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Ledur 2020 Sci Rep - Revision history
2024-03-28T07:59:01Z
Revision history for this page on the wiki
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Komlodi Timea at 07:31, 12 November 2020
2020-11-12T07:31:07Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 07:31, 12 November 2020</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/31988337 PMID: 31988337 Open Access]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://www.ncbi.nlm.nih.gov/pubmed/31988337 PMID: 31988337 Open Access]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|authors=Ledur <del style="font-weight: bold; text-decoration: none;">PF</del>, Karmirian <del style="font-weight: bold; text-decoration: none;">K</del>, Pedrosa <del style="font-weight: bold; text-decoration: none;">CDSG</del>, Souza <del style="font-weight: bold; text-decoration: none;">LRQ</del>, Assis-de-Lemos <del style="font-weight: bold; text-decoration: none;">G</del>, Martins <del style="font-weight: bold; text-decoration: none;">TM</del>, Ferreira <del style="font-weight: bold; text-decoration: none;">JCCG</del>, de Azevedo Reis <del style="font-weight: bold; text-decoration: none;">GF</del>, Silva <del style="font-weight: bold; text-decoration: none;">ES</del>, Silva <del style="font-weight: bold; text-decoration: none;">D</del>, Salerno <del style="font-weight: bold; text-decoration: none;">JA</del>, Ornelas <del style="font-weight: bold; text-decoration: none;">IM</del>, Devalle <del style="font-weight: bold; text-decoration: none;">S</del>, Madeiro da Costa <del style="font-weight: bold; text-decoration: none;">RF</del>, Goto-Silva <del style="font-weight: bold; text-decoration: none;">L</del>, Higa <del style="font-weight: bold; text-decoration: none;">LM</del>, Melo <del style="font-weight: bold; text-decoration: none;">A</del>, Tanuri <del style="font-weight: bold; text-decoration: none;">A</del>, Chimelli <del style="font-weight: bold; text-decoration: none;">L</del>, Murata <del style="font-weight: bold; text-decoration: none;">MM</del>, Garcez <del style="font-weight: bold; text-decoration: none;">PP</del>, Filippi-Chiela <del style="font-weight: bold; text-decoration: none;">EC</del>, Galina <del style="font-weight: bold; text-decoration: none;">A</del>, Borges <del style="font-weight: bold; text-decoration: none;">HL</del>, Rehen <del style="font-weight: bold; text-decoration: none;">SK</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|authors=Ledur <ins style="font-weight: bold; text-decoration: none;">Pitia Flores</ins>, Karmirian <ins style="font-weight: bold; text-decoration: none;">Karina</ins>, Pedrosa <ins style="font-weight: bold; text-decoration: none;">Carolina de Silva Gouveia</ins>, Souza <ins style="font-weight: bold; text-decoration: none;">Leticia Rocha Quintino</ins>, Assis-de-Lemos <ins style="font-weight: bold; text-decoration: none;">Gabriela</ins>, Martins <ins style="font-weight: bold; text-decoration: none;">Thiago Martino</ins>, Ferreira <ins style="font-weight: bold; text-decoration: none;">Jessica </ins></div></td></tr>
<tr><td colspan="2"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">de Cassia Cavalheiro Gomes</ins>, de Azevedo Reis <ins style="font-weight: bold; text-decoration: none;">Gabriel Ferreira</ins>, Silva <ins style="font-weight: bold; text-decoration: none;">Eduardo Santos</ins>, Silva <ins style="font-weight: bold; text-decoration: none;">Débora</ins>, Salerno <ins style="font-weight: bold; text-decoration: none;">Jose Alexandre</ins>, Ornelas <ins style="font-weight: bold; text-decoration: none;">Isis Moraes</ins>, Devalle <ins style="font-weight: bold; text-decoration: none;">Sylvie</ins>, Madeiro da Costa <ins style="font-weight: bold; text-decoration: none;">Rodrigo Furtado</ins>, Goto-Silva <ins style="font-weight: bold; text-decoration: none;">Livia</ins>, Higa <ins style="font-weight: bold; text-decoration: none;">Luiza Mendonca</ins>, Melo <ins style="font-weight: bold; text-decoration: none;">Adriana</ins>, Tanuri <ins style="font-weight: bold; text-decoration: none;">Amilcar</ins>, Chimelli <ins style="font-weight: bold; text-decoration: none;">Leila</ins>, Murata <ins style="font-weight: bold; text-decoration: none;">Marcos Massao</ins>, Garcez <ins style="font-weight: bold; text-decoration: none;">Patricia Pestana</ins>, Filippi-Chiela <ins style="font-weight: bold; text-decoration: none;">Eduardo Cremonese</ins>, Galina <ins style="font-weight: bold; text-decoration: none;">Antonio</ins>, Borges <ins style="font-weight: bold; text-decoration: none;">Helena Lobo</ins>, Rehen <ins style="font-weight: bold; text-decoration: none;">Stevens Kastrup</ins></div></td></tr>
