Difference between revisions of "Oroboros Laboratory"

Latest revision as of 16:58, 15 February 2024

Oroboros Laboratory

Mitochondria and Cell Research - the Oroboros Ecosystem

Scientists with a gentle touch of entrepreneurship

Oroboros O2k-Laboratory

42 O2k-Chambers (21 O2k)

The Oroboros O2k-Laboratory ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project MitoCom Tyrol in June 2013. It comprises 140 sqm which are divided into the office and research areas.

Twenty-one O2k instruments for HRR (42 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.

Two additional O2ks (4 chambers) are devoted to instrumental development.

According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.

» More details: Oroboros Support

Joint projects

Functional Mitochondrial Diagnostics (VASCage)	Rebecka Hardorp Alejandra Romero-Martinez, Dr. Joshua Wieser-Insole
ALAS	Ana Pfleger, Mag. Thomas Roach, PhD
TissueModels	Markus Keller, Dr. Anna Smaling, MRes
MitoKIN	Eduard Stefan, PhD Sophie Strich Omar Torres-Quesada, PhD
CureMILS	Marta Suarez-Cubero

OXPHOS analysis

SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using

coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping (cell ergometry).

» Current projects

» Partners in the Oroboros Ecosystem

» Visiting scientists

Keywords

Bioblast links: Oroboros Laboratory - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

» Oroboros Laboratory

» Projects

» Oroboros Laboratory: visiting scientists

» O2k-Open Support by Oroboros experts

@@ Line 1: / Line 1: @@
 {{Template:OROBOROS header page name}}
 {{Template:OROBOROS Slogan}}
-:::: <big>'''Two labs - one team: Oroboros O2k-Laboratory and DSL-Oroboros Research Lab'''</big>
 :::: <big>'''Scientists with a gentle touch of entrepreneurship'''</big>
@@ Line 12: / Line 11: @@
 __TOC__
-=== Oroboros O2k-Laboratory ===
+== Oroboros O2k-Laboratory ==
-:::: '''48 O2k-Chambers (24 O2k)'''
+:::: '''42 O2k-Chambers (21 O2k)'''
 :::: The '''Oroboros O2k-Laboratory''' ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project [[MitoCom_O2k-Fluorometer| MitoCom Tyrol]] in June 2013. It comprises 140 sqm which are divided into the office and research areas.
-::::* Twenty four O2k instruments for HRR (48 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.
+::::* Twenty-one O2k instruments for HRR (42 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.
 ::::* Two additional O2ks (4 chambers) are devoted to instrumental development.
@@ Line 26: / Line 25: @@
-=== The DSL-Oroboros Research Laboratory ===
+=== Joint projects ===
-:::: '''16 O2k-Chambers (8 O2k)'''
+{| style="color: black;  width: 90%"
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[Functional Mitochondrial Diagnostics]]''' (VASCage)
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Hardorp Rebecka.jpg|'''[[Hardorp Rebecka|Rebecka Hardorp]]'''
+File:Romero Martinez Alejandra.jpeg|'''[[Romero Martinez Alejandra|Alejandra Romero-Martinez, Dr.]]'''
+File:Wieser-Insole J.jpg|'''[[Wieser-Insole Joshua|Joshua Wieser-Insole]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #ffffff" | '''[[ALAS]]'''
+| style="text-align: center;  background-color: #EFF5FB" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Profile-icon-9.png|'''[[Pfleger Ana|Ana Pfleger, Mag. ]]'''
+File:Roach_T.jpg|'''[[Roach Thomas|Thomas Roach, PhD ]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[TissueModels]]'''
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
-:::: The '''DSL-Oroboros Research Laboratory''' at the Daniel Swarovski Research Laboratory (DSL), Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck is equipped by Oroboros Instruments with eight O2k-FluoRespirometers (16 chambers), particularly devoted to mitochondrial research on human biopsies, cells isolated from blood samples, and cultured cells.
+File:Keller M.PNG|'''[[Keller Markus A| Markus Keller, Dr.]]'''
-:::: '''Oroboros Instruments''' collaborates closely with research labs of the Medical University of Innsbruck, the Ludwig-Franzens University of Innsbruck, and with visiting scientists from numerous international research institutions.
+File:IOC 2366 cropped.jpg|'''[[Smaling Anna|Anna Smaling, MRes]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #ffffff" | '''[[MitoKIN]]'''
+| style="text-align: center;  background-color: #EFF5FB" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
+File:Stefan E.jpg|'''[[Stefan Eduard|Eduard Stefan, PhD]]'''
+File:Profile-icon-9.png|'''[[Strich Sophie|Sophie Strich]]'''
+File:Torres-QuesadaO.jpg|'''[[Torres-Quesada O|Omar Torres-Quesada, PhD]]'''
+</gallery>
+|-
+| style="text-align: left;  background-color: #EFF5FB" | '''[[CureMILS]]'''
+| style="text-align: center;  background-color: #ffffff" |
+<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
-=== OXPHOS analysis ===
+File:Suarez.png|'''[[Suarez-Cubero Marta|Marta Suarez-Cubero]]'''
+</gallery>
+|}
+== OXPHOS analysis ==
 :::: SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
@@ Line 42: / Line 79: @@
 ::::» [[Projects|'''Current projects''']]
-::::» [['''Partners in the Oroboros Ecosystem''']]
+::::» '''[[Partners in the Oroboros Ecosystem]]'''
 ::::» [[Oroboros Laboratories: visiting scientists |'''Visiting scientists''']]
+== Keywords ==
+{{Keywords: Oroboros Laboratories}}