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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Pham 2020 Eur J Appl Physiol	2020	Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Bundgaard 2020 J Exp Biol	2020	Bundgaard A, Qvortrup K, Rasmussen LJ, Fago A (2020) Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. J Exp Biol 222:jeb200410.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Amphibians	Heart
De-Souza 2020 J Biol Chem	2020	De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.	LEAK OXPHOS	N Gp NS ROX	Isolated mitochondria Intact cells	Caenorhabditis elegans Saccharomyces cerevisiae
Kanellopoulos 2020 Cell	2020	Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Drosophila	Nervous system Other cell lines
Szibor 2020 J Cell Mol Med	2020	Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gaertner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlueter KD, Jacobs HT(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48.	LEAK OXPHOS	N S CIV	Permeabilized tissue Isolated mitochondria	Mouse	Heart
Woodhead 2020 J Appl Physiol (1985)	2020	Woodhead JST, D'Souza RF, Hedges CP, Wan J, Berridge MV, Cameron-Smith D, Cohen P, Hickey AJR, Mitchell CJ, Merry TL (2020) High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol (1985) 128:1346-54.	OXPHOS	N NS	Permeabilized tissue	Human	Skeletal muscle
Gnad 2020 Cell Metab	2020	Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab 32:56-70.e7.	LEAK OXPHOS ET	N S	Permeabilized tissue	Mouse	Skeletal muscle
Vanweert 2020 J Clin Endocrinol Metab	2020	Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E (2020) Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab 106:e1827-36.	LEAK OXPHOS ET	F N	Permeabilized tissue	Human	Skeletal muscle
Lin 2020 Preprints	2020	Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567.	LEAK ROUTINE OXPHOS ET	F N S Gp NS ROX	Permeabilized cells Intact cells	Human	Platelet
Charles 2020 Nanomedicine (Lond)	2020	Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32.	LEAK OXPHOS	N S CIV ROX	Isolated mitochondria	Human	Endothelial;epithelial;mesothelial cell
Chausse 2020 Brain Behav Immun	2020	Chausse B, Lewen A, Poschet G, Kann O (2020) Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun 88:802-14.	LEAK OXPHOS	S	Permeabilized cells	Mouse	Nervous system
Hosmann 2020 Acta Neurochir (Wien)	2020	Hosmann A, Milivojev N, Dumitrescu S, Reinprecht A, Weidinger A, Kozlov AV (2020) Cerebral nitric oxide and mitochondrial function in patients suffering aneurysmal subarachnoid hemorrhage-a translational approach. Acta Neurochir (Wien) 163:139-49.	OXPHOS	N S CIV ROX	Homogenate	Rat	Nervous system
Mezeiova 2020 Eur J Med Chem	2020	Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J (2020) 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease. Eur J Med Chem 211:113112.	LEAK OXPHOS ET	ROX	Intact cells	Human	Neuroblastoma
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis	2020	Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Isolated mitochondria Intact cells	Rat	Liver Nervous system
Hayes 2020 Nutrients	2020	Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.	LEAK ROUTINE OXPHOS ET	N S Gp CIV ROX	Permeabilized cells Intact cells	Human	HeLa
Liu 2020 J Clin Invest	2020	Liu L, Ding C, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z (2020) Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest 130:4710-25.	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Song 2020 Obes Facts	2020	Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) Increased insulin sensitivity by high-altitude hypoxia in mice with high-fat diet-induced obesity is associated with activated AMPK signaling and subsequently enhanced mitochondrial biogenesis in skeletal muscles. Obes Facts 13:455-72.	LEAK OXPHOS	F N	Permeabilized tissue		Skeletal muscle
Pena 2020 Int J Chronic Dis	2020	Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Dubinin 2020 Biochim Biophys Acta Bioenerg	2020	Dubinin MV, Talanov EY, Tenkov KS, Starinets VS, Mikheeva IB, Belosludtsev KN (2020) Transport of Ca²⁺ and Ca²⁺-dependent permeability transition in heart mitochondria in the early stages of duchenne muscular dystrophy. Biochim Biophys Acta Bioenerg 1861:148250.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Heart
He 2020 Clin Transl Med	2020	He C, Gao P, Cui Y, Li Q, Li Y, Lu Z, Ma H, Zhao Y, Li L, Sun F, Chen, X, Jia H, Liu D, Yang G, Zheng H, Zhu Z (2020) Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes. Clin Transl Med 10:e205.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Nervous system
Frambach 2020 Biochim Biophys Acta Mol Basis Dis	2020	Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727.	LEAK OXPHOS	F N S Gp CIV Other combinations ROX	Permeabilized tissue	Mouse	Skeletal muscle
Krabbendam 2020 Cell Death Dis	2020	Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263.	LEAK OXPHOS	N S	Isolated mitochondria	Mouse	Nervous system
Brum 2020 Mol Neurobiol	2020	Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, Scussel R, Machado-de-Ávila RA, Dalla Corte CL, Soares FAA, Oliveira SM (2020) Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol Neurobiol 57:4202-17.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Nervous system
McCommis 2020 Nat Metab	2020	McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2:1232-47. https://doi.org/10.1038/s42255-020-00296-1	LEAK OXPHOS	F N S NS	Permeabilized tissue Isolated mitochondria	Mouse	Heart
Locatelli 2020 FASEB J	2020	Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria Intact cells	Human	Endothelial;epithelial;mesothelial cell
Ferreira 2020 PLoS Genet	2020	Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Liver
Coppin 2020 Cell Death Dis	2020	Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.	LEAK ROUTINE OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells Intact cells	Human	Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell
Souza da Silva 2020 Mol Neurobiol	2020	Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Keppner 2020 Thesis	2020	Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Weaver 2020 Biol Lett	2020	Weaver RJ, Carrion G, Nix R, Maeda GP, Rabinowitz S, Iverson ENK, Thueson K, Havird JC (2020) High mitochondrial mutation rates in Silene are associated with nuclear-mediated changes in mitochondrial physiology. Biol Lett 16:20200450.	LEAK OXPHOS	N S CIV NS	Isolated mitochondria	Plants
