Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Difference between revisions of "Oroboros Laboratory"

From Bioblast
(31 intermediate revisions by 8 users not shown)
Line 1: Line 1:
{{Template:OROBOROS header page name}}
{{Template:OROBOROS header page name}}
:::: <big>'''Two labs - one team'''</big>
{{Template:OROBOROS Slogan}}
[[File:OROBOROS MitoFit-Lab.jpg|left|240px |MitoFit Laboratory]]
 
[[Image:Logo MitoFit.jpg|right|180px|link=http://www.mitofit.org/index.php/MitoFit|MitoFit]]
:::: <big>'''Two labs - one team: Oroboros O2k-Laboratory and DSL-Oroboros Research Lab'''</big>
 
:::: <big>'''Scientists with a gentle touch of entrepreneurship'''</big>  
[[File:Lab in action.jpg|right|500px|Oroboros Laboratory]]
 
 
 
<!--[[File:OROBOROS MitoFit-Lab.jpg|left|240px |Oroboros O2k-Laboratory]]-->


__TOC__
__TOC__


== Oroboros O2k-Laboratory ==
:::: '''48 O2k-Chambers (24 O2k)'''


:::: The OROBOROS MitoFit Laboratory (MitoFit Lab, 'Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, that is probably the world-wide best equipped lab for high-resolution respirometry. The MitoFit Lab was opened during the course of the K-Regio project [[MitoCom_O2k-Fluorometer| MitoCom Tyrol]], June 2013. It comprises 140 sqm which are divided into the office and research areas.  
:::: The '''Oroboros O2k-Laboratory''' ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project [[MitoCom_O2k-Fluorometer| MitoCom Tyrol]] in June 2013. It comprises 140 sqm which are divided into the office and research areas.  
 
::::* Twenty four O2k instruments for HRR (48 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.
 
::::* Two additional O2ks (4 chambers) are devoted to instrumental development.
 
::::* According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.
 
::::» ''More details:'' [[O2k-technical_support_and_open_innovation|Oroboros Support]]
 
 
=== Collaborators in the Oroboros Ecosystem ===
{| style="color: black;  width: 90%"
|-
| style="text-align: center;  background-color: #EFF5FB" | '''Collaborations'''
| style="text-align: center;  background-color: #ffffff" |
<gallery heights="165px" mode="nolines" perrow="6" widths="192px">
Image:LiebscherG.JPG|'''[[Liebscher G|Gudrun Liebscher]]''', MSc., PhD. student
Image:LemanG.JPG|'''[[Leman G|Géraldine Leman]]''', Postdoctoral researcher
File:Solmaz.png|'''[[Etemad S|Solmaz Etemad]]''', Postdoctoral researcher
Image:FischerC.JPG|'''[[Fischer C| Christine Fischer]]''', MSc., PhD. student
File:Lisa Bergmeister.jpg|'''[[Bergmeister L|Lisa Bergmeister]]''', PhD. student - [[SPIN]]
</gallery>
|}


=== O2k instruments ===
[[File:OROBOROS MitoFit Lab IMG 7638.JPG|right|500px |Lisi & Yvonne, MitoFit Laboratory]]
:::: '''28 O2k-Chambers (14 O2k)'''


::::* Twelve O2k instruments (24 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.


::::* Two additional O2ks (4 chambers) are devoted to instrumental development.


== The DSL-Oroboros Research Laboratory ==
:::: '''16 O2k-Chambers (8 O2k)'''
:::: {{Template:Oroboros Ecosystem Partner}}


::::» ''More details:'' [[O2k-technical_support_and_open_innovation|OROBOROS Support]]
:::: The '''DSL-Oroboros Research Laboratory''' at the Daniel Swarovski Research Laboratory (DSL), Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck is equipped by Oroboros Instruments with eight O2k-FluoRespirometers (16 chambers), particularly devoted to mitochondrial research on human biopsies, cells isolated from blood samples, and cultured cells.
:::: '''Oroboros Instruments''' collaborates closely with research labs of the Medical University of Innsbruck, the Ludwig-Franzens University of Innsbruck, and with visiting scientists from numerous international research institutions.




