Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Oroboros Laboratory

From Bioblast
Revision as of 11:12, 9 February 2016 by Kandolf Georg (talk | contribs)

                



Oroboros Laboratory

MitoFit Laboratory
MitoFit

About us

The OROBOROS MitoFit Laboratory (MitoFit Lab, 'Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, that is probably the world-wide best equipped lab for high-resolution respirometry. The MitoFit Lab was opened during the course of the K-Regio project MitoCom Tyrol, starting in June 2013. It comprises 140 sqm which are divided into the office and research areas.

O2k instruments

24 O2k-Chambers (twelve O2k)

  • Twelve O2k instruments (24 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.
  • Two additional O2ks are devoted to instrumental development.


More details: OROBOROS Support


OXPHOS analysis

SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using

  • a phosphorylation control protocol in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
  • various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping (cell ergometry).


The MitoFit Centre of Excellence

OROBOROS INSTRUMENTS collaborates closely with research labs of the Medical University of Innsbruck, the Ludwig-Franzens University of Innsbruck, and with visiting scientists from numerous internation research institutions.

According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world.

ORO Lab 1.jpg ORO Lab 2.jpg ORO Lab 3.jpg ORO Lab 4.jpg


Current projects and collaborators

The OROBOROS-Team collaborates with:

MitoFit project

HoppelF.jpg
Florian Hoppel, MSc. - florian.hoppel@oroboros.at
PhD student
Institute for Sports Science and OROBOROS: O2k-MitoFit

O2k-MitoFit


Oncotyrol

Prostate cancer
The Oncotyrol research project has its focus on functional differences of mitochondria in human prostate tumor versus benign tissue, and comparison of primary tissue with cultured cells. - Oncotyrol
Project leader: A.Univ. Prof. Mag. Dr. Helmut Klocker, Dept. Urology, Medical University Innsbruck, Austria
Anja Weber, Mag., PhD student - anja.weber@i-med.ac.at
SchoepfB.jpg
Bernd Schoepf, Mag., PhD student -





Oncotyrol phasing out
Project leader: Univ.-Prof. Dr. Zlatko Trajanoski, Biozentrum Innsbruck - Sektion für Bioinformatik, Medical University Innsbruck, Austria


WeberB.JPG
Benno Weber, Mag., Scientific assistant - benno.weber@oncotyrol.at






LaschoberG.JPG
Gerhard Laschober, Mag., PhD, Postdoc - gerhard.laschober@i-med.ac.at






Pharmacology: mitochondrial function in brain tissues

Johannes Burtscher
Johannes Burtscher, Mag., PhD student
FWF projects W1206-B05 and I-977-B24.
Project leader: A.Univ. Prof. Dr. Christian Schwarzer, Dept. Pharmacology, Medical University Innsbruck, Austria



Internal Medicine

Chiara Volani, c_volani@yahoo.com
Project leader: Prof. Dr. Günther Weiss, Dept. of Internal Medicine, Medical University Innsbruck, Austria

Visiting scientists

» Visiting scientists in the MitoFit lab