Krumschnabel 1994 Experientia"
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{{Publication | {{Publication | ||
|title=Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483- | |title=Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-5. | ||
|info=http://link.springer.com/article/10.1007%2FBF01920752 | |info=[http://link.springer.com/article/10.1007%2FBF01920752 Springer-link] | ||
|authors=Krumschnabel G, Wieser W | |authors=Krumschnabel G, Wieser W | ||
|year=1994 | |year=1994 | ||
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|abstract=In isolated goldfish hepatocytes underaerobic conditions the energy requirement for the sodium pump (calculated from Rb+ flux) is closely matched by the ouabain-sensitive fraction of oxygen consumption, whereas during in vitroanoxia (cyanide inhibition of the electron transport chain) the measured ATP demand of the sodium pump clearly exceeds ouabain-sensitive ATP production by anaerobic glycolysis. We conclude that when the energy status of cells is low, part or all of the ATP spared by the inhibition of a particular function may be used for fuelling other ATP-consuming functions. | |abstract=In isolated goldfish hepatocytes underaerobic conditions the energy requirement for the sodium pump (calculated from Rb+ flux) is closely matched by the ouabain-sensitive fraction of oxygen consumption, whereas during in vitroanoxia (cyanide inhibition of the electron transport chain) the measured ATP demand of the sodium pump clearly exceeds ouabain-sensitive ATP production by anaerobic glycolysis. We conclude that when the energy status of cells is low, part or all of the ATP spared by the inhibition of a particular function may be used for fuelling other ATP-consuming functions. | ||
|keywords=goldfish, hepatocyte, sodium pump, protein synthesis, membrane-metabolic coupling, lactate, ouabain | |keywords=goldfish, hepatocyte, sodium pump, protein synthesis, membrane-metabolic coupling, lactate, ouabain | ||
|mipnetlab=AT Innsbruck | |mipnetlab=AT Innsbruck Oroboros | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
| | |area=Respiration | ||
|injuries=Ischemia-reperfusion | |||
|organism=Fishes | |||
|tissues=Liver | |tissues=Liver | ||
|preparations=Intact cells | |preparations=Intact cells | ||
Latest revision as of 12:09, 23 January 2019
| Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-5. |
Krumschnabel G, Wieser W (1994) Experientia
Abstract: In isolated goldfish hepatocytes underaerobic conditions the energy requirement for the sodium pump (calculated from Rb+ flux) is closely matched by the ouabain-sensitive fraction of oxygen consumption, whereas during in vitroanoxia (cyanide inhibition of the electron transport chain) the measured ATP demand of the sodium pump clearly exceeds ouabain-sensitive ATP production by anaerobic glycolysis. We conclude that when the energy status of cells is low, part or all of the ATP spared by the inhibition of a particular function may be used for fuelling other ATP-consuming functions. • Keywords: goldfish, hepatocyte, sodium pump, protein synthesis, membrane-metabolic coupling, lactate, ouabain
• O2k-Network Lab: AT Innsbruck Oroboros
Labels: MiParea: Respiration
Stress:Ischemia-reperfusion Organism: Fishes Tissue;cell: Liver Preparation: Intact cells
Coupling state: ROUTINE
HRR: Oxygraph-2k