Hardee 2020 Mol Metab	2020	Hardee JP, Martins KJB, Miotto PM, Ryall JG, Gehrig SM, Reljic B, Naim T, Chung JD, Trieu J, Swiderski K, Philp AM, Philp A, Watt MJ, Stroud DA, Koopman R, Steinberg GR, Lynch GS (2020) Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity. Mol Metab 45:101157.	OXPHOS LEAK	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Miotto 2020 Am J Physiol Endocrinol Metab	2020	Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab 319:E345-53.	OXPHOS LEAK	N NS F	Permeabilized tissue	Rat	Skeletal muscle
Deleye 2020 J Biol Chem	2020	Deleye Y, Cotte AK, Hannou SA, Hennuyer N, Bernard L, Derudas B, Caron S, Legry V, Vallez E, Dorchies E, Martin N, Lancel S, Annicotte JS, Bantubungi K, Pourtier A, Raverdy V, Pattou F, Lefebvre P, Abbadie C, Staels B, Haas JT, Paumelle R (2020) CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway. J Biol Chem 295:17310-22.	LEAK OXPHOS	F N	Homogenate	Mouse	Liver
Grewal 2020 Exp Neurol	2020	Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Andrade 2020 Nutr Metab Cardiovasc Dis	2020	Andrade D, Oliveira G, Menezes L, Nascimento AL, Carvalho S, Stumbo AC, Thole A, Garcia-Souza É, Moura A, Carvalho L, Cortez E (2020) Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis 30:151-61.	LEAK OXPHOS	F N NS	Permeabilized tissue	Mouse	Heart
Le 2020 J Biol Chem	2020	Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria. J Biol Chem 295:12485-97.	LEAK OXPHOS	F N S NS	Intact organism	Human	Heart
OXPHOS capacity	2020	Gnaiger E (2020) OXPHOS P and State 3. Mitochondr Physiol Network (2016-07-15) last update 2020-11-08.	OXPHOS
Jian 2020 Cell Metab	2020	Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908. https://doi.org/10.1016/j.cmet.2020.04.011	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Mouse	Liver
Thome 2020 JCI Insight	2020	Thome T, Kumar RA, Burke SK, Khattri RB, Salyers ZR, Kelley RC, Coleman MD, Christou DD, Hepple RT, Scali ST, Ferreira LF, Ryan TE (2020) Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease. JCI Insight 6:e139826.	LEAK OXPHOS	F N S	Isolated mitochondria	Mouse	Skeletal muscle
Yadav 2020 Cell Death Dis	2020	Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Human	Heart Stem cells
Lantier 2020 Diabetes	2020	Lantier Louise, Williams Ashley S, Williams Ian M, Guerin Amanda, Bracy Deanna P, Goelzer Mickael, Foretz Marc, Viollet Benoit, Hughey Curtis C, Wasserman David H (2020) Reciprocity between skeletal muscle AMPK deletion and insulin action in diet-induced obese mice. Diabetes 69:1636-49.	OXPHOS	N	Permeabilized tissue	Mouse	Skeletal muscle
Russell 2020 Nutrients	2020	Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
Marquez 2020 J Am Heart Assoc	2020	Marquez AM, Morgan RW, Ko T, Landis WP, Hefti MM, Mavroudis CD, McManus MJ, Karlsson M, Starr J, Roberts AL, Lin Y, Nadkarni V, Licht DJ, Berg RA, Sutton RM, Kilbaugh TJ (2020) Oxygen exposure during cardiopulmonary resuscitation is associated with cerebral oxidative injury in a randomized, blinded, controlled, preclinical trial. J Am Heart Assoc 9:015032.	LEAK OXPHOS ET	N S CIV NS	Homogenate	Pig	Nervous system
Duong 2020 Mitochondrion	2020	Duong QV, Hoffman A, Zhong K, Dessinger MJ, Zhang Y, Bazil JN (2020) Calcium overload decreases net free radical emission in cardiac mitochondria. Mitochondrion 51:126-39.	LEAK OXPHOS ET	F N S	Isolated mitochondria	Guinea pig	Heart
Woessner 2020 J Appl Physiol (1985)	2020	Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Lopez 2020 Function (Oxf)	2020	Lopez R, Marzban B, Gao X, Lauinger E, Van den Bergh F, Whitesall SE, Converso-Baran K, Burant CF, Michele DE, Beard DA (2020) Impaired myocardial energetics causes mechanical dysfunction in decompensated failing hearts. Function (Oxf) 1:zqaa018.	LEAK OXPHOS	F N	Isolated mitochondria	Rat	Heart
Ehrlicher 2020 FASEB J	2020	Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18.	LEAK OXPHOS ET	F N S NS	Isolated mitochondria	Mouse	Skeletal muscle
Almoiliqy 2020 Acta Pharmacol Sin	2020	Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Endothelial;epithelial;mesothelial cell
Macedo 2020 FASEB J	2020	Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J 34:9972-81.	LEAK OXPHOS	F N CIV ROX	Intact organism Isolated mitochondria	Caenorhabditis elegans
Garcia 2020 Mol Hum Reprod	2020	Garcia BM, Machado TS, Carvalho KF, Nolasco P, Nociti RP, Del Collado M, Capo Bianco MJD, Grejo MP, Neto JDA, Sugiyama FHC, Tostes K, Pandey AK, Gonçalves LM, Perecin F, Meirelles FV, Ferraz JBS, Vanzela EC, Boschero AC, Guimarães FEG, Abdulkader F, Laurindo FRM, Kowaltowski AJ, Chiaratti MR (2020) Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. Mol Hum Reprod 26:938-52.	LEAK OXPHOS ET	S	Isolated mitochondria	Mouse	Liver
Szibor 2020 J Biol Chem	2020	Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97.	LEAK OXPHOS	N S Gp CIV NS ROX	Isolated mitochondria Intact cells	Mouse	Nervous system
Pajuelo 2020 Cells	2020	Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	HEK
Battaglia 2020 Cell Death Dis	2020	Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells	Rat	Nervous system
Stepanova 2020 Methods Cell Biol	2020	Stepanova A, Galkin A (2020) Measurement of mitochondrial H₂O₂ production under varying O₂ tensions. https://doi.org/10.1016/bs.mcb.2019.12.008	LEAK OXPHOS	S N Gp	Isolated mitochondria	Mouse	Nervous system
Makrecka-Kuka 2020 Cardiovasc Drugs Ther	2020	Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther 34:791-97.	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Heart
D'Urso 2020 Surg Endosc	2020	D'Urso A, Agnus V, Barberio M, Seeliger B, Marchegiani F, Charles AL, Geny B, Marescaux J, Mutter D, Diana M (2020) Computer-assisted quantification and visualization of bowel perfusion using fluorescence-based enhanced reality in left-sided colonic resections. Surg Endosc 35:4321-31.	LEAK OXPHOS	N NS		Human	Endothelial;epithelial;mesothelial cell
Tepp 2020 Biochim Biophys Acta Gen Subj	2020	Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Mouse	Heart Skeletal muscle
Maeda 2020 J Cell Mol Med	2020	Maeda H, Kami D, Maeda R, Murata Y, Jo JI, Kitani T, Tabata Y, Matoba S, Gojo S (2020) TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes. J Cell Mol Med 24:5007-20.	LEAK ROUTINE OXPHOS ET	N ROX	Isolated mitochondria Intact cells	Rat	Heart
Zhou 2020 Biomed Pharmacother	2020	Zhou J, Zhang Y, Li S, Zhou Q, Lu Y, Shi J, Liu J, Wu Q, Zhou S (2020) Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway. Biomed Pharmacother 129:110351.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Liver
Piel 2020 PLoS One	2020	Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Liver Platelet
Irion 2020 Stem Cells Int	2020	Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Heart
