Difference between revisions of "PBMC"
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|description='''Peripheral blood mononuclear cell''' (PBMC) is a fraction of the leucocyte population in the blood composed by cells with round nucleus. PBMC consist of lymphocytes (T, B and NK cells) and monocytes. During extraction, neutrophils and platelets can be found in the PBMC fraction. | |description='''Peripheral blood mononuclear cell''' (PBMC) is a fraction of the leucocyte population in the blood composed by cells with round nucleus. PBMC consist of lymphocytes (T, B and NK cells) and monocytes. During extraction, neutrophils and platelets can be found in the PBMC fraction. | ||
|info=[[MiPNet21.17 BloodCellsIsolation]] | |info=[[MiPNet21.17 BloodCellsIsolation]] | ||
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==Cell | == Cell size == | ||
* Lymphocytes: 210 fl of volume; 7 to 10 µm in diameter [1] | ::::* Lymphocytes: 210 fl of volume; 7 to 10 µm in diameter [1] | ||
::::* Monocytes: 180 fl of volume; 15 to 25 µm in diameter [2] | |||
== References == | |||
:::# [https://www.ncbi.nlm.nih.gov/pubmed/7214019| Segel GB, Cokelet GR, Lichtman MA (1981) The measurement of lymphocyte volume: importance of reference particle deformability and counting solution tonicity. Blood 57:894-9] | |||
:::# [https://www.ncbi.nlm.nih.gov/pubmed/19919621| Mardi D, Fwity B, Lobmann R, Ambrosch A (2010) Mean cell volume of neutrophils and monocytes compared with C-reactive protein, interleukin-6 and white blood cell count for prediction of sepsis and nonsystemic bacterial infections. Int J Lab Hematol 32:410-8] | |||
:::» [[O2k-Publications: PBMC]] | |||
Revision as of 08:28, 3 March 2020
Description
Peripheral blood mononuclear cell (PBMC) is a fraction of the leucocyte population in the blood composed by cells with round nucleus. PBMC consist of lymphocytes (T, B and NK cells) and monocytes. During extraction, neutrophils and platelets can be found in the PBMC fraction.
Abbreviation: PBMC
Reference: MiPNet21.17 BloodCellsIsolation
Cell size
- Lymphocytes: 210 fl of volume; 7 to 10 µm in diameter [1]
- Monocytes: 180 fl of volume; 15 to 25 µm in diameter [2]
References
- Segel GB, Cokelet GR, Lichtman MA (1981) The measurement of lymphocyte volume: importance of reference particle deformability and counting solution tonicity. Blood 57:894-9
- Mardi D, Fwity B, Lobmann R, Ambrosch A (2010) Mean cell volume of neutrophils and monocytes compared with C-reactive protein, interleukin-6 and white blood cell count for prediction of sepsis and nonsystemic bacterial infections. Int J Lab Hematol 32:410-8