MitoKit-CII

                

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MitoKit-CII

Description	Cell permeable compound - MitoKit-CII, 2 vials; 1 vial of NV118 (25 mg) + 1 vial of NV161 (10 mg)
Product ID	60200-01
Type	O2k
Link	MitoKit-CII MitoPedia
Image

Compounds

The MitoKit-CII consists of the first generation of NeuroVive Pharmaceutical AB's cell permeable succinate and malonate prodrugs. It was developed to stimulate (succinate) or inhibit (malonate) the Complex II of the respiratory electron transfer system in intact cells, and will expand the toolbox for evaluating the role of mitochondria in disease.

Compounds of MitoKit-CII

The MitoKit-CII is composed of the following compounds:

• Cell permeable compound NV118/MitoKit-CII

Description: Succinate prodrug: C₁₀H₁₄O₈, Molecular weight 262,2g.mol^-1

Aliquots of 25 mg

• Cell permeable compound NV161/MitoKit-CII

Description: Malonate prodrug: C₉H₁₂O₈, Molecular weight 248,2g.mol^-1

Aliquots of 10 mg

• Reference:

Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial Complex I deficiency. Nat Commun 7:12317. »Bioblast link« - Original publication introducing Mito-CII.

Expiry date of MitoKit-CII compounds (according to NeuroVive)

Before preparation:

• 3 years in -80° C
• 1 year in -20° C

Prepared:

• In DMSO solution

• at room temperature: 24 hours
• at -20 °C: for weeks

CAS-Numbers:

• NV118/MitoKit-CII: 1592635-33-0
• NV161/MitoKit-CII: 1432752-62-9

Labels: MiParea: Instruments;methods 

HRR: O2k-Protocol 

O2k-chemicals and media