Lensu 2020 Nutrients	2020	Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Hafstad 2020 Antioxidants (Basel)	2020	Hafstad AD, Hansen SS, Lund J, Santos CXC, Boardman NT, Shah AM, Aasum E (2020) NADPH oxidase 2 mediates myocardial oxygen wasting in obesity. Antioxidants (Basel) 9:E171.	LEAK OXPHOS	F N	Isolated mitochondria	Mouse	Heart
Chen 2020 Biochim Biophys Acta Mol Basis Dis	2020	Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Parker 2020 Thesis	2020	Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Kunz 2020 J Biol Chem	2020	Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem 295:17441-59.	LEAK ROUTINE OXPHOS ET	N NS ROX S	Permeabilized tissue Intact cells	Mouse	Skeletal muscle
Wang 2020 J Mol Med (Berl)	2020	Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61.	LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Jayakumari 2020 J Diabetes	2020	Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Human	Heart
Fuchs 2020 J Funct Foods	2020	Fuchs C, Bakuradze T, Steinke R, Grewal R, Eckert GP, Richling E (2020) Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. J Funct Foods 70:103988.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Liver
Wu 2020 Chemosphere	2020	Wu F, Sokolov EP, Dellwig O, Sokolova IM (2020) Season-dependent effects of ZnO nanoparticles and elevated temperature on bioenergetics of the blue mussel Mytilus edulis. Chemosphere 263:127780.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Molluscs	Other cell lines
Purhonen 2020 Nat Commun	2020	Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Liver Kidney
Liu 2020 Am J Physiol Heart Circ Physiol	2020	Liu R, Jagannathan R, Sun L, Li F, Yang P, Lee J, Negi V, Perez-Garcia EM, Shiva S, Yechoor VK, Moulik M (2020) Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol 319:H89-99. https://doi.org/10.1152/ajpheart.00732.2019	LEAK OXPHOS	F N NS	Isolated mitochondria	Mouse	Heart
Hingst 2020 Mol Metab	2020	Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Vega 2020 Physiol Rep	2020	Vega RB, Brouwers B, Parsons SA, Stephens NA, Pino MF, Hodges A, Yi F, Yu G, Pratley RE, Smith SR, Sparks LM (2020) An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. Physiol Rep 8:e14416.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Kamarauskaite 2020 Biomed Res Int	2020	Kamarauskaite J, Baniene R, Trumbeckas D, Strazdauskas A, Trumbeckaite S (2020) Increased succinate accumulation induces ROS generation in in vivo ischemia/reperfusion-affected rat kidney mitochondria. Biomed Res Int 2020:8855585.	LEAK OXPHOS	N S		Rat	Kidney
Cornelissen 2020 Hum Mol Genet	2020	Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Fibroblast
Briones-Herrera 2020 Free Radic Biol Med	2020	Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Rat	Kidney
Courtes 2020 Brain Res Bull	2020	Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
P-L control efficiency	2020	Gnaiger E (2020) Cell ergometry: OXPHOS-control and ET-coupling efficiency. Mitochondr Physiol Network (2015-01-18) last update 2020-11-12.	LEAK OXPHOS
MitoEAGLE muscle 1	2020	Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08	LEAK OXPHOS ET	N NS S ROX	Permeabilized tissue	Human	Skeletal muscle
Burtscher 2020 eNeuro	2020	Burtscher J, Copin JC, Sandi C, Lashuel HA (2020) Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala. eNeuro 7:ENEURO.0110-20.2020.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Buch 2020 FASEB J	2020	Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70.	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Cipullo 2020 Nucleic Acids Res	2020	Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res 49:354-70.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	HEK
Woessner 2020 Thesis	2020	Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Oellermann 2020 Sci Rep	2020	Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202.	LEAK OXPHOS ET	N S NS	Homogenate	Crustaceans	Heart
Yurre 2020 Arq Bras Cardiol	2020	Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37.	LEAK OXPHOS	N NS ROX	Isolated mitochondria	Mouse	Heart
Fisher 2020 Placenta	2020	Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Human	Genital
Simard 2020 Metabolites	2020	Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363.	LEAK OXPHOS ET	N S Gp NS ROX	Permeabilized tissue	Drosophila
Dawson 2020 J Exp Biol	2020	Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Fishes	Lung;gill
Chandramouleeswaran 2020 PLoS One	2020	Chandramouleeswaran PM, Guha M, Shimonosono M, Whelan KA, Maekawa H, Sachdeva UM, Ruthel G, Mukherjee S, Engel N, Gonzalez MV, Garifallou J, Ohashi S, Klein-Szanto AJ, Mesaros CA, Blair IA, Pellegrino da Silva R, Hakonarson H, Noguchi E, Baur JA, Nakagawa H (2020) Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes. PLoS One 15:e0239625.	ROUTINE OXPHOS	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Endothelial;epithelial;mesothelial cell
Ost 2020 EMBO Rep	2020	Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Li Puma 2020 Am J Physiol Regul Integr Comp Physiol	2020	Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:972-80.	LEAK OXPHOS	N NS	Permeabilized tissue Homogenate Isolated mitochondria	Mouse	Heart Skeletal muscle
Weger 2020 Sci Rep	2020	Weger M, Alpern D, Cherix A, Ghosal S, Grosse J, Russeil J, Gruetter R, de Kloet ER, Deplancke B, Sandi C (2020) Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Sci Rep 10:18308.	OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Bertero 2020 Circ Res	2020	Bertero E, O'Rourke B, Maack C (2020) Mitochondria do not survive calcium overload during transplantation. Circ Res 126:784-86.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Skeletal muscle
Mahul-Mellier 2020 Proc Natl Acad Sci U S A	2020	Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA (2020) The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci U S A 117:4971-82.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Nervous system
Sowton 2020 Mol Genet Metab Rep	2020	Sowton AP, Padmanabhan N, Tunster SJ, McNally BD, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED (2020) Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Mol Genet Metab Rep 23:100580.	LEAK OXPHOS	N NS	Homogenate	Mouse	Liver
Smith 2020 J Biol Chem	2020	Smith CD, Schmidt CA, Lin CT, Fisher-Wellman KH, Neufer PD (2020) Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure. J Biol Chem 295:16207-16.	LEAK OXPHOS ET	F N	Isolated mitochondria	Mouse	Skeletal muscle
Rodriguez 2020 J Gerontol A Biol Sci Med Sci	2020	Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci 76:796-804.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Molluscs
