Difference between revisions of "SF6847"
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|info=[[Chinopoulos 2014 Methods Enzymol]], [https://www.ncbi.nlm.nih.gov/pubmed/6498178 Terada 1984 Biochim Biophys Acta] | |info=[[Chinopoulos 2014 Methods Enzymol]], [https://www.ncbi.nlm.nih.gov/pubmed/6498178 Terada 1984 Biochim Biophys Acta] | ||
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|mitopedia topic=Uncoupler | |||
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{{MitoPedia topics|mitopedia topic=Uncoupler}} |
Revision as of 08:59, 19 August 2020
Description
SF 6847 (C18H22N2O), also known as tyrphostin A9 or malonoben, is a protonophore and a very potent uncoupler of oxidative phosphorylation, being used in the nM range. Like all uncouplers, SF 6847 concentrations must be titrated carefully to evaluated the optimum concentration for maximum stimulation of mitochondrial respiration, particularly to avoid inhibition of respiration at higher concentrations.
Abbreviation: SF6847
Reference: Chinopoulos 2014 Methods Enzymol, Terada 1984 Biochim Biophys Acta
MitoPedia topics:
Uncoupler