Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

PGM-pathway control state

From Bioblast
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.


high-resolution terminology - matching measurements at high-resolution


PGM-pathway control state

Description

PGM

PGM: Pyruvate & Glutamate & Malate.

MitoPathway control state: NADH electron transfer-pathway state

Pyruvate (P) is oxidatively decarboxylated to acetyl-CoA and CO2, yielding NADH catalyzed by pyruvate dehydrogenase. Malate (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). Glutamate&malate is a substrate combination supporting an N-linked pathway control state, when glutamate is transported into the mt-matrix via the glutamate-aspartate carrier and reacts with oxaloacetate in the transaminase reaction to form aspartate and oxoglutarate. Glutamate as the sole substrate is transported by the electroneutral glutamate-/OH- exchanger, and is oxidized in the mitochondrial matrix by glutamate dehydrogenase to α-ketoglutarate ( 2-oxoglutarate), representing the glutamate-anaplerotic pathway control state. 2-oxoglutarate (α-ketoglutarate) is formed from isocitrate (isocitrate dehydrogenase, from oxaloacetate and glutamate by the transaminase, and from glutamate by the glutamate dehydrogenase.

Abbreviation: PGM

Reference: Gnaiger 2020 BEC MitoPathways

More details
» NADH electron transfer-pathway state
» Additive effect of convergent electron flow
» Respiratory complexes - more than five
» Convergent electron flow


PGML

PGM pathway in the LEAK state can be evaluated in the following SUIT protocols:

PGMP

PGM pathway in the OXPHOS state can be evaluated in the following SUIT protocols:

PGME

PGM pathway in the ET state can be evaluated in the following SUIT protocols:


MitoPedia concepts: SUIT state