Description
Cell permeable prodrugs, composed of NV161/MitoKit-CII and NV118/MitoKit-CII, of the Complex II substrate succinate increase ATP-linked mitochondrial respiration in CI-deficient human blood cells, fibroblasts and heart fibres.
Abbreviation: MitoKit-CII
Reference: MitoKit-CII, Ehinger 2016 Nat Commun
MitoPedia topics:
Media for respirometry
Application in HRR
Preparation
- Both compounds are dissolved in DMSO and stored in aliquots at -20 Β°C.
- We recommend the following dilutions for reaching the desired concentration in the experiments: