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Difference between revisions of "MiPNet27.06 Prague BEC tutorial-Living Communications pmF"

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{{Publication
{{Publication
|title=[[File:BEC-logo.png|right|120px|link=Gnaiger 2020 BEC MitoPathways]]
|title=[[File:BEC-logo.png|right|120px|link=Gnaiger 2020 BEC MitoPathways]]
'''Prague CZ''', 2022 Sep 22. BEC tutorial-Living Communications: ''pmF'' — pre [[EMC2022 Prague CZ]].
'''Prague CZ''', 2022 Sep 22. BEC tutorial-Living Communications: ''pmF'' — pre [[EMC2022 Prague CZ |EMC2022 Prague]].
|authors=MiPsociety
|authors=MiPsociety
|year=2022-09-22
|year=2022-09-22

Revision as of 14:05, 9 September 2022


Bioenergetics Communications        
Gnaiger 2020 BEC MitoPathways
       
Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1.
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Publications in the MiPMap
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Prague CZ, 2022 Sep 22. BEC tutorial-Living Communications: pmF — pre EMC2022 Prague.


MiPsociety (2022-09-22) Mitochondr Physiol Network

Abstract: BEC tutorial-Living Communications. Mitochondrial membrane potential and Peter Mitchell’s protonmotive force: elements of the science of bioenergetics. Preceding the EMC 2022 49th European Muscle Conference, Prague, Czech Republic.

Gnaiger 2020 BEC MitoPathways

The mitochondrial membrane potential is an element of the science of bioenergetics, linked to the control of respiratory flux and related mitochondrial functions. A PubMed search on ‘mitochondrial membrane potential’ yields nearly 40 000 results and 3442 for 2021 (search 2022-07-04), with a linear increase during the past 20 years. Chapter 8 on ‘Protonmotive pressure and respiratory control’ of Mitochondrial Pathways (Gnaiger 2020) introduces a novel perspective on Peter Mitchell’s protonmotive force, which incorporates the mitochondrial membrane potential. If you find the reading is tough, you are not alone. Join this BEC tutorial-Living Communications for an introduction into the relevant concepts of physical chemistry, which differ from misleading chapters in bioenergetics textbooks on potential gradients, Gibbs energy, protonmotive flow and force, and finally protonmotive pressure. This will introduce students (and teachers) to a new understanding of mitochondrial membrane potential and the protonmotive force, connecting the ideal gas equation, osmotic pressure, the Boltzmann constant and gas constant with Fick’s and Einstein’s diffusion equation. If theory gets tough, join for a follow-up retreat.


O2k-Network Lab: AT_Innsbruck_Oroboros, CZ Prague Houstek J

Figure 1.1. Coupling in oxidative phosphorylation is mediated by the protonmotive force pmF.



Last update: 2022-09-09


MiPsociety
Dr. Zdenek Drahota received from his team in Prague an Oroboros cake at his 80th birthday

This MiPevent is dedicated to Dr. Zdenek Drahota — one of the greatest mitochondrial physiologists of the Czech Republic — at his 90th birthday:

In collaboration with the Mitochondrial Physiology Society - see MiP2017


Venue and local organizers

Laboratory of Bioenergetics
Institute of Physiology CAS
Videnska 1083
142 20 Prague 4
Czech Republic


Program

Thursday, Sep 22
Time Section Contents
10:00-11:30 Introduction Protonmotive force pmF = ΔmFH+
  1. Mitchell's theorems on four integrated coupling modules
  2. Is the protonmotive force — units [mV] or [kJ/mol] — a force?
  3. Is the "Gibbs energy" [kJ/mol] a force?
  4. Why did Peter Mitchell use the symbol Δp?
11:30-12:00 Coffee/tea Chat
12:00-13:00 Extension Four protonmotive theorems on protonmotive pressure ΔmΠH+
  1. Diffusion gradients
  2. Compartments: diffusion and osmotic pressure
  3. Hydrogen ions and counterions
  4. Matrix volume fraction and flux-pressure linearity
» Programme: BEC tutorial-Living Communications pmF

Lecturer and participants

Participants

Restricted number of participants: countmax = (29 + 1) x

Registration and general information

  • Informal, no registration fee - send Email to: instruments@oroboros.at
  • Limited number of participants
  • Provide your name and affiliation (if you wish for the website)
  • Provide a foto (if you wish for the website)

COVID-19

The event will be held in accordance with current COVID regulations. A primary concern must be the safety of our participants and staff, which is why we reserve the right to cancel the event if there are any concerns/restrictions.


Recommended reading

Hydrogen ion circuit and coupling in OXPHOS
Gnaiger 2020 BEC MitoPathways
  1. Mitchell P (1966) Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. https://doi.org/10.1016/j.bbabio.2011.09.018
  2. Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. https://doi.org/10.26124/bec:2020-0002 - Chapter 8
  3. Gnaiger E (2021) The elementary unit — canonical reviewer's comments on: Bureau International des Poids et Mesures (2019) The International System of Units (SI) 9th ed. https://doi.org/10.26124/mitofit:200004.v2
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