Schoepf 2020 Nat Commun	2020	Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. https://doi.org/10.1038/s41467-020-15237-5	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Permeabilized tissue	Human	Genital Other cell lines
Abid 2020 FASEB J	2020	Abid H, Ryan ZC, Delmotte P, Sieck GC, Lanza IR (2020) Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways. FASEB J 34:14458-72.	LEAK OXPHOS	N S NS	Intact cells	Mouse	Skeletal muscle
Esselun 2020 Neuromolecular Med	2020	Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Friederich-Persson 2020 Am J Physiol Renal Physiol	2020	Friederich-Persson M, Persson P (2020) Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats. Am J Physiol Renal Physiol 318:F683-88.	LEAK OXPHOS	N Gp	Isolated mitochondria	Rat	Kidney
Cubizolle 2020 J Cell Mol Med	2020	Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P (2020) Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal. J Cell Mol Med 24:5057-69.	LEAK OXPHOS ET	N S CIV NS	Permeabilized cells	Rat	Endothelial;epithelial;mesothelial cell
Kapser-Fischer 2020 Thesis	2020	Kapser-Fischer IP (2020) Dietary interventions in C57BL/6 mice and their interplay with selected metabolic and genetic parameters. PhD Thesis 120.	LEAK OXPHOS		Homogenate	Mouse	Fat
Sharma 2020 Integr Cancer Ther	2020	Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437.	LEAK OXPHOS	N S	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Dawid 2020 Biochim Biophys Acta Bioenerg	2020	Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.	LEAK ROUTINE OXPHOS ET	N S Gp NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human Mouse	Nervous system HEK
Hroudova 2020 Mol Neurobiol	2020	Hroudová J, Nováková T, Korábečný J, Maliňák D, Górecki L, Fišar Z (2020) Effects of novel tacrine derivatives on mitochondrial energy metabolism and monoamine oxidase activity-in vitro study. Mol Neurobiol 58:1102-13.	OXPHOS	N S ROX	Isolated mitochondria	Pig	Nervous system
Hedges 2020 Biosci Rep	2020	Hedges CP, Pham T, Shetty B, Masson SWC, Hickey AJR, Shepherd PR, Merry TL (2020) Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function. https://doi.org/10.1042/bsr20201128	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Mohsin 2020 Arch Biochem Biophys	2020	Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299.	LEAK OXPHOS	N S	Permeabilized cells	Rat	Skeletal muscle
Feng 2020 Int J Biol Macromol	2020	Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol 155:524-34.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Hexapods
Belosludtsev 2020 Biochimie	2020	Belosludtsev KN, Belosludtseva NV, Kosareva EA, Talanov EY, Gudkov SV, Dubinin MV (2020) Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria. Biochimie 176:150-57.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Rat	Liver
Contreras Mostazo 2020 Cancers (Basel)	2020	Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV ROX	Permeabilized cells Intact cells	Human	Blood cells
Monaco 2020 Am J Physiol Endocrinol Metab	2020	Monaco CMF, Bellissimo CA, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ (2020) Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol Endocrinol Metab 318:E44-E51.	OXPHOS	N S	Permeabilized tissue	Human	Skeletal muscle
Xia 2020 Biomed Res Int	2020	Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1	LEAK OXPHOS ET	F N S Gp DQ CIV NS Other combinations ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria
Hoffmann 2020 J Clin Endocrinol Metab	2020	Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle Fat
Liu 2020 Cell Death Dis	2020	Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Endothelial;epithelial;mesothelial cell
Keller 2020 Oxid Med Cell Longev	2020	Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629.	LEAK OXPHOS ET	N NS	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Agil 2020 J Clin Med	2020	Agil A, Chayah M, Visiedo L, Navarro-Alarcon M, Rodríguez Ferrer JM, Tassi M, Reiter RJ, Fernández-Vázquez G (2020) Melatonin improves mitochondrial dynamics and function in the kidney of Zücker diabetic fatty rats. J Clin Med 9:E2916.	LEAK OXPHOS	N S	Isolated mitochondria	Rat	Kidney
Severo 2020 Life Sci	2020	Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Bose 2020 Aging Cell	2020	Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261.	LEAK OXPHOS	F N CIV NS ROX	Permeabilized tissue	Mouse	Heart
Doig 2020 Skelet Muscle	2020	Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD⁺ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Cecatto 2020 Toxicol In Vitro	2020	Cecatto C, Amaral AU, Roginski AC, Castilho RF, Wajner M (2020) Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. Toxicol In Vitro 62:104665.	LEAK OXPHOS ET	N S	Permeabilized tissue Isolated mitochondria	Rat	Skeletal muscle
Ulgherait 2020 Nat Commun	2020	Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Drosophila
Weber 2020 FASEB J	2020	Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (2020) Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J 34:11816-37.	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Liver
Palavicini 2020 JCI Insight	2020	Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Nervous system
Brand 2020 J Clin Med	2020	Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.	LEAK OXPHOS ET	N CIV ROX	Permeabilized cells	Human	Lymphocyte
Lozano 2020 Part Fibre Toxicol	2020	Lozano O, Silva-Platas C, Chapoy-Villanueva H, Pérez BE, Lees JG, Ramachandra CJA, Contreras-Torres FF, Lázaro-Alfaro A, Luna-Figueroa E, Bernal-Ramírez J, Gordillo-Galeano A, Benitez A, Oropeza-Almazán Y, Castillo EC, Koh PL, Hausenloy DJ, Lim SY, García-Rivas G (2020) Amorphous SiO₂ nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes. Part Fibre Toxicol 17:15.	LEAK OXPHOS ET	S	Isolated mitochondria	Rat Human	Heart
Boardman 2020 Am J Physiol Heart Circ Physiol	2020	Boardman NT, Pedersen TM, Rossvoll L, Hafstad AD, Aasum E (2020) Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance. Am J Physiol Heart Circ Physiol 319:H682-93.	LEAK OXPHOS	F N	Isolated mitochondria	Mouse	Heart
Gnaiger 2020 BEC MitoPathways	2020	Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5^th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells	Human Mouse	Heart Skeletal muscle Fibroblast
Madeo 2020 US Patent	2020	Madeo F, Eisenberg T, Stekovic S (2020) Use of spermidine for the enhancement of mitochondrial respiration. US Patent US20200054579 A1.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Heart
Baggio 2020 Neurotoxicology	2020	Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Zebrafish	Nervous system
