- high-resolution terminology - matching measurements at high-resolution
Respiratory acceptor control ratio
Description
The respiratory acceptor control ratio (RCR) is defined as State 3/State 4 [1]. If State 3 is measured at saturating [ADP], RCR is the inverse of the OXPHOS control ratio, L/P (when State 3 is equivalent to the OXPHOS state, P). RCR is directly but non-linearly related to the OXPHOS coupling efficiency, j≈P = 1-L/P. Whereas the normalized flux ratio j≈P has boundaries from 0.0 to 1.0, RCR ranges from 1.0 to infinity, which needs to be considered when performing statistical analyses. In intact cells, the term RCR has been used for the ratio State 3u/State 4o, i.e. for the inverse L/E ratio [2,3]. Then for conceptual and statistical reasons, RCR should be replaced by the ETS coupling efficiency, j≈E= 1-L/E [4].
Abbreviation: RCR
Reference: Chance 1955 J Biol Chem-III, Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory control ratio
MitoPedia methods:
Respirometry
Compare
- OXPHOS coupling efficiency
- Discussion: OXPHOS versus ETS capacity.
- More details: »ETS coupling efficiency
- Discussion
References
- Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation: III. The steady state. J Biol Chem 217:409-27. - »Bioblast link«
- Hütter E, Renner K, Pfister G, Stöckl P, Jansen-Dürr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. Biochem J 380:919-28. - »Bioblast link«
- Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837–45. - »Bioblast link«
- Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 17.18. OROBOROS MiPNet Publications, Innsbruck. - »Bioblast link«
