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ROUTINE respiration

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In the intact cell, ROUTINE respiration in the physiological coupling state, R, is controlled by physiological energy demands, energy turnover and the degree of coupling to phosphorylation (intrinsic uncoupling and pathological dyscoupling). R and growth of cells is supported by exogenous substrates in culture media, or endogenous substrates in media without energy substrates.


References

  • Gnaiger E (2010) MitoPathways: Respiratory states and flux control ratios. Mitochondr. Physiol. Network 12.15: 1-5. [link]
  • Gnaiger E (2008) Polarographic oxygen sensors, the oxygraph and high-resolution respirometry to assess mitochondrial function. In: Mitochondrial Dysfunction in Drug-Induced Toxicity (Dykens JA, Will Y, eds) John Wiley: 327-352. [pdf]