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Oroboros Instruments

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» NextGen-O2k «
Supported by the project NextGen-O2k, which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 859770
About Oroboros Advance bioenergetics to mitochondrial and cell physiology with the award-winning Oroboros O2k

Power-O2k Long-term experience in high-resolution respirometry, HRR: >1,100 O2k sold

O2k-Workshops Meet the experts at the outstanding O2k-Workshops on HRR

O2k-Publications in the MiPMap Browse through 3306 O2k-Publications

O2k-Network Join the world-wide O2k-Network

O2k-Catalogue The O2k-technology represents innovation, optimization, and continuous development

O2k-purchase Fair prices - low running costs

Oroboros support Quality instead of empty advertisements

Gentle Science Gentle Science - cooperation and corporate social responsibility

Quality management Quality management to tackle the reproducibility crisis with the O2k

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Oroboros News

MitoPedia New in MitoPedia: 100 years of IUPAC - towards a common language.

O2k-brief High-Resolution Respirometry. Respiration media - Wollenman 2017


DatLab 7.3 release

We are proud to release DatLab 7.3, optimized for the Oroboros O2k-Series H, and enhancing applications of all O2k configurations. The software includes numerous new features:

  • Calibration and flux analysis – simplified for O2k-FluoRespirometer channels and add-on O2k-Modules.
  • DatLab Protocols: Both (1) instrumental protocols for quality control and (2) experimental substrate-uncoupler-inhibitor (SUIT) protocols guide the user step-by-step through the experiment, with programmed Events (titrations) and Marks (sections of the experiment for statistical analysis).
  • Browse DL-Protocols and templates: In a library of standardized protocols, each SUIT protocol is explained by an application example and supported by a template for data analysis.
  • Lower O2 limit: Respiration becomes oxygen dependent below a critical oxygen concentration. An automatic warning alerts the user to avoid hypoxia.
  • Graphs: Standard graph layouts can be selected, adjusted, and saved as User-defined layouts, to view O2k-MultiSensor experiments and export graphs for publication. Titration-induced peaks and spikes can be deleted.
  • Mark statistics: New statistical features are available for numerical display of results from DL-Protocol Marks and user-defined marks: median, average, SD, outlier index. These data can be exported for further analysis.

» Recent O2k-Publications
Did you know: You can search for pathological states-such as cancer-, where 257 references are listed.

  • Bajzikova et al (2018) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab S1550-4131(18)30646-6 [Epub ahead of print]. - »Bioblast link«
  • Oemer et al (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63. - »Bioblast link«
  • Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70. - »Bioblast link«

The World as a Laboratory - science and adventure

  • Gnaiger et al (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34. - »Bioblast link«