Barsottini 2020 Commun Biol	2020	Barsottini MRO, Copsey A, Young L, Baroni RM, Cordeiro AT, Pereira GAG, Moore AL (2020) Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa. Commun Biol 3:263.	OXPHOS	F N S CIV		Protists
Mikulas 2020 Materials	2020	Mikulás K, Komlódi T, Földes A, Sváb G, Horváth G, Nagy AM, Ambrus A, Gyulai-Gaál Sz, Gera I, Hermann P, Varga G, Tretter L (2020) Bioenergetic Impairment of triethylene glycol dimethacrylate- (TEGDMA-) treated dental pulp stem cells (DPSCs) and isolated brain mitochondria are amended by redox compound methylene blue. Materials (Basel) 13(16):3472.	OXPHOS ET ROUTINE	N S ROX	Isolated mitochondria Permeabilized cells Intact cells	Guinea pig Human	Stem cells
Avila-Rojas 2020 Food Chem Toxicol	2020	Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Kidney
Stankova 2020 Int J Mol Sci	2020	Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.	LEAK OXPHOS	F N S Gp NS ROX	Homogenate	Mouse	Liver
Carvalho 2020 BMC Nutr	2020	Carvalho E, Adams SH, Borsheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Pig	Liver
Edmunds 2020 Mol Metab	2020	Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab 41:101051.	LEAK OXPHOS ET	F N ROX	Homogenate	Mouse	Liver
P/E control ratio	2020	Gnaiger E (2020) P/E from mouse to man. Mitochondr Physiol Network (2014-05-20) last update 2020-11-12.	OXPHOS ET
Burtscher 2020 Int J Mol Sci	2020	Burtscher J, Di Pardo A, Maglione V, Schwarzer C, Squitieri F (2020) Mitochondrial respiration changes in R6/2 Huntington's Disease model mice during aging in a brain region specific manner. Int J Mol Sci 21:5412.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Reutzel 2020 Oxid Med Cell Longev	2020	Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.	LEAK ET OXPHOS	N S CIV ROX	Isolated mitochondria	Mouse	Nervous system
Heinonen 2020 Sci Rep	2020	Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Pig	Heart
Wen 2020 Biomedicines	2020	Wen JJ, Cummins CB, Williams TP, Radhakrishnan RS (2020) The genetic evidence of burn-induced cardiac mitochondrial metabolism dysfunction . Biomedicines 8:E566.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Rat	Heart
Larsen 2020 Acta Physiol (Oxf)	2020	Larsen FJ, Schiffer TA, Zinner C, Willis SJ, Morales-Alamo D, Calbet J, Boushel R, Holmberg HC (2020) Mitochondrial oxygen affinity increases after sprint interval training and is related to the improvement in peak oxygen uptake. https://doi.org/10.1111/apha.13463	OXPHOS	N NS	Isolated mitochondria	Human	Skeletal muscle
Brunetta 2020 J Physiol	2020	Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71.	LEAK OXPHOS	N NS	Permeabilized tissue	Mouse	Fat
Mahalingam 2020 J Physiol	2020	Mahalingam S, Cheviron ZA, Storz JF, McClelland GB, Scott GR (2020) Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes. J Physiol 598:5411-26. https://doi.org/10.1113/JP280298	LEAK OXPHOS	F N S CIV NS	Isolated mitochondria	Mouse	Skeletal muscle
Zavadskis 2020 Pharmaceutics	2020	Zavadskis S, Weidinger A, Hanetseder D, Banerjee A, Schneider C, Wolbank S, Marolt Presen D, Kozlov AV (2020) Effect of diphenyleneiodonium chloride on intracellular reactive oxygen species metabolism with emphasis on NADPH oxidase and mitochondria in two therapeutically relevant human cell types. Pharmaceutics 13:E10.	LEAK OXPHOS ET	N S	Permeabilized cells	Human	Other cell lines
Gvozdjakova 2020 Diagnostics (Basel)	2020	Gvozdjáková A, Sumbalová Z, Kucharská J, Komlósi M, Rausová Z, Vančová O, Számošová M, Mojto V (2020) Platelet mitochondrial respiration, endogenous coenzyme Q₁₀ and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:176.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Politis-Barber 2020 Am J Physiol Endocrinol Metab	2020	Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87.	LEAK OXPHOS	F N Gp NS	Permeabilized cells	Mouse	Fat
No 2020 Pflugers Arch	2020	No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93.	LEAK OXPHOS	N NS	Permeabilized tissue	Rat	Heart
Venediktova 2020 Mitochondrion	2020	Venediktova NI, Mashchenko OV, Talanov EY, Belosludtseva NV, Mironova GD (2020) Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism. Mitochondrion 52:190-96.	LEAK OXPHOS	N NS	Isolated mitochondria	Rat	Liver
Pereira 2020 PLoS One	2020	Pereira GC, Lee L, Rawlings N, Ouwendijk J, Parker JE, Andrienko TN, Henley JM, Halestrap AP (2020) Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia. PLoS One 15:e0234653.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Heart
McLaughlin 2020b Sci Rep	2020	McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Mouse	Heart Liver Kidney Fat
Hassan 2020 MitoFit Preprint Arch	2020	Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human
Pelster 2020 PLoS One	2020	Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (Arapaima gigas). PLoS One 15:e0236507.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Kidney Lung;gill
Piel 2020 FEBS J	2020	Piel MS, Masscheleyn S, Bouillaud F, Moncoq K, Miroux B (2020) Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant. FEBS J 288:3024-33.	LEAK OXPHOS ET		Permeabilized cells	Saccharomyces cerevisiae
Hraoui 2020 J Exp Biol	2020	Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Molluscs	Lung;gill
Xiong 2020 Biomed Pharmacother	2020	Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218.	LEAK OXPHOS ET	N S NS	Permeabilized cells	Human Rat	Endothelial;epithelial;mesothelial cell
Chang 2020 J Biol Chem	2020	Chang L, Liu X, Diggle CP, Boyle JP, Hopkins PM, Shaw MA, Allen PD (2020) Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia. J Biol Chem 295:15226-35.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Al-Azab 2020 FEBS J	2020	Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.	LEAK ROUTINE OXPHOS ET	N ROX	Permeabilized cells Intact cells	Human	Other cell lines
Vaccari 2020 Eur J Appl Physiol	2020	Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol 120:1787-803.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Skeletal muscle
Rodrigues 2020 J Appl Physiol (1985)	2020	Rodrigues GC, Rocha NN, Maia LA, Melo I, Simões AC, Antunes MA, Bloise FF, Woyames J, da-Silva WS, Capelozzi VL, Abela G, Ball L, Pelosi P, Rocco PRM, Silva PL (2020) Impact of experimental obesity on diaphragm structure, function and bioenergetics. J Appl Physiol (1985) 129:1062-74.	LEAK OXPHOS ET	N CIV NS	Permeabilized tissue	Rat	Skeletal muscle
MiPNet18.05 Amplex-Mouse-heart	2019-06-24	O2k-Fluorometry: HRR and H₂O₂ production in mouse cardiac tissue homogenate.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