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Komlodi Timea
https://wiki.oroboros.at/index.php?title=Ledur_2020_Sci_Rep&diff=193713&oldid=prev
Gnaiger Erich at 12:55, 23 February 2020
2020-02-23T12:55:31Z
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Gnaiger Erich
https://wiki.oroboros.at/index.php?title=Ledur_2020_Sci_Rep&diff=191687&oldid=prev
Plangger Mario at 13:35, 3 February 2020
2020-02-03T13:35:55Z
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Ledur_2020_Sci_Rep&diff=191670&oldid=prev
Plangger Mario at 12:16, 3 February 2020
2020-02-03T12:16:43Z
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Ledur_2020_Sci_Rep&diff=191669&oldid=prev
Plangger Mario at 12:15, 3 February 2020
2020-02-03T12:15:35Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:15, 3 February 2020</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Zika virus (ZIKV) has been extensively studied since it was linked to congenital malformations, and recent research has revealed that astrocytes are targets of ZIKV. However, the consequences of ZIKV infection, especially to this cell type, remain largely unknown, particularly considering integrative studies aiming to understand the crosstalk among key cellular mechanisms and fates involved in the neurotoxicity of the virus. Here, the consequences of ZIKV infection in iPSC-derived astrocytes are presented. Our results show ROS imbalance, mitochondrial defects and DNA breakage, which have been previously linked to neurological disorders. We have also detected glial reactivity, also present in mice and in ''post-mortem'' brains from infected neonates from the Northeast of Brazil. Given the role of glia in the developing brain, these findings may help to explain the observed effects in congenital Zika syndrome related to neuronal loss and motor deficit.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|abstract=Zika virus (ZIKV) has been extensively studied since it was linked to congenital malformations, and recent research has revealed that astrocytes are targets of ZIKV. However, the consequences of ZIKV infection, especially to this cell type, remain largely unknown, particularly considering integrative studies aiming to understand the crosstalk among key cellular mechanisms and fates involved in the neurotoxicity of the virus. Here, the consequences of ZIKV infection in iPSC-derived astrocytes are presented. Our results show ROS imbalance, mitochondrial defects and DNA breakage, which have been previously linked to neurological disorders. We have also detected glial reactivity, also present in mice and in ''post-mortem'' brains from infected neonates from the Northeast of Brazil. Given the role of glia in the developing brain, these findings may help to explain the observed effects in congenital Zika syndrome related to neuronal loss and motor deficit.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Plangger M]],</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|editor=[[Plangger M]],</div></td></tr>
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Plangger Mario
https://wiki.oroboros.at/index.php?title=Ledur_2020_Sci_Rep&diff=191668&oldid=prev
Plangger Mario: Created page with "{{Publication |title=Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM..."
2020-02-03T11:55:34Z
<p>Created page with "{{Publication |title=Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.<br />
|info=[https://www.ncbi.nlm.nih.gov/pubmed/31988337 PMID: 31988337 Open Access]<br />
|authors=Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK<br />
|year=2020<br />
|journal=Sci Rep<br />
|abstract=Zika virus (ZIKV) has been extensively studied since it was linked to congenital malformations, and recent research has revealed that astrocytes are targets of ZIKV. However, the consequences of ZIKV infection, especially to this cell type, remain largely unknown, particularly considering integrative studies aiming to understand the crosstalk among key cellular mechanisms and fates involved in the neurotoxicity of the virus. Here, the consequences of ZIKV infection in iPSC-derived astrocytes are presented. Our results show ROS imbalance, mitochondrial defects and DNA breakage, which have been previously linked to neurological disorders. We have also detected glial reactivity, also present in mice and in ''post-mortem'' brains from infected neonates from the Northeast of Brazil. Given the role of glia in the developing brain, these findings may help to explain the observed effects in congenital Zika syndrome related to neuronal loss and motor deficit.<br />
|editor=[[Plangger M]],<br />
}}<br />
{{Labeling<br />
|area=Respiration<br />
|instruments=Oxygraph-2k<br />
|additional=Labels, 2020-01,<br />
}}</div>
Plangger Mario