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Electron input though Complexes CI plus CII simultaneously into the Q-junction corresponds to TCA cycle function in vivo, with convergent electron flow through the ETS. In mt-preparations, CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since metabolite depletion in the absence of succinate prevents a significant activity of CII.
References
- Gnaiger E (2009) Mitochondrial pathways through Complexes I+II: Convergent electron transport at the Q-junction and additive effect of substrate combinations. Mitochondr. Physiol. Network 12.12: 1-20.
- Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int. J. Biochem. Cell Biol. 41: 1837–1845.
- high-resolution terminology - matching measurements at high-resolution
NS e-input
