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O2k-Publications alert - 2022
Dec 2022
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Bionenerg Commun 2022.19
Vera-Vives et al describe the setup of a reproducible method for constructing photosynthesis-irradiance curves based on oxygen evolution.
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Bionenerg Commun 2022.17
Alencar et al critically review the main metabolic features of BSF and provide a hypothesis to explain the unusual metabolic network and its biological significance for this parasite form.
- Alencar MB, Ramos EV, Silber AM, Zíková A, Oliveira MF (2022) The extraordinary energy metabolism of the bloodstream Trypanosoma brucei forms: a critical review and hypothesis. Bioenerg Commun 2022.17. https://doi.org/10.26124/bec:2022-0017
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What is the interaction between acylcarnitines and mitochondrial physiology?
Find out in the review from FAT4BRAIN partners.
- Dambrova M, Cecatto C, Vilskersts R, Liepinsh E (2022) Mitochondrial metabolites acylcarnitines: therapeutic potential and drug targets. Bioenerg Commun 2022.15. https://doi.org/10.26124/bec:2022-0015
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Nov 2022
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Kinases are central regulators of mitochondria and cancer drugs inhibiting kinases can target mitochondrial functions.
Read how mitochondrial bioenergetics can be used to predict cancer drug off-target effects in the recently published review.
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"1 mg/L treatment [of microplastics] resulted in a decrease in hepatic mitochondrial respiration and the mitochondrial membrane potential (ΔΨ), both of which were related with suppression of the mitochondrial respiratory chain (CI, CII, CII and CIV)."
- Félix L, Carreira P, Peixoto F (2022) Effects of chronic exposure of naturally weathered microplastics on oxidative stress level, behaviour, and mitochondrial function of adult zebrafish (Danio rerio). »Bioblast link«
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Chlorophyll fluorescence: Easy to measure, but not always easy to interpret.
The PAM protocol proposed by Roach (2022) helps deconvolute the various components of non-photochemical quenching in Chlamydomonas reinhardtii.
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- Nov- 21 Mo - World COPD Day
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"Our results suggest increased proton and electron leak and a decreased ETS capacity in platelets in chronic smoke-exposed animals"
- Białas AJ, Siewiera K, Watała C, Rybicka A, Grobelski B, Kośmider L, Kurek J, Miłkowska-Dymanowska J, Piotrowski WJ, Górski P (2018) Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs – a pilot study. »Bioblast link«
- from the O2k-Network »PL Lodz Watala C«
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Again not a Warburg effect - OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation
Reproducibility is a decisive element in the progress of knowledge. The recent study by Zhang et al (2022) fully confirmed the pattern of OXPHOS remodeling described by Schöpf et al (2020) in prostate cancer.
- Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. »Bioblast link«
- Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial Complex II reactive oxygen species generation in human prostate cancer. »Bioblast link«
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- Nov- 14 Mo - World Diabetes Day
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Mistimed eating, e.g., during shift-work, disrupts mitochondrial function and could contribute to type-2 diabetes mellitus
- de Goede P, Wüst RCI, Schomakers BV, Denis S, Vaz FM, Pras-Raves ML, van Weeghel M, Yi CX, Kalsbeek A, Houtkooper RH (2022) Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle. »Bioblast link«
- from the O2k-Network »NL Amsterdam Wuest RC«
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"High-altitude of the mountain spa environment improved mitochondrial fitness as could be seen from improved CI-linked OXPHOS and ET capacity of platelet mitochondria of patients with post-COVID-19 syndrome"
- Gvozdjáková A, Sumbalová Z, Kucharská J, Rausová Z, Kovalčíková E, Takácsová T, Navas P, López-Lluch G, Mojto V, Palacka P (2022) Mountain spa rehabilitation improved health of patients with post-COVID-19 syndrome: pilot study. »Bioblast link«
- from the O2k-Network »SK Bratislava Sumbalova Z«
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MCT1 plays a role in diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction.