=== OXPHOS analysis ===
=== Bioenergetics Adventurers in the DSL-Oroboros Research Laboratory ===


:::: SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
{| style="color: black;  width: 90%"
|-
| style="text-align: center;  background-color: #ffffff" | '''[[Oroboros Laboratories |DSL-Oroboros Research Laboratory]]'''


::::* coupling control protocols in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
'''Medical University of Innsbruck'''
::::* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry|cell ergometry]]).
| style="text-align: center;  background-color: #EFF5FB" | <gallery heights="165px" mode="nolines" perrow="6" widths="192px">
Image:MeszarosA.JPG|'''[[Meszaros A|András Mészáros]]''', MD., PhD.<br/> - Mitochondrial Medicine Visionary
Image:David.jpg|'''[[Harrison DK| David Harrison]]''', Doz., PhD. - Independent scientific consultant
Image:MittelbergerC.JPG|'''[[Mittelberger C| Christa Mittelberger]]'''<br/> Student
Image:UnterwegerJ.JPG|'''[[Unterweger J| Jasmin Unterweger]]'''<br/> Student
Image:ReyerB.JPG|'''[[Reyer BA| Beatrix Ann Reyer]]'''<br/> Student
Image:HofmannJ.jpg|'''[[Hofmann J| Julia Hofmann]]'''<br/> Student
Image:Profile-icon-9.png|'''[[Buch M| Madita Buch]]'''<br/> Student
</gallery>




=== The MitoFit Centre of Excellence ===
|}


:::: OROBOROS INSTRUMENTS collaborates closely with research labs of the Medical University of Innsbruck, the Ludwig-Franzens University of Innsbruck, and with visiting scientists from numerous international research institutions.
== OXPHOS analysis ==


:::: According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world.
:::: SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using


[[File:ORO Lab 3.jpg|250px]] [[File:ORO Lab 4.jpg|250px]] [[File:ORO Lab 2.jpg|250px]]
::::* coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
::::* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry|cell ergometry]]).


::::» [[OROBOROS_Company#Current_projects |'''Current projects and collaborators''']]


::::» [[OROBOROS_MitoFit_lab:_visiting_scientists |'''Visiting scientists''']]
::::» [[Projects|'''Current projects''']]
::::» '''[[Partners in the Oroboros Ecosystem]]'''
::::» [[Oroboros Laboratories: visiting scientists |'''Visiting scientists''']]

Revision as of 14:04, 17 February 2020

                



Oroboros Laboratory

Mitochondria and Cell Research - the Oroboros Ecosystem
Two labs - one team: Oroboros O2k-Laboratory and DSL-Oroboros Research Lab
Scientists with a gentle touch of entrepreneurship
Oroboros Laboratory



Oroboros O2k-Laboratory

48 O2k-Chambers (24 O2k)
The Oroboros O2k-Laboratory ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project MitoCom Tyrol in June 2013. It comprises 140 sqm which are divided into the office and research areas.
  • Twenty four O2k instruments for HRR (48 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.
  • Two additional O2ks (4 chambers) are devoted to instrumental development.
  • According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.
» More details: Oroboros Support


Collaborators in the Oroboros Ecosystem

Collaborations



The DSL-Oroboros Research Laboratory

16 O2k-Chambers (8 O2k)
- a partner in the Oroboros Ecosystem
The DSL-Oroboros Research Laboratory at the Daniel Swarovski Research Laboratory (DSL), Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck is equipped by Oroboros Instruments with eight O2k-FluoRespirometers (16 chambers), particularly devoted to mitochondrial research on human biopsies, cells isolated from blood samples, and cultured cells.
Oroboros Instruments collaborates closely with research labs of the Medical University of Innsbruck, the Ludwig-Franzens University of Innsbruck, and with visiting scientists from numerous international research institutions.


Bioenergetics Adventurers in the DSL-Oroboros Research Laboratory

DSL-Oroboros Research Laboratory

Medical University of Innsbruck


OXPHOS analysis

SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
  • coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
  • various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping (cell ergometry).


» Current projects
» Partners in the Oroboros Ecosystem
» Visiting scientists