https://wiki.oroboros.at/index.php?title=Sighel_2021_Cell_Rep&feed=atom&action=history
Sighel 2021 Cell Rep - Revision history
2024-03-28T20:11:42Z
Revision history for this page on the wiki
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https://wiki.oroboros.at/index.php?title=Sighel_2021_Cell_Rep&diff=219427&oldid=prev
Reiswig Regina at 11:11, 2 August 2021
2021-08-02T11:11:59Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:11, 2 August 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|title=Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://pubmed.ncbi.nlm.nih.gov/33910005/ PMID: 33910005 Open Access]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>|info=[https://pubmed.ncbi.nlm.nih.gov/33910005/ PMID: 33910005 Open Access]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sighel Denise, Notarangelo Michela, Aibara Shintaro, Re Angela, Ricci Gianluca, Guida Marianna, Soldano Alessia, Adami Valentina, Ambrosini Chiara, Broso Francesca, Rosatti Emanuele Filiberto, Longhi Sara, Buccarelli Mariachiara, D'Alessandris Quintino G, Giannetti Stefano, Pacioni Simone, Ricci-Vitiani Lucia, Rorbach Joanna, Pallini Roberto, Roulland Sandrine, Alexey, Mancini Ines, Modelska Angelika, Quattrone Alessandro</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>|authors=Sighel Denise, Notarangelo Michela, Aibara Shintaro, Re Angela, Ricci Gianluca, Guida Marianna, Soldano Alessia, Adami Valentina, Ambrosini Chiara, Broso Francesca, Rosatti Emanuele Filiberto, Longhi Sara, Buccarelli Mariachiara, D'Alessandris Quintino G, Giannetti Stefano, Pacioni Simone, Ricci-Vitiani Lucia, Rorbach Joanna, Pallini Roberto, Roulland Sandrine, <ins style="font-weight: bold; text-decoration: none;">Amunts </ins>Alexey, Mancini Ines, Modelska Angelika, Quattrone Alessandro</div></td></tr>
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Reiswig Regina
https://wiki.oroboros.at/index.php?title=Sighel_2021_Cell_Rep&diff=219426&oldid=prev
Reiswig Regina at 11:10, 2 August 2021
2021-08-02T11:10:32Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:10, 2 August 2021</td>
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Reiswig Regina
https://wiki.oroboros.at/index.php?title=Sighel_2021_Cell_Rep&diff=219425&oldid=prev
Reiswig Regina at 11:08, 2 August 2021
2021-08-02T11:08:28Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:08, 2 August 2021</td>
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Reiswig Regina
https://wiki.oroboros.at/index.php?title=Sighel_2021_Cell_Rep&diff=219424&oldid=prev
Reiswig Regina: Created page with "{{Publication |title=Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG,..."
2021-08-02T11:05:47Z
<p>Created page with "{{Publication |title=Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG,..."</p>
<p><b>New page</b></p><div>{{Publication<br />
|title=Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024.<br />
|info=[https://pubmed.ncbi.nlm.nih.gov/33910005/ PMID: 33910005 Open Access]<br />
|authors=Sighel Denise, Notarangelo Michela, Aibara Shintaro, Re Angela, Ricci Gianluca, Guida Marianna, Soldano Alessia, Adami Valentina, Ambrosini Chiara, Broso Francesca, Rosatti Emanuele Filiberto, Longhi Sara, Buccarelli Mariachiara, D'Alessandris Quintino G, Giannetti Stefano, Pacioni Simone, Ricci-Vitiani Lucia, Rorbach Joanna, Pallini Roberto, Roulland Sandrine, Alexey, Mancini Ines, Modelska Angelika, Quattrone Alessandro<br />
|year=2021<br />
|journal=Cell Rep<br />
|abstract=Glioblastoma stem cells (GSCs) resist current glioblastoma (GBM) therapies. GSCs rely highly on oxidative phosphorylation (OXPHOS), whose function requires mitochondrial translation. Here we explore the therapeutic potential of targeting mitochondrial translation and report the results of high-content screening with putative blockers of mitochondrial ribosomes. We identify the bacterial antibiotic quinupristin/dalfopristin (Q/D) as an effective suppressor of GSC growth. Q/D also decreases the clonogenicity of GSCs ''in vitro'', consequently dysregulating the cell cycle and inducing apoptosis. Cryoelectron microscopy (cryo-EM) reveals that Q/D binds to the large mitoribosomal subunit, inhibiting mitochondrial protein synthesis and functionally dysregulating OXPHOS complexes. These data suggest that targeting mitochondrial translation could be explored to therapeutically suppress GSC growth in GBM and that Q/D could potentially be repurposed for cancer treatment.<br />
|keywords=OXPHOS, Cryo-EM, Dalfopristin, Drug repurposing, Glioblastoma, Glioblastoma stem cells, High-content screening, Mitochondrial translation, Mitoribosome, Quinupristin<br />
|editor=[[Reiswig R]]<br />
}}<br />
{{Labeling<br />
|area=Respiration, Pharmacology;toxicology<br />
|diseases=Cancer<br />
|organism=Human<br />
|tissues=Nervous system, Stem cells<br />
|preparations=Permeabilized cells, Intact cells<br />
|couplingstates=ROUTINE, OXPHOS<br />
|pathways=N, S, NS, ROX<br />
|instruments=Oxygraph-2k<br />
|additional=2021-08<br />
}}</div>
Reiswig Regina