- Hadjihambi A, Konstantinou C, Klohs J, Monsorno K, Le Guennec A, Donnelly C, Cox J, Kusumbe A, Hosford PS, Soffientini U, Lecca S, Mameli M, Jalan R, Paolicelli RC, Pellerin L (2022) Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. »Bioblast link«
- from the O2k-Network »CH Lausanne Place N«
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Oct 2022
- Oct-31 Mo- Breast Cancer Awareness Month
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"Haplogroup D5 [risk factor of breast cancer] exhibited reduced mitochondrial OXPHOS function compared to that of the non-D5 haplogroups […] because of not only lower Complex I activity but also decreased Complex III activity"
- Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, Shen L, Chen G, Fang H, Lyu J (2017) Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation. »Bioblast link«
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- Oct-25 Tu- Breast Cancer Awareness Month
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"mtSrc-dependent reduction of mtDNA levels lead to OXPHOS deficiency and a more aggressive phenotype [of breast cancer]. Inhibitors specific for mtSrc could therefore restore mitochondrial activity in TNBC cells, and ultimately stop malignancy"
- Djeungoue-Petga MA, Lurette O, Jean S, Hamel-Côté G, Martín-Jiménez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. »Bioblast link«
- from the O2k-Network »CA Moncton Hebert-Chatelain E«
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- Oct-19 We - Breast Cancer Awareness Month
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"Moderate aerobic physical exercise reduces TNBC [Triple-negative breast cancer] tumoral growth with effect on tumor metabolism, characterized by a reduction in mitochondrial respiratory capacity"
- Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. »Bioblast link«
- from the O2k-Network »BR Ribeirao Preto Alberici LC«
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“Chronic nitrate supplementation alone may not be a sufficient stimulus to elicit increases in muscle tissue oxygenation or respiration in [heart failure reduced ejection fraction]”
- Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. »Bioblast link«
- from the O2k-Network »AU Melbourne Bishop DJ«
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"NS-linked OXPHOS and ET capacity [were] decreased after prolonged exposure to BAM15."
- Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. »Bioblast link«
- from the O2k-Network »US LA Baton Rouge Noland RC«, »US LA Baton Rouge Irving BA« and »US OH Cleveland Hoppel CL«
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- Oct-10 Mo - World Mental Health Day
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Positive effect of regular physical activity on mitochondrial respiration in burnout syndrome
- Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.»Bioblast link«
- from the O2k-Network »CH Basel Eckert A«
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“Mitochondrial Ca2+ handling shapes astrocytic function and is key toward brain homeostasis.”
- from the O2k-Network »BR Sao Paulo Kowaltowski AJ«
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“Exposure to fat feeding during pregnancy can provide metabolic advantages in the offspring, which may explain the results of [mice weaned to regular chow] demonstrating improved mitochondrial respiratory function and efficiency in the presence of fatty acid substrates since the heart relies heavily upon efficient fatty acid oxidation to meet its energy demands.”
- Chiñas Merlin A, Gonzalez K, Mockler S, Perez Y, Jia UA, Chicco AJ, Ullevig SL, Chung E (2022) Switching to a standard chow diet at weaning improves the effects of maternal and postnatal high-fat and high-sucrose diet on cardiometabolic health in adult male mouse offspring. »Bioblast link«
- from the O2k-Network »US CO Fort Collins Chicco AJ«
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- Oct-03 Mo - Breast Cancer Awareness Month
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Doxorubicin-transferrin conjugate alters mitochondrial bioenergetics in breast cancer cells
- Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. »Bioblast link«
- from the O2k-Network »PL Lodz Watala C«
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Sep 2022
- Sep-29 Th - World Heart Day
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Respiration compromised in brain and heart tissue homogenate after cardiac arrest and ischemia/reperfusion injury
- Liang L, Zhang G, Cheng C, Li H, Jin T, Su C, Xiao Y, Bradley J, Peberdy MA, Ornato JP, Mangino MJ, Tang W (2021) High-resolution respirometry for evaluation of mitochondrial function on brain and heart homogenates in a rat model of cardiac arrest and cardiopulmonary resuscitation. -»Bioblast link«
- from the O2k-Network »US VA Richmond Mangino MJ«
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“Calcium-induced [mtPTP] is suppressed by exogenous additions of ADP compared to ADP combined with a hexokinase 2-deoxyglucose system of recycling ATP to ADP.”
- Bellissimo CA, Sondergaard S, Hughes MC, Ramos SV, Larsen S, Perry CGR (2022) The influence of adenylate cycling on mitochondrial calcium-induced permeability transition pore in permeabilized skeletal muscle fibres. https://doi.org/10.26124/mitofit:2022-0026
- from the O2k-Network »CA Toronto Perry CG«, »DK Copenhagen Larsen S«
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Investigating the cause of late-onset SLC25A26-related mitochondrial disease
- Schober FA, Tang JX, Sergeant K, Moedas MF, Zierz CM, Moore D, Smith C, Lewis D, Guha N, Hopton S, Falkous G, Lam A, Pyle A, Poulton J, Gorman GS, Taylor RW, Freyer C, Wredenberg A (2022) Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease. »Bioblast link«
- from the O2k-Network »BE Leuven Vermeersch P«
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"By tracing the carbon flow of the nutrients glucose and glutamine in cells derived from patients with different genetically defined causes of primary mitochondrial diseases (PMD), we identified several key metabolic changes supporting the major importance of an NAD+/NADH imbalance in PMD."
- Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. »Bioblast link«
- from the O2k-Network »BE Leuven Vermeersch P«
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Bioenerg Commun 2022.4: A review on the current landscape of mitochondrial disease drug development
- Åsander Frostner E, Simón Serrano S, Chamkha I, Donnelly E, Elmér E, Hansson MJ (2022) Towards a treatment for mitochondrial disease: current compounds in clinical development. https://doi.org/10.26124/bec:2022-0004
- from the O2k-Network »SE Lund Elmer E«
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- Sep-15 Th - World Lymphoma Awareness Day
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OXPHOS as a potential therapeutic target in classical Hodgkin lymphoma
- Birkenmeier K, Droese S, Wittig I, Winkelmann R, Käfer V, Doering C, Hartmann S, Wenz T, Reichert AS, Brandt U, Hansmann ML (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46. »Bioblast link«
- from the O2k-Network »DE Frankfurt Droese S«, »DE Frankfurt Wittig I« and »NL Nijmegen Brandt U«
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- Sep-05 Mo - Prostate Cancer Awareness Month
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“Mitochondria of the malignant prostate cells have a higher affinity for succinate and this metabolite supports mitochondrial physiology through the induction of expression and activities of mitochondrial complexes”
- Bastos Sant'Anna Silva AC, Perez-Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. Cancers 13:1727.»Bioblast link«
- from the O2k-Network »AT Innsbruck Oroboros« and »FR Bordeaux Rossignol R«
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- Sep- 01 Th - Leukemia and Lymphoma Awareness Month
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Metformin-mediated reduction of mitochondrial activity contributes to decreased cell viability in myeloproliferative neoplasms cells
- Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F (2018) Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. Cell Death Dis 9:311. »Bioblast link«
- from the O2k-Network »BR Ribeirao Preto Alberici LC«
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Aug 2022
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Exploring photosynthesis and dark respiration in the microalgae Chlamydomonas reinhardtii
- Went N, Di Marcello M, Gnaiger E (2021) Oxygen dependence of photosynthesis and light-enhanced dark respiration studied by High-Resolution PhotoRespirometry. MitoFit Prep 2021.5. doi:10.26124/mitofit:2021-0005
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Jul 2022
- Jul-28 Th - World Hepatitis Day
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Cells expressing hepatitis B protein X showed increased ROUTINE, LEAK and ET capacity compared to control cells.
- Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26. »Bioblast link«
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Jun 2022
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Scientific journals apply yesterday's concepts in the various formats of references with bewildering abbreviations of journals, volumes, issues, page numbers. We can do today's job much better using the BEC https-format — in line with DORA.
- »References in BEC https-format — in MitoPedia: BEC
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May 2022
*May- 19 Th
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"Instrumental QC is a cornerstone for experimental reproducibility."
- Baglivo E, Cardoso LHD, Cecatto C, Gnaiger E (2022) Statistical analysis of instrumental reproducibility as internal quality control in high-resolution respirometry. MitoFit Preprints 2022.18. https://doi.org/10.26124/mitofit:2022-0018.v2
- from the O2k-Network »AT Innsbruck Oroboros«
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"More systematic profiling of mitochondrial bioenergetic states in the presence and absence of lead molecules or kinase drugs could become an asset for anticipating non-desired off-target drug features."
Torres-Quesada Omar, Strich Sophie, Stefan Eduard (2022) Kinase perturbations redirect mitochondrial function. MitoFit Prep 2022.11. https://doi.org/10.26124/mitofit:2022-0011
- from the O2k-Network »AT Innsbruck Oroboros«
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Apr 2022
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"Proline catabolism through ProDH generates sufficient CIII and CIV proton pumping, supporting ATP production by F1FO-ATPase even when CI is inhibited"
Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation leading to high electron flow through reduction of ubiquinone supports ATP production by F1FO-ATPase in mitochondria with inhibited Complex I. MitoFit Preprints 2022.1.v3. https://doi.org/10.26124/mitofit:2022-0001.v3
- from the O2k-Network »AT Innsbruck Oroboros« and »HU Budapest Chinopoulos C«
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"The physiological Human Plasma-Like Media alters proliferative behavior, mitochondrial bioenergetic states and kinase drug sensitivity of cancer cells when compared to classic cell culture media."
- Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Human Plasma-Like Media fine-tune mitochondrial function and alter drug sensitivity in cancer cell lines. MitoFit Preprints 2022.8. https://doi.org/10.26124/mitofit:2022-0008
- from the O2k-Network »AT Innsbruck Oroboros«
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- Apr- 11 Mo - World Parkinson´s Disease Day
- Apr- 04 Mo - April is Parkinson's Awareness Month
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"Early stage α-synuclein pathology does not influence mitochondrial respiration in the striatum and amygdala [of mice]"
- Burtscher J, Copin JC, Sandi C, Lashuel HA (2020) Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala. eNeuro 7:ENEURO.0110-20.2020. »Bioblast link«
- from the O2k-Network »CH Lausanne Place N« and »CH Lausanne Sandi C«
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Mar 2022
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"MDH2 is a metabolic switch rewiring [electron transfer system] and TCA fuelling"
- Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. Biochim Biophys Acta Bioenerg 1863:148532. »Bioblast link«
- from the O2k-Network »FR Bordeaux Mourier A«
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Feb 2022
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Alterations in molecular and cellular pathways contribute to skeletal muscle-related symptoms in Covid-19
- Soares MN, Eggelbusch M, Naddaf E, Gerrits KHL, van der Schaaf M, van den Borst B, Wiersinga WJ, van Vugt M, Weijs PJM, Murray AJ, Wüst RCI (2022) Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19. J Cachexia Sarcopenia Muscle. »Bioblast link«
- from the O2k-Network »NL Amsterdam Wuest RC« and »UK Cambridge Murray AJ«
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'The scientific literature is exploding in quantity even as it stands still in literary quality.' - Wells WA (2004) Me write pretty one day: how to write a good scientific paper. J Cell Biol 165:757-8. »Bioblast link«
Sequential editions provide an opportunity to improve quality while preventing explosions on quantity. - Gnaiger (2021) Editorial Bioenerg Commun
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Now accepting living communications for Bioblast 2022 - BEC Inaugural Issue
-»More details«
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Acute sarcoplasmic reticulum calcium leak increases mitochondrial respiration after simulated sprint interval training
- Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219. »Bioblast link«
- from the O2k-Network »CH Lausanne Place N« and »ES Barcelona Garcia-Roves PM«
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Jan 2022
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Oroboros Ecosystem Agenda and Bioblast alert consider to refrain from propagating scientific publications in paywall and predatory journals. A definition is required of paywall and predatory journals. Paywall and predatory journals are not the future of scientific communication.
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From preprint to journal publication:
- Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe-/- related hemochromatosis alter hepatic mitochondrial function. Antioxidants 10:1818. doi.org/10.3390/antiox10111818
- from the O2k-Network »AT Innsbruck Oroboros«
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'The burden of responsibilities for an urgent change of the academic publishing ecosystem and scientific communication culture must be shared between the shoulders of individual scientists, the backbone of scientific institutions, and the neurology of governmental regulations and funding agencies.' - Gnaiger (2021) Editorial Bioenerg Commun
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Elsevier bought Pergamon Press in 1991 for £440m (£919m today) from Robert Maxwell. R Maxwell may be known in relation to financial scandals and to his daughter Ghislaine Maxwell who was convicted on 2021-12-29 linked to several federal crimes including her involvement in a sex-trafficking ring with Jeffrey Epstein, to who's former friends belonged British Prince Andrew, former Prime Minister Tony Blair, or ex-US-presidents Bill Clinton and Donald Trump. Due to paywall journals, Open Access in science remains an unfulfilled dream. - Gnaiger (2021) Editorial BEC Living Communication (2022-01-04)
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The process of Lewy body formation in Parkinson's Disease induces mitochondrial deficits
- Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA (2020) The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci U S A 117:4971-82. Mahul-Mellier 2020 Proc Natl Acad Sci U S A
- from the O2k-Network »CH Lausanne Place N«
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'Assuming a publication charge of € 1200 per article, scientists mentioning mitochondria or photosynthesis pay € 100 000 every day in 2021 for ‘selling’ their output to publishers ― over € 36 Mill per year. ' - Gnaiger (2021) Editorial Bioenerg Commun
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Stay alert
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