Panajatovic 2017 IOC124

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Role of PGC-1Ξ± associated mitochondrial biogenesis in statin-induced myotoxicity.

Link: Mitochondr Physiol Network 22.07

Panajatovic M, Singh F, Kraehenbuehl S, Bouitbir J (2017)

Event: IOC124

At the request of the authors, this abstract is not made available online.

β€’ Bioblast editor: Beno M, Kandolf G β€’ O2k-Network Lab: CH Basel Kraehenbuehl S, FR Strasbourg Zoll J

Labels: MiParea: Respiration, Genetic knockout;overexpression, Exercise physiology;nutrition;life style, Pharmacology;toxicology  Pathology: Myopathy 

Organism: Mouse  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 

Pathway: N, S, NS  HRR: Oxygraph-2k, O2k-Fluorometer 


  1. Bouitbir J, Charles AL, Echaniz-Laguna A, Kindo M, Daussin F, Auwerx J, Piquard F, Geny B, Zoll J (2012) Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1. Europ Heart J 33:1397-1407.
  2. Bouitbir J, Singh F, Charles AL, Schlagowski AI, Bonifacio A, Echaniz-Laguna A, Geny B, Krahenbuhl S, Zoll J (2016) Statins trigger mitochondrial reactive oxygen species-induced apoptosis in glycolytic skeletal muscle. Antioxid Redox Signal 24:84-98.


Clinical Pharmacology & Toxicology, Univ Hospital, 4031 Basel, Switzerland. -

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