MiPNet20.14 AmplexRed H2O2-production	2019-06-24	O2k-FluoRespirometry: HRR and simultaneous determination of H₂O₂ production with Amplex UltraRed.	LEAK OXPHOS ET	S	Isolated mitochondria	Mouse	Heart
Thome 2019 Am J Physiol Cell Physiol	2019	Thome T, Salyers ZR, Kumar RA, Hahn D, Berru FN, Ferreira LF, Scali ST, Ryan TE (2019) Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity. Am J Physiol Cell Physiol 317:C701-13.	LEAK ROUTINE OXPHOS ET	N NS ROX	Isolated mitochondria Intact cells	Mouse	Skeletal muscle
Catalao 2019 Brain Res	2019	Catalão CHR, Souza AO, Santos-Júnior NN, da Silva SC, da Costa LHA, Alberici LC, Rocha MJA, da Silva Lopes L (2019) Kaolin-induced hydrocephalus causes acetylcholinesterase activity dysfunction following hypothalamic damage in infant rats. Brain Res 1724:146408.	LEAK OXPHOS ET	N ROX	Homogenate	Rat	Nervous system
Chang 2019 Br J Anaesth	2019	Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.	LEAK OXPHOS ET	N S CIV NS ROX		Human	Skeletal muscle
Park 2019 Behav Brain Res	2019	Park SS, Park HS, Kim CJ, Baek SS, Kim TW (2019) Exercise attenuates maternal separation-induced mood disorder-like behaviors by enhancing mitochondrial functions and neuroplasticity in the dorsal raphe. Behav Brain Res 372:112049.	LEAK OXPHOS	N NS		Rat	Nervous system
McMurray 2019 FASEB J	2019	McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26.	LEAK OXPHOS	F N S CIV ROX	Permeabilized tissue	Mouse	Skeletal muscle
Langley 2019 Biochim Biophys Acta Mol Basis Dis	2019	Langley MR, Yoon H, Kim HN, Choi CI, Simon W, Kleppe L, Lanza IR, LeBrasseur NK, Matveyenko A, Scarisbrick IA (2019) High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system. Biochim Biophys Acta Mol Basis Dis 1866:165630.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Nervous system
Gonzalez-Mariscal 2019 FASEB J	2019	González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Monteiro 2019 Thesis	2019	Monteiro ARB (2019) Effects of resistance training on mitochondrial function and gene expression of UCP-3 in muscles of ovariectomized rats. Dissertation 82.	LEAK OXPHOS ET	N	Permeabilized tissue	Rat	Skeletal muscle
Hirschi 2019 Biol Reprod	2019	Hirschi KM, Tsai KYF, Davis T, Clark JC, Knowlton MN, Bikman BT, Reynolds PR, Arroyo JA (2019) Growth arrest specific protein (Gas)-6/AXL signaling induces preeclampsia (PE) in rats. Biol Reprod 102:199-210.	LEAK OXPHOS ET	N S NS	Permeabilized cells Permeabilized tissue	Rat	Genital
Kirby 2019 Comp Biochem Physiol C Toxicol Pharmacol	2019	Kirby AR, Cox GK, Nelson D, Heuer RM, Stieglitz JD, Benetti DD, Grosell M, Crossley DA 2nd (2019) Acute crude oil exposure alters mitochondrial function and ADP affinity in cardiac muscle fibers of young adult Mahi-mahi (Coryphaena hippurus). Comp Biochem Physiol C Toxicol Pharmacol 218:88-95.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Heart
Tiebe 2019 Sci Rep	2019	Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Crebl2 regulates cell metabolism in muscle and liver cells. Sci Rep 9:19869.	LEAK OXPHOS ROUTINE	F N Gp ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle Liver
Manfredini 2019 Clin Sci (Lond)	2019	Manfredini A, Constantino L, Pinto MC, Michels M, Burger H, Kist LW, Silva MC, Gomes LM, Dominguini D, Steckert A, Simioni C, Bogo M, Streck E, Barichello T, de Quevedo J, Singer M, Ritter C, Dal-Pizzol F (2019) Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model. Clin Sci (Lond) 133:1993-2004.	LEAK OXPHOS	N NS	Permeabilized tissue	Rat	Nervous system
Halle 2019 Am J Physiol Regul Integr Comp Physiol	2019	Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue Intact cells	Mouse	Skeletal muscle Liver Fat
Gururaja Rao 2019 Cells	2019	Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BK_Ca (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Drosophila
Pharaoh 2019 Mol Neurobiol	2019	Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue Isolated mitochondria Intact cells	Mouse	Skeletal muscle Nervous system Fat
McBride 2019 Arch Biochem Biophys	2019	McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.	LEAK OXPHOS	F N CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Wiberg 2019 Eur Heart J Acute Cardiovasc Care	2019	Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care 9:S138-44.	OXPHOS ET LEAK	N NS	Permeabilized tissue	Human	Skeletal muscle
Lemieux 2019 bioRxiv	2019	Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse	Blood cells
Boardman 2019 Can J Physiol Pharmacol	2019	Boardman NT, Falck AT, Lund T, Chu X, Martin-Armas M, Norvik JV, Jenssen TG, Ytrehus K (2019) Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress. Can J Physiol Pharmacol 98:139-46.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Heart
Mitroshina 2019 Oxid Med Cell Longev	2019	Mitroshina EV, Mishchenko TA, Shirokova OM, Astrakhanova TA, Loginova MM, Epifanova EA, Babaev AA, Tarabykin VS, Vedunova MV (2019) Intracellular neuroprotective mechanisms in neuron-glial networks mediated by glial cell line-derived neurotrophic factor. Oxid Med Cell Longev 2019:1036907.	LEAK OXPHOS	N NS	Isolated mitochondria	Mouse	Nervous system
Silva Ramos 2019 PLoS Genet	2019	Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085.	LEAK OXPHOS ET	N S Gp	Permeabilized cells Isolated mitochondria	Mouse	Heart Fibroblast
Turnbull 2019 Am J Physiol Cell Physiol	2019	Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol 317:C1278-88.	LEAK OXPHOS	N	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Salin 2019 Proc Biol Sci	2019	Salin K, Villasevil EM, Anderson GJ, Lamarre SG, Melanson CA, McCarthy I, Selman C, Metcalfe NB (2019) Differences in mitochondrial efficiency explain individual variation in growth performance. Proc Biol Sci 286:20191466.	OXPHOS	N CIV NS	Homogenate	Fishes	Skeletal muscle Liver
Fisher-Wellman 2019 Cell Rep	2019	Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.	LEAK OXPHOS ET	F N S Gp	Isolated mitochondria	Mouse	Heart Skeletal muscle
Kwak 2019 Int J Environ Res Public Health	2019	Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN (2019) Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. Int J Environ Res Public Health 16:E1157.	LEAK OXPHOS ET	F N NS	Permeabilized cells	Human	Skeletal muscle
Kopinski 2019 Proc Natl Acad Sci U S A	2019	Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Other cell lines
Sabogal-Guaqueta 2019 Biomed Pharmacother	2019	Sabogal-Guáqueta AM, Hobbie F, Keerthi A, Oun A, Kortholt A, Boddeke E, Dolga A (2019) Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomed Pharmacother 118:109295.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Nervous system
