PBMC

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MitoPedia

PBMC

Description

Peripheral blood mononuclear cell (PBMC) is a fraction of the leucocyte population in the blood composed by cells with round nucleus. PBMC consist of lymphocytes (T, B and NK cells) and monocytes. During extraction, neutrophils and platelets can be found in the PBMC fraction.

Abbreviation: PBMC

Reference: MiPNet21.17 BloodCellsIsolation



Cell size

  • Lymphocytes: 210 fl of volume; 7 to 10 µm in diameter [1]
  • Monocytes: 180 fl of volume; 15 to 25 µm in diameter [2]


References

  1. Segel GB, Cokelet GR, Lichtman MA (1981) The measurement of lymphocyte volume: importance of reference particle deformability and counting solution tonicity. Blood 57:894-9
  2. Mardi D, Fwity B, Lobmann R, Ambrosch A (2010) Mean cell volume of neutrophils and monocytes compared with C-reactive protein, interleukin-6 and white blood cell count for prediction of sepsis and nonsystemic bacterial infections. Int J Lab Hematol 32:410-8
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