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Difference between revisions of "Q-junction"

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{{MitoPedia
{{MitoPedia
|abbr=Q
|description=[[File:SUIT-catg FNSGp.jpg|right|300px|Q-junction]]
|description=[[File:SUITp-Catg NFSGp.jpg|right|300px|Q-junction]]
The '''Q-junction''' is a junction for [[convergent electron flow]] in the [[Electron transfer pathway]] (ET-pathway) from type N substrates and mt-matrix dehydrogenases through [[Complex I]] (CI), from type F substrates and FA oxidation through [[electron-transferring flavoprotein complex]] (CETF), from succinate (S) through [[Complex II]] (CII), from glycerophosphate (Gp) through [[glycerophosphate dehydrogenase complex]] (CGpDH), from choline through [[choline dehydrogenase]], from dihydro-orotate through [[dihydro-orotate dehydrogenase]], and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to [[Complex III]] (CIII) and [[Complex IV]] (CIV). The concept of the Q-junction, with the [[N-junction]] and [[F-junction]] upstream, provides the rationale for defining [[Electron-transfer-pathway state]]s and [[categories of SUIT protocols]].
The '''Q-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] (ETS) from [[Complex I]] (CI), [[Complex II]] (CII), [[electron-transferring flavoprotein complex]] (CETF), [[glycerophosphate dehydrogenase complex]] (CGpDH), [[choline dehydrogenase]], [[dihydro-orotate dehydrogenase]], and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further to [[Complex III]] (CIII). The concept of the Q-junction, [[N-junction]] and [[F-junction]] provides the rationale for defining [[categories of SUIT protocols]].  
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2020 BEC MitoPathways]]
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]]
|type=Respiration
}}
}}
{{MitoPedia concepts|type=Respiration
{{MitoPedia concepts
|mitopedia concept=MiP concept, SUIT concept
}}
}}
{{MitoPedia methods
{{MitoPedia methods
|mitopedia method=Respirometry
|mitopedia method=Respirometry
|type=Respiration
}}
{{MitoPedia O2k and high-resolution respirometry
|mitopedia O2k and high-resolution respirometry=SUIT protocol
|type=Respiration
}}
}}
{{MitoPedia topics
{{MitoPedia topics
|mitopedia topic=Enzyme
|mitopedia topic=Enzyme
|type=Respiration
}}
}}
[[File:Hatefi 1962 CI&II 2012.jpg|right|500px|Q-junction]]
Contributed by [[Gnaiger E]] 2010-08-15; edited 2016-02-12, 2016-03-28.
Convergent CI<small>&</small>II-linked electron flow at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single input pathways (upper panel: [[Gnaiger 2009 Int J Biochem Cell Biol |Gnaiger 2009]]; lower panel: [[Hatefi 1962 J Biol Chem-XLII]]). From Fig. 1.5 in [[Gnaiger 2014 MitoPathways]].
__TOC__
 
 
[[File:Hatefi 1962 NS 2012.jpg|right|500px|Q-junction]]
:::: Convergent [[NS-linked electron flow]] at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: [[Gnaiger 2009 Int J Biochem Cell Biol |Gnaiger 2009]]; lower panel: [[Hatefi 1962 J Biol Chem-XLII]]). Modified Figure in [[Gnaiger 2020 BEC MitoPathways]].
 
 
:::: ''More details:'' [[Respiratory_complexes#Respiratory_complexes_-_more_than_five |»Respiratory complexes - more than five]]
::::» [[O2k-Publications: Q-junction effect]]
 
<br /> <br /> <br /> <br /> <br /> <br />
== Keywords ==
{{Template:Keywords: Q}}
 


== [[SUITbrowser]] question: Q-junction ==
:::: Several [[SUIT]] protocols can be used to answer questions on additivity, or [[Convergent electron flow|convergence of electron flow]] to the Q-junction.
:::: The [https://suitbrowser.oroboros.at/ SUITbrowser] can be used to find the best [[SUIT]] protocols for different research questions, among those:


''More details:'' [[Respiratory_complexes#Respiratory_complexes_-_more_than_five |»Respiratory complexes - more than five]]  
::::* Q-junction ([[NS]])
:» [[O2k-Publications: Q-junction effect]]
::::* Q-junction ([[FNS]])
::::* Q-junction ([[FNSGp]])

Revision as of 17:42, 1 January 2021


high-resolution terminology - matching measurements at high-resolution


Q-junction

Description

Q-junction

The Q-junction is a junction for convergent electron flow in the Electron transfer pathway (ET-pathway) from type N substrates and mt-matrix dehydrogenases through Complex I (CI), from type F substrates and FA oxidation through electron-transferring flavoprotein complex (CETF), from succinate (S) through Complex II (CII), from glycerophosphate (Gp) through glycerophosphate dehydrogenase complex (CGpDH), from choline through choline dehydrogenase, from dihydro-orotate through dihydro-orotate dehydrogenase, and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to Complex III (CIII) and Complex IV (CIV). The concept of the Q-junction, with the N-junction and F-junction upstream, provides the rationale for defining Electron-transfer-pathway states and categories of SUIT protocols.


Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2020 BEC MitoPathways


MitoPedia concepts: MiP concept, SUIT concept 


MitoPedia methods: Respirometry 


MitoPedia topics: Enzyme 

Contributed by Gnaiger E 2010-08-15; edited 2016-02-12, 2016-03-28.


Q-junction
Convergent NS-linked electron flow at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: Gnaiger 2009; lower panel: Hatefi 1962 J Biol Chem-XLII). Modified Figure in Gnaiger 2020 BEC MitoPathways.


More details: »Respiratory complexes - more than five
» O2k-Publications: Q-junction effect







Keywords


Questions.jpg


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SUITbrowser question: Q-junction

Several SUIT protocols can be used to answer questions on additivity, or convergence of electron flow to the Q-junction.
The SUITbrowser can be used to find the best SUIT protocols for different research questions, among those:
  • Q-junction (NS)
  • Q-junction (FNS)
  • Q-junction (FNSGp)