Monteiro 2019 J Bioenerg Biomembr	2019	Monteiro J, Assis-de-Lemos G, de-Souza-Ferreira E, Marques AM, Neves GA, Silveira MS, Galina A (2019) Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. J Bioenerg Biomembr 52:1-15.	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Mouse	Nervous system
Pedrotti 2019 Sci Adv	2019	Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells	Mouse	Fat
Rodinova 2019 Dis Model Mech	2019	Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.	LEAK OXPHOS ET	N S CIV ROX	Isolated mitochondria	Pig	Skeletal muscle
Dollerup 2019 J Physiol	2019	Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
D'Amico 2019 Mol Cell	2019	D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J (2019) The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Mol Cell 73:775-87.	OXPHOS	S NS ROX	Homogenate	Mouse	Skeletal muscle
Thomas 2019 Redox Biol	2019	Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155.	LEAK OXPHOS ET	N S NS ROX	Intact cells	Rat	Liver
Chiurillo 2019 Mol Biol Cell	2019	Chiurillo MA, Lander N, Bertolini MS, Vercesi AE, Docampo R (2019) Functional analysis and importance for host cell infection of the Ca²⁺-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi. Mol Biol Cell 30:1676-90.	LEAK OXPHOS ET	S	Permeabilized cells	Protists
Dent 2019 J Appl Physiol (1985)	2019	Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) 127:1117-27.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Greenway 2019 J Evol Biol	2019	Greenway EVG, Cirino LA, Wilner D, Somjee U, Anagnostou ME, Hepple RT, Miller CW (2019) Extreme variation in testes size in an insect is linked to recent mating activity. J Evol Biol 33:142-50.	LEAK OXPHOS	N CIV NS ROX	Permeabilized cells	Hexapods	Genital
Hughes 2019 J Physiol	2019	Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR (2019) Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy. J Physiol 598:1377-92.	OXPHOS LEAK	N NS	Permeabilized tissue	Mouse	Heart
Fernando 2019 Exp Gerontol	2019	Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Ruegsegger 2019 JCI Insight	2019	Ruegsegger GN, Vanderboom PM, Dasari S, Klaus KA, Kabiraj P, McCarthy CB, Lucchinetti CF, Nair KS (2019) Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. JCI Insight 4:130681.	LEAK OXPHOS ET	ROX	Isolated mitochondria	Mouse	Nervous system
Courtes 2019 Biomed Pharmacother	2019	Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca²⁺-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46.	OXPHOS LEAK	N S NS ROX	Isolated mitochondria	Rat	Liver
Halling 2019 Am J Physiol Endocrinol Metab	2019	Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Grandoch 2019 Nat Metab	2019	Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW (2019) 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1:546-59.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Fat
Bodis 2019 J Clin Endocrinol Metab	2019	Bodis K, Jelenik T, Lundbom J, Markgraf DF, Strom A, Zaharia OP, Karusheva Y, Burkart V, Muessig K, Kupriyanova Y, Ouni M, Wolkersdorfer M, Hwang JH, Ziegler D, Schuermann A, Roden M, Szendroedi J (2019) Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes. J Clin Endocrinol Metab 105:dgz267.	LEAK OXPHOS ET	F N NS	Permeabilized cells	Human	Fat
Huerta 2019 Aquat Toxicol	2019	Huerta B, Chung-Davidson YW, Bussy U, Zhang Y, Bazil JN, Li W (2019) Sea lamprey cardiac mitochondrial bioenergetics after exposure to TFM and its metabolites. Aquat Toxicol 219:105380.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Fishes	Heart
Calabria 2019 Front Neurosci	2019	Calabria Elisa, Scambi Ilaria, Bonafede Roberta, Schiaffino Lorenzo, Peroni Daniele, Potrich Valentina, Capelli Carlo, Schena Federico, Mariotti Raffaella (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an in vitro model of ALS. Front Neurosci 13:1070.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Nervous system
Fowler 2019 Int J Mol Sci	2019	Fowler ED, Hauton D, Boyle J, Egginton S, Steele DS, White E (2019) Energy metabolism in the failing right ventricle: limitations of oxygen delivery and the creatine kinase system . Int J Mol Sci 20:1805.	OXPHOS		Permeabilized cells	Rat	Heart
Scavuzzo 2019 J Neurophysiol	2019	Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Nervous system
Macedo 2019 Biochim Biophys Acta Mol Cell Biol Lipids	2019	Macedo F, Martins GL, Luévano-Martínez LA, Viana GM, Riske KA, Inague A, Yoshinaga MY, Aguilaniu H, Miyamoto S, Glezer I, da Cunha FM (2019) Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158539.	LEAK OXPHOS	N CIV NS	Isolated mitochondria	Caenorhabditis elegans
Petrick 2019 Biochem J	2019	Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58.	OXPHOS LEAK	F N NS	Permeabilized tissue	Mouse	Skeletal muscle
Cedrone 2019 Thesis	2019	Cedrone M (2019) Low birth weight and post-natal diet induced alterations in skeletal muscle oxygen consumption and fiber type composition. Master's Thesis 83.	LEAK OXPHOS	N S	Permeabilized tissue Intact cells	Guinea pig Mouse	Skeletal muscle
Jaskiewicz 2019 J Clin Med	2019	Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694.	ROUTINE OXPHOS ET LEAK	N S NS ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle Other cell lines
Jaiswal 2019 Mol Metab	2019	Jaiswal N, Gavin MG, Quinn WJ 3rd, Luongo TS, Gelfer RG, Baur JA, Titchenell PM (2019) The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Mol Metab 28:1-13.	LEAK OXPHOS	N	Isolated mitochondria	Mouse	Skeletal muscle
Deutschman 2019 J Cell Sci	2019	Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Tyrrell 2019 Circ Res	2019	Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314.	OXPHOS ET	N S NS ROX		Mouse	Endothelial;epithelial;mesothelial cell
Paumelle 2019 J Hepatol	2019	Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.	OXPHOS LEAK	F N	Homogenate	Human	Liver
Garcia-Roche 2019 PLoS One	2019	García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780.	LEAK OXPHOS ET	N S NS ROX	Intact cells	Bovines	Liver
Christian 2019 Respir Physiol Neurobiol	2019	Christian AR, Losantos-Ramos K, Marcelino G, Daniela F, Jorge S (2019) NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent. Respir Physiol Neurobiol 266:156-62.	LEAK OXPHOS	N	Permeabilized tissue	Mouse	Nervous system
Rutai 2019 Shock	2019	Rutai A, Fejes R, Juhász L, Tallósy SP, Poles MZ, Földesi I, Mészáros AT, Szabó A, Boros M, Kaszaki J (2019) Endothelin A and B receptors: Potential pargets for microcirculatory-mitochondrial therapy in experimental sepsis. Shock 54:87-95.	LEAK OXPHOS	N S ROX	Homogenate	Rat	Liver
Seo 2019 Exp Neurol	2019	Seo JH, Park HS, Park SS, Kim CJ, Kim DH, Kim TW (2019) Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Exp Neurol 322:113043.	LEAK OXPHOS	N NS	Isolated mitochondria	Rat	Nervous system
