Difference between revisions of "Krumschnabel 1994 Experientia"
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|title=Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-485. Β | |title=Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-485. | ||
|info=http://link.springer.com/article/10.1007%2FBF01920752 | |info=http://link.springer.com/article/10.1007%2FBF01920752 | ||
|authors=Krumschnabel G, Wieser W | |authors=Krumschnabel G, Wieser W | ||
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{{Labeling | {{Labeling | ||
|taxonomic group=Fishes | |taxonomic group=Fishes | ||
|tissues=Liver | |tissues=Liver | ||
|preparations=Intact | |preparations=Intact cells | ||
|couplingstates=ROUTINE | |couplingstates=ROUTINE | ||
|instruments=Oxygraph-2k | |||
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Revision as of 08:43, 8 August 2013
Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-485. |
Β» http://link.springer.com/article/10.1007%2FBF01920752
Krumschnabel G, Wieser W (1994) Experientia
Abstract: In isolated goldfish hepatocytes underaerobic conditions the energy requirement for the sodium pump (calculated from Rb+ flux) is closely matched by the ouabain-sensitive fraction of oxygen consumption, whereas during in vitroanoxia (cyanide inhibition of the electron transport chain) the measured ATP demand of the sodium pump clearly exceeds ouabain-sensitive ATP production by anaerobic glycolysis. We conclude that when the energy status of cells is low, part or all of the ATP spared by the inhibition of a particular function may be used for fuelling other ATP-consuming functions. β’ Keywords: goldfish, hepatocyte, sodium pump, protein synthesis, membrane-metabolic coupling, lactate, ouabain
β’ O2k-Network Lab: AT Innsbruck OROBOROS
Labels:
Tissue;cell: Liver Preparation: Intact cells
Coupling state: ROUTINE
HRR: Oxygraph-2k