Krumschnabel 1994 Experientia

Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-485.

» http://link.springer.com/article/10.1007%2FBF01920752

Krumschnabel G, Wieser W (1994) Experientia

Abstract: In isolated goldfish hepatocytes underaerobic conditions the energy requirement for the sodium pump (calculated from Rb+ flux) is closely matched by the ouabain-sensitive fraction of oxygen consumption, whereas during in vitroanoxia (cyanide inhibition of the electron transport chain) the measured ATP demand of the sodium pump clearly exceeds ouabain-sensitive ATP production by anaerobic glycolysis. We conclude that when the energy status of cells is low, part or all of the ATP spared by the inhibition of a particular function may be used for fuelling other ATP-consuming functions. • Keywords: goldfish, hepatocyte, sodium pump, protein synthesis, membrane-metabolic coupling, lactate, ouabain

• O2k-Network Lab: AT Innsbruck OROBOROS

Labels:

Tissue;cell: Liver  Preparation: Intact Cell; Cultured; Primary"Intact Cell; Cultured; Primary" is not in the list (Intact organism, Intact organ, Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria, SMP, Chloroplasts, Enzyme, Oxidase;biochemical oxidation, ...) of allowed values for the "Preparation" property. 

Coupling state: ROUTINE 

HRR: Oxygraph-2k