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From Bioblast
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Nunes 2019 Oxid Med Cell Longev2019Nunes MEM, Schimith LE, da Costa-Silva DG, Lopes AR, Leandro LP, Martins IK, de Mello RS, Hartmann DD, de Carvalho NR, Carvalho da Rosa P, Trevisan R, Di Giulio RT, Posser T, Franco JL (2019) Acute exposure to permethrin modulates behavioral functions, redox, and bioenergetics parameters and induces DNA damage and cell death in larval zebrafish. Oxid Med Cell Longev 2019:9149203.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafish
Zhu 2019 Aging Cell2019Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883.LEAK
OXPHOS
ET
N
NS
S
ROX
Isolated mitochondriaMouseLiver
Itkis 2019 Mitochondrion2019Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17.LEAK
ROUTINE
OXPHOS
ET
N
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanFibroblast
Rodinova 2019 Dis Model Mech2019Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.LEAK
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaPigSkeletal muscle
Isei 2019 Free Radic Biol Med2019Isei MO, Kamunde C (2019) Effects of copper and temperature on heart mitochondrial hydrogen peroxide production. Free Radic Biol Med 147:114-28.N
S
ROX
Isolated mitochondriaFishesHeart
De Moura Escobar 2019 Toxicol In Vitro2019de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro 61:104640.LEAK
OXPHOS
N
S
ROX
Permeabilized cellsHumanNeuroblastoma
Teh 2019 Mol Cancer Ther2019Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.LEAK
ROUTINE
OXPHOS
ET
N
S
DQ
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Human
Mouse
Other cell lines
Rocco-Machado 2019 Free Radic Biol Med2019Rocco-Machado N, Cosentino-Gomes D, Nascimento MT, Paes-Vieira L, Khan YA, Mittra B, Andrews NW, Meyer-Fernandes JR (2019) Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity. https://doi.org/10.1016/j.freeradbiomed.2019.08.026LEAK
ROUTINE
ET
ROXIntact organism
Intact cells
Protists
Berru 2019 Sci Rep2019Berru FN, Gray SE, Thome T, Kumar RA, Salyers ZR, Coleman M, Dennis Le, O'Malley K, Ferreira LF, Berceli SA, Scali ST, Ryan TE (2019) Chronic kidney disease exacerbates ischemic limb myopathy in mice via altered mitochondrial energetics. Sci Rep 9:15547.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Jansen 2019 Am J Physiol Heart Circ Physiol2019Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseHeart
Chroeis 2019 Basic Clin Pharmacol Toxicol2019Chroeis KM, Larsen S, Pedersen JS, Rygg MO, Boilsen AEB, Bendtsen F, Dela F (2019) Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue. https://doi.org/10.1111/bcpt.13304LEAK
OXPHOS
N
S
ROX
Intact cellsHumanLiver
Rose 2019 Am J Physiol Endocrinol Metab2019Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. https://doi.org/10.1152/ajpendo.00084.2019LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Permeabilized tissue
Intact cells
HumanSkeletal muscle
Blood cells
Platelet
Tiebe 2019 Sci Rep2019Tiebe M, Lutz M, Senyilmaz Tiebe D, Teleman AA (2019) Crebl2 regulates cell metabolism in muscle and liver cells. Sci Rep 9:19869.LEAK
OXPHOS
ROUTINE
F
N
Gp
ROX
Permeabilized cells
Intact cells
MouseSkeletal muscle
Liver
Reda 2019 Sci Rep2019Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Weinstein 2019 bioRxiv2019Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanOther cell lines
Lymphocyte
Zhao 2019 Basic Res Cardiol2019Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12.LEAK
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OXPHOS
ET
N
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ROX
Intact cells
Permeabilized cells
RatHeart
Fibroblast
Brunetta 2019 J Funct Foods2019Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Garcia-Roche 2019 PLoS One2019García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780.LEAK
OXPHOS
ET
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ROX
Intact cellsBovinesLiver
Cikankova 2019 Naunyn Schmiedebergs Arch Pharmacol2019Cikánková T, Fišar Z, Bakhouche Y, Ľupták M, Hroudová J (2019) In vitro effects of antipsychotics on mitochondrial respiration. Naunyn Schmiedebergs Arch Pharmacol 392:1209-23.OXPHOSN
S
ROX
Isolated mitochondriaPigNervous system
Latham 2019 J Anim Sci2019Latham CM, Fenger CK, White SH (2019) Rapid Communication: Differential skeletal muscle mitochondrial characteristics of weanling racing-bred horses. J Anim Sci [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHorseSkeletal muscle
Bajzikova 2019 Cell Metab2019Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. 10.1016/j.cmet.2018.10.014OXPHOS
ET
N
S
ROX
Permeabilized cells
Homogenate
MouseEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Blais-Lecours 2019 Am J Respir Cell Mol Biol2019Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Burgess JK, Halayko AJ, Soliz J, Marsolais D (2019) Metabolic adaptation of airway smooth muscle cells to a SPHK2 substrate precedes cytostasis. Am J Respir Cell Mol Biol 62:35-42.LEAK
ROUTINE
OXPHOS
ET
ROXIntact cellsHumanOther cell lines
Heden 2019 Sci Adv2019Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K (2019) Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity. Sci Adv 5:eaax8352.LEAK
OXPHOS
F
N
S
DQ
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol2019Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21.OXPHOS
ET
LEAK
N
S
Gp
CIV
NS
ROX
Permeabilized tissueOther invertebratesSkeletal muscle
Harhous 2019 J Mol Cell Cardiol2019Harhous Z, Badawi S, Bona NG, Pillot B, Augeul L, Paillard M, Booz GW, Canet-Soulas E, Ovize M, Kurdi M, Bidaux G (2019) Critical appraisal of STAT3 pattern in adult cardiomyocytes. J Mol Cell Cardiol 131:91-100.OXPHOS
ET
N
CIV
ROX
Isolated mitochondriaMouseHeart