Wessels 2019 Obesity (Silver Spring)	2019	Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Human	Fat
Havird 2019 Mitochondrion	2019	Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11.	LEAK OXPHOS	N S CIV NS ROX	Isolated mitochondria	Plants
Brunetta 2019 J Funct Foods	2019	Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Shrum 2019 Biomolecules	2019	Shrum S, Rusch NJ, MacMillan-Crow LA (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury in vitro. Biomolecules 9:E825.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Rat	Kidney
Bettinazzi 2019 Proc Biol Sci	2019	Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708.	LEAK OXPHOS ET	N Gp CIV NS ROX	Permeabilized cells	Molluscs	Lung;gill Genital
Power 2019 PLoS One	2019	Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML (2019) Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment. PLoS One 14:e0214740.	LEAK OXPHOS	N NS	Permeabilized tissue	Rat	Heart
Andreazza 2019 Nat Commun	2019	Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, Whitworth AJ (2019) Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila. https://doi.org/10.1038/s41467-019-10857-y	OXPHOS	N S	Homogenate	Drosophila
Mayeuf-Louchart 2019 Cell Rep	2019	Mayeuf-Louchart A, Lancel S, Sebti Y, Pourcet B, Loyens A, Delhaye S, Duhem C, Beauchamp J, Ferri L, Thorel Q, Boulinguiez A, Zecchin M, Dubois-Chevalier J, Eeckhoute J, Vaughn LT, Roach PJ, Dani C, Pederson BA, Vincent SD, Staels B, Duez H (2019) Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation. Cell Rep 29:1410-18.	LEAK OXPHOS	F N S NS	Permeabilized cells	Mouse	Fat
Rojas-Morales 2019 Free Radic Biol Med	2019	Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67.	LEAK OXPHOS	N	Isolated mitochondria	Rat	Kidney
Holsgrove 2019 Thesis	2019	Holsgrove A (2019) The effect of temperature on cardiac energetics in the rainbow trout, Onchorhynchus mykiss. Phd Thesis 166.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Fishes	Heart
Bertolini 2019 MBio	2019	Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca²⁺ uptake, growth, and infectivity of the human pathogen Trypanosoma cruzi. MBio 10:e00348-19.	LEAK OXPHOS ET		Permeabilized cells	Protists
Zhang 2019 Biochem Biophys Res Commun	2019	Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Liver
Nambu 2019 Eur J Pharmacol	2019	Nambu H, Takada S, Fukushima A, Matsumoto J, Kakutani N, Maekawa S, Shirakawa R, Nakano I, Furihata T, Katayama T, Yamanashi K, Obata Y, Saito A, Yokota T, Kinugawa S (2019) Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure. Eur J Pharmacol 866:172810.	LEAK OXPHOS	F N NS	Permeabilized tissue	Mouse	Skeletal muscle
Ferreira 2019 Nat Commun	2019	Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun 10:329.	LEAK OXPHOS ET	NS	Isolated mitochondria	Rat	Heart
Sonjak 2019 J Gerontol A Biol Sci Med Sci	2019	Sonjak V, Jacob KJ, Spendiff S, Vuda M, Perez A, Miguez K, Minozzo FC, Spake C, Morais JA, Hepple RT (2019) Reduced mitochondrial content, elevated ROS, and modulation by denervation in skeletal muscle of pre-frail/frail elderly women. J Gerontol A Biol Sci Med Sci 74:1887-95.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Jansen 2019 Am J Physiol Heart Circ Physiol	2019	Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Heart
Chabi 2019 MitoFit Preprint Arch EA	2019	Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. https://doi.org/10.26124/mitofit:ea19.MitoEAGLE.0001	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Nunes 2019 Oxid Med Cell Longev	2019	Nunes MEM, Schimith LE, da Costa-Silva DG, Lopes AR, Leandro LP, Martins IK, de Mello RS, Hartmann DD, de Carvalho NR, Carvalho da Rosa P, Trevisan R, Di Giulio RT, Posser T, Franco JL (2019) Acute exposure to permethrin modulates behavioral functions, redox, and bioenergetics parameters and induces DNA damage and cell death in larval zebrafish. Oxid Med Cell Longev 2019:9149203.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Homogenate	Zebrafish
Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol	2019	Johansen JL, Esbaugh AJ (2019) Oil-induced responses of cardiac and red muscle mitochondria in red drum (Sciaenops ocellatus). Comp Biochem Physiol C Toxicol Pharmacol 219:35-41.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Fishes	Heart Skeletal muscle
Pino 2019 Physiol Genomics	2019	Pino MF, Stephens NA, Eroshkin AM, Yi F, Hodges A, Cornnell HH, Pratley RE, Smith SR, Wang M, Han X, Coen PM, Goodpaster BH, Sparks LM (2019) Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with type 2 diabetes. Physiol Genomics 51:586-95.	LEAK OXPHOS ET	N NS	Permeabilized cells Permeabilized tissue	Human	Skeletal muscle
Svensson 2019 Am J Physiol Endocrinol Metab	2019	Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S (2019) Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab 318:E145-51.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Kakimoto 2019 PLoS One	2019	Kakimoto PA, Chausse B, Caldeira da Silva CC, Donato Júnior J, Kowaltowski AJ (2019) Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One 14:e0211733.	LEAK OXPHOS	F NS	Isolated mitochondria	Mouse	Liver
Rose 2019 Am J Physiol Endocrinol Metab	2019	Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. https://doi.org/10.1152/ajpendo.00084.2019	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells Permeabilized tissue Intact cells	Human	Skeletal muscle Blood cells Platelet
Karusheva 2019 Am J Clin Nutr	2019	Karusheva Y, Koessler T, Strassburger K, Markgraf D, Mastrototaro L, Jelenik T, Simon MC, Pesta D, Zaharia OP, Bódis K, Bärenz F, Schmoll D, Wolkersdorfer M, Tura A, Pacini G, Burkart V, Müssig K, Szendroedi J, Roden M (2019) Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial. Am J Clin Nutr 110:1098-107.	LEAK OXPHOS ET	F N NS ROX	Permeabilized tissue Isolated mitochondria	Human	Skeletal muscle
Munro 2019 Aging Cell	2019	Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.	LEAK OXPHOS	N S NS	Isolated mitochondria	Mouse Other mammals	Heart Skeletal muscle
Bettinazzi 2019 Cryobiology	2019	Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.	LEAK OXPHOS ET	N Gp CIV NS ROX S Other combinations	Permeabilized tissue	Molluscs	Lung;gill
Campos 2019 Thesis	2019	Campos DF (2019) Os peixes amazônicos vivem perto dos seus limites térmicos? O efeito das mudanças climáticas sobre a ecofisiologia de peixes de Igarapé da Amazônia Central. PhD Thesis 106.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells	Fishes	Lung;gill

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