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Property "Has-20abstract" (as page type) with input value "-5B-5BFile:01.jpg-7Cright-7C150px-7CSameh-20Ali-5D-5D-0AMany-20neurodegenerative,-20cardiovascular,-20cancer,-20and-20psychological-20disorders-20are-20known-20to-20involve-20mitochondrial-20dysfunction-20and-20deregulated-20levels-20of-20reactive-20oxygen-20species.-20Aging-20is-20associated-20with-20a-20sustained-20increase-20in-20superoxide-20radical-20levels,-20which-20is-20associated-20with-20a-20progressive-20decline-20in-20cognitive-20function-20and-20increased-20prevalence-20of-20neurodegeneration.-20Mitochondria-20were-20identified-20as-20one-20source-20of-20oxidant-20production-20in-20brain-20during-20aging,-20but-20several-20recent-20studies-20suggest-20that-20an-20alternative,-20extra-2Dmitochondrial-20source-20of-20superoxide-20may-20also-20be-20important-20to-20aging-2Dassociated-20pathologic-20phenotype.-20-20In-20this-20presentation-20I-20will-20briefly-20discuss-20some-20of-20our-20contributions-20to-20the-20field-20including-20our-20studies-20on-20the-20dynamics-20of-20mitochondrial-20superoxide-20production,-20and-20our-20recent-20discovery-20that-20the-20superoxide-2Dproducing-20enzyme-20NADPH-2Doxidase-2D2-20(Nox2)-20is-20induced-20during-20aging-20and-20remain-20constitutively-20active-20in-20neurons-20and-20synaptosomes-20from-20aged-20brain-20and-20from-20schizophrenia-20mouse-20model.-0A-0AFinally,-20Iโ€™ll-20present-20our-20progress-20in-20establishing-20the-20Center-20for-20Aging-20and-20Associated-20Diseases-20(CAAD)-20as-20part-20of-20the-20newly-20founded-20Zewail-20City-20of-20Science-20and-20Technology,-20the-20Egyptian-20National-20Project-20of-20Scientific-20Renaissance.-20In-20CAAD,-20we-20are-20focusing-20primarily-20on-20establishing-20a-20state-2Dof-2Dthe-2Dart-20facility-20to-20study-20diseases-20in-20relevance-20to-20the-20Egyptian-20people.-20In-20one-20of-20CAADโ€™s-20core-20facilities,-20the-20Oroborosยฎ-20O2k-2DMultiSensor-20system-20will-20be-20combined-20with-20the-20Seahorse-20XF24-20and-20the-20Magnettech-20MS400-20EPR-20spectrometer-20to-20study-20mitochondrial-20dynamics-20in-20the-20context-20of-20aging,-20metabolic,-20cardiovascular,-20and-20neurodegenerative-20diseases.-0A-23-20-5Bhttp:-2F-2Fwww.ncbi.nlm.nih.gov-2Fpubmed-3Fterm=Ali-252C-2520SS-252C-2520Marcondes-252C-2520MC-252C-2520Bajova-252C-2520H-252C-2520and-2520Conti-252C-2520B-20Ali-20SS,-20Marcondes-20MC,-20Bajova-20H,-20Dugan-20LL,-20Conti-20B-20(2010)-20Metabolic-20depression-20and-20increased-20reactive-20oxygen-20species-20production-20by-20isolated-20mitochondria-20at-20moderately-20lower-20temperatures-20J-20Biol-20Chem-20285:-2032522-2D32528.-20Open-20Access-5D-0A-23-20-5Bhttp:-2F-2Fwww.ncbi.nlm.nih.gov-2Fpubmed-3Fterm=Initial-2520evidence-2520linking-2520synaptic-2520superoxide-2520production-2520with-2520poor-2520short-2Dterm-2520memory-2520in-2520aged-2520mice-20Ali-20SS,-20Young-20JW,-20Wallace-20CK,-20Gresack-20J,-20Jeste-20DV,-20Geyer-20MA,-20Dugan-20LL,-20Risbrough-20VB-20(2011)-20Initial-20evidence-20linking-20synaptic-20superoxide-20production-20with-20poor-20short-2Dterm-20memory-20in-20aged-20mice.-20Brain-20Res-201368:-2065-2D70.-20Open-20Access-5D-0A-23-20-5Bhttp:-2F-2Fwww.ncbi.nlm.nih.gov-2Fpubmed-3Fterm=Mitochondria-2Dlocalized-2520caveolin-2520in-2520adaptation-2520tro-2520cellular-2520stress-2520and-2520injury-20Fridolfsson-20HN,-20Kawaraguchi-20Y,-20Ali-20SS,-20Panneerselvam-20M,-20Niesman-20IR,-20Finley-20JC,-20Kellerhals-20SE,-20Migita-20MY,-20Okada-20H,-20Moreno-20AL,-20Jennings-20M,-20Kidd-20MW,-20Bonds-20JA,-20Balijepalli-20RC,-20Ross-20RS,-20Patel-20PM,-20Miyanohara-20A,-20Chen-20Q,-20Lesnefsky-20EJ,-20Head-20BP,-20Roth-20DM,-20Insel-20PA,-20Patel-20HH-20(2012)-20Mitochondria-2Dlocalized-20caveolin-20in-20adaptation-20to-20cellular-20stress-20and-20injury.-20FASEB-20J-2026:-204637-2D4649.-20Open-20Access-5D" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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