Dannheisig 2019 Cells2019Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019) Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux. Cells 8:E894.LEAK
ROUTINE
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Skrivergaard 2019 Viruses2019Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122.LEAK
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OXPHOS
ET
N
S
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
HeLa
Alvarez 2019 Chem Biol Interact2019Álvarez Santos MR, Duarte YB, Güiza FM, Romero Bohórquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Perry 2019 J Mol Cell Cardiol2019Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.LEAK
OXPHOS
N
S
ROX
Isolated mitochondria
Permeabilized cells
RatHeart
Carteri 2019 Toxicol Lett2019Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseNervous system
Havird 2019 Mitochondrion2019Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11.LEAK
OXPHOS
N
S
CIV
NS
ROX
Isolated mitochondriaPlants
Qaed 2019 Oxid Med Cell Longev2019Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxid Med Cell Longev 2019:6521218.LEAK
OXPHOS
ET
ROUTINE
N
S
NS
ROX
Homogenate
Isolated mitochondria
Permeabilized cells
Intact cells
RatHeart
Mann 2019 Oncogene2019Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.LEAK
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OXPHOS
ET
N
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CIV
NS
ROX
F
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Ng 2019 J Biol Chem2019Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18.LEAK
OXPHOS
ET
N
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CIV
NS
ROX
Permeabilized cellsHumanNeuroblastoma
Courtes 2019 Biomed Pharmacother2019Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46.OXPHOS
LEAK
N
S
NS
ROX
Isolated mitochondriaRatLiver
Chabi 2019 MitoFit Preprint Arch EA2019Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. https://doi.org/10.26124/mitofit:ea19.MitoEAGLE.0001LEAK
OXPHOS
ET
N
S
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Permeabilized tissueHumanSkeletal muscle
Lauridsen 2019 Mitochondrion2019Lauridsen PE, Rasmussen LJ, Desler C (2019) Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. Mitochondrion 47:47-53.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Kirby 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Kirby AR, Cox GK, Nelson D, Heuer RM, Stieglitz JD, Benetti DD, Grosell M, Crossley DA 2nd (2019) Acute crude oil exposure alters mitochondrial function and ADP affinity in cardiac muscle fibers of young adult Mahi-mahi (Coryphaena hippurus). Comp Biochem Physiol C Toxicol Pharmacol 218:88-95.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueFishesHeart
Goldberg 2019 Biochem J2019Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2019) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.LEAK
ET
F
N
S
NS
Other combinations
ROX
Isolated mitochondriaMouseHeart
Deutschman 2019 J Cell Sci2019Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Fisar 2019 Clin Biochem2019Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80.LEAK
OXPHOS
ET
N
S
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ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Azevedo 2019 Food Chem Toxicol2019Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol 132:110694.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissueRatLiver
Braz-De-Melo 2019 Sci Rep2019Braz-De-Melo HA, Pasquarelli-do-Nascimento G, Corrêa R, das Neves Almeida R, de Oliveira Santos I, Prado PS, Picolo V, de Bem AF, Pizato N, Magalhães KG (2019) Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Sci Rep 9:20119.LEAK
ET
ROXIntact cellsHumanNeuroblastoma
Dent 2019 J Appl Physiol (1985)2019Dent JR, Hetrick B, Tahvilian S, Sathe A, Greyslak K, LaBarge SA, Svensson K, McCurdy CE, Schenk S (2019) Skeletal muscle mitochondrial function and exercise capacity is not impaired in mice with knockout of STAT3. J Appl Physiol (1985) 127:1117-27.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Ma 2019 Biochem Biophys Res Commun2019Ma T, Lin S, Wang B, Wang Q, Xia W, Zhang H, Cui Y, He C, Wu H, Sun F, Zhao Z, Gao P, Zhu Z, Liu D (2019) TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction. Biochem Biophys Res Commun 519:674-81.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseHeart
Miranda-Silva 2019 Acta Physiologica2019Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378.LEAK
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Intact organ
Permeabilized tissue
Isolated mitochondria
RatHeart
Berg 2019 Front Physiol2019Berg J, Undebakke V, Rasch-Halvorsen Ø, Aakerøy L, Sandbakk Ø, Tjønna AE (2019) Comparison of mitochondrial respiration in M. triceps brachii and M. vastus lateralis between elite cross-country skiers and physically active controls. Front Physiol 10:365.LEAK
OXPHOS
ET
F
N
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NS
ROX
Permeabilized tissueHumanSkeletal muscle
Gonzalez-Armenta 2019 J Nutr2019Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr 149:1493-502.LEAK
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F
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Permeabilized tissueOther mammalsSkeletal muscle
Kumari 2019 Am J Physiol Heart Circ Physiol2019Kumari S, Braun RK, Tetri L, Barton GP, Hacker TA, Goss KN (2019) Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart. Am J Physiol Heart Circ Physiol 317:H1272-81.LEAK
OXPHOS
ET
N
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CIV
ROX
Permeabilized tissueRatHeart
McManus 2019 Cell Metab2019McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90.LEAK
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N
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Isolated mitochondriaMouseHeart