Difference between revisions of "Q-junction"
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{{MitoPedia | {{MitoPedia | ||
|description=[[File:SUIT-catg FNSGp.jpg|right|300px|Q-junction]] | |description=[[File:SUIT-catg FNSGp.jpg|right|300px|Q-junction]] | ||
The '''Q-junction''' is a junction for [[convergent electron flow]] in the [[Electron transfer pathway]] (ET-pathway) from type N substrates and mt- | The '''Q-junction''' is a junction for [[convergent electron flow]] in the [[Electron transfer pathway]] (ET-pathway) from type N substrates and mt-matrix dehydrogenases through [[Complex I]] (CI), from type F substrates and FA oxidation through [[electron-transferring flavoprotein complex]] (CETF), from succinate (S) through [[Complex II]] (CII), from glycerophosphate (Gp) through [[glycerophosphate dehydrogenase complex]] (CGpDH), from choline through [[choline dehydrogenase]], from dihydro-orotate through [[dihydro-orotate dehydrogenase]], and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to [[Complex III]] (CIII) and [[Complex IV]] (CIV). The concept of the Q-junction, with the [[N-junction]] and [[F-junction]] upstream, provides the rationale for defining [[Electron-transfer-pathway state]]s and [[categories of SUIT protocols]]. | ||
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger | |info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2020 BEC MitoPathways]] | ||
}} | }} | ||
{{MitoPedia concepts | {{MitoPedia concepts | ||
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[[File:Hatefi 1962 NS 2012.jpg|right|500px|Q-junction]] | [[File:Hatefi 1962 NS 2012.jpg|right|500px|Q-junction]] | ||
:::: Convergent [[NS-linked electron flow]] at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: [[Gnaiger 2009 Int J Biochem Cell Biol |Gnaiger 2009]]; lower panel: [[Hatefi 1962 J Biol Chem-XLII]]). Modified | :::: Convergent [[NS-linked electron flow]] at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: [[Gnaiger 2009 Int J Biochem Cell Biol |Gnaiger 2009]]; lower panel: [[Hatefi 1962 J Biol Chem-XLII]]). Modified Figure in [[Gnaiger 2020 BEC MitoPathways]]. | ||
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== Keywords == | |||
{{Template:Keywords: Q}} | |||
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Revision as of 18:42, 1 January 2021
Description
The Q-junction is a junction for convergent electron flow in the Electron transfer pathway (ET-pathway) from type N substrates and mt-matrix dehydrogenases through Complex I (CI), from type F substrates and FA oxidation through electron-transferring flavoprotein complex (CETF), from succinate (S) through Complex II (CII), from glycerophosphate (Gp) through glycerophosphate dehydrogenase complex (CGpDH), from choline through choline dehydrogenase, from dihydro-orotate through dihydro-orotate dehydrogenase, and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to Complex III (CIII) and Complex IV (CIV). The concept of the Q-junction, with the N-junction and F-junction upstream, provides the rationale for defining Electron-transfer-pathway states and categories of SUIT protocols.
Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2020 BEC MitoPathways
MitoPedia concepts:
MiP concept,
SUIT concept
MitoPedia methods:
Respirometry
MitoPedia topics:
Enzyme
Contributed by Gnaiger E 2010-08-15; edited 2016-02-12, 2016-03-28.
- Convergent NS-linked electron flow at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: Gnaiger 2009; lower panel: Hatefi 1962 J Biol Chem-XLII). Modified Figure in Gnaiger 2020 BEC MitoPathways.
Keywords
- Bioblast links: Q - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Coenzyme Q
- » Coenzyme Q
- » Quinone, Ubiquinone Q; oxidized
- » Quinol, Ubiquinol QH2; reduced
- » Semiquinone
- » Coenzyme Q2
- » Q-redox state
- » Q-pools
- Coenzyme Q
- Mitochondrial pathways, respiratory Complexes, and Q
- » Q-cycle
- » Q-junction
- » Convergent electron flow
- » NS-pathway
- » FNS
- » FNSGp
- Mitochondrial pathways, respiratory Complexes, and Q
- NextGen-O2k and Q-Module
SUITbrowser question: Q-junction
- Several SUIT protocols can be used to answer questions on additivity, or convergence of electron flow to the Q-junction.
- The SUITbrowser can be used to find the best SUIT protocols for different research questions, among those: