View source for Samper 2009 Free Radic Biol Med

{{Publication
|title=Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S (2009) Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med 46:387-96.
|info=[http://www.ncbi.nlm.nih.gov/pubmed/19038329 PMID: 19038329 Open Access]
|authors=Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S
|year=2009
|journal=Free Radic Biol Med
|abstract=Lymphomas adapt to their environment by undergoing a complex series of biochemical changes that are
currently not well understood. To better define these changes, we examined the gene expression and gene
ontology profiles of thymic lymphomas from a commonly used model of carcinogenesis, the p53−/− mouse.
These tumors show a highly significant upregulation of mitochondrial biogenesis, mitochondrial protein
translation, mtDNA copy number, reactive oxygen species, antioxidant defenses, proton transport, ATP
synthesis, hypoxia response, and glycolysis, indicating a fundamental change in the bioenergetic profile of
the transformed T cell. Our results suggest that T cell tumorigenesis involves a simultaneous upregulation of
mitochondrial biogenesis, mitochondrial respiration, and glycolytic activity. These processes would allow
cells to adapt to the stressful tumor environment by facilitating energy production and thereby promote
tumor growth. Understanding these adaptations is likely to result in improved therapeutic strategies for this
tumor type.
|keywords=Mitochondria, Reactive oxygen species, Glycolysis, Lymphoma, p53, c-myc, Free radicals
|mipnetlab=ES Madrid Cadenas S
|discipline=Biomedicine
}}
{{Labeling
|area=Respiration, mt-Biogenesis;mt-density, Genetic knockout;overexpression
|diseases=Cancer
|injuries=Oxidative stress;RONS
|topics=Aerobic glycolysis
|couplingstates=OXPHOS, ET
|instruments=Oxygraph-2k
|discipline=Biomedicine
}}