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Property "Has-20abstract" (as page type) with input value "-5B-5BFile:Mark-20Felix.jpg-7Cright-7C150px-7CFelix-20Mark-5D-5D-0AOngoing-20ocean-20warming-20and-20acidification-20have-20been-20found-20to-20particularly-20affect-20polar-20marine-20ecosystems.-20However,-20few-20data-20exist-20about-20the-20ability-20of-20Antarctic-20fish-20to-20respond-20to-20environmental-20change.-20While-20whole-20animal-20and-20transcriptomic-20data-20on-20the-20effects-20of-20ocean-20acidification-20and-20warming-20exist-20for-20fish,-20the-20acclimation-20capacities-20of-20the-20subcellular,-20organelle-20levels-20have-20been-20poorly-20studied-20in-20this-20respect.-20-0ADiffusion-20of-20CO-3Csub-3E2-3C-2Fsub-3E-20into-20the-20bloodstream-20and-20into-20the-20intracellular-20milieu-20in-20aquatic-20water-20breathing-20organisms-20leads-20to-20an-20acidification-20of-20body-20fluids.-20Fish-20can-20regulate-20extracellular-20and-20intracellular-20pH-20by-20actively-20accumulating-20bicarbonate-20to-20compensate-20for-20the-20acidification-20of-20the-20extracellular-20and-20intracellular-20milieu.-20However,-20chronically-20elevated-20bicarbonate-20levels-20may-20interfere-20with-20a-20variety-20of-20metabolic-20processes.-20For-20example,-20bicarbonate-20is-20known-20to-20strongly-20interact-20with-20mitochondrial-20metabolism,-20among-20others-20it-20competitively-20inhibits-20citrate-20oxidation,-20ultimately-20influencing-20ET-20capacities.-0AWe-20therefore-20studied-20the-20capacities-20for-20mitochondrial-20acclimation-20towards-20elevated-20PCO-3Csub-3E2-3C-2Fsub-3E-20and-20bicarbonate-20levels-20in-20fish-20that-20were-20incubated-20at-20different-20water-20PCO-3Csub-3E2-3C-2Fsub-3E.-20We-20studied-20ET-20capacities-20in-20permeabilised-20heart-20fibres-20in-20fish-2DMiR06,-20modified-20to-20contain-20different-20levels-20of-20-5BHCO-3Csub-3E3-3C-2Fsub-3E-3Csup-3E-2D-3C-2Fsup-3E-5D,-20and-20enzymatic-20activies-20of-20citrate-20synthase-20and-20cytochrome-20c-20oxidase.-20We-20found-20a-20strong-20influence-20of-20bicarbonate-20on-20mitochondrial-20metabolism-20and-20a-20compensatory-20increase-20of-20mitochondrial-20capacities-20after-20hypercapnia-20acclimation.-20Our-20findings-20illustrate-20the-20importance-20of-20adjusting-20bicarbonate-20levels-20to-20represent-20intracellular-20conditions-20in-20fish-20and-20other-20aquatic-20organisms.-0A-0A-23-20-5Bhttp:-2F-2Fwww.ncbi.nlm.nih.gov-2Fpubmed-2F6018760-20Simpson-20DP-20(1967)-20Regulation-20of-20renal-20citrate-20metabolism-20by-20bicarbonate-20ion-20and-20pH:-20observations-20in-20tissue-20slices-20and-20mitochondria.-20J-20Clin-20Invest-2046:-20225-2D238.-20Open-20Access-5D-0A-23-20-5Bhttp:-2F-2Fwww.ncbi.nlm.nih.gov-2Fpubmed-2F23075125-20Strobel-20A,-20Bennecke-20S,-20Leo-20E,-20Mintenbeck-20K,-20Poertner-20HO,-20Mark-20FC-20(2012)-20Metabolic-20shifts-20in-20the-20Antarctic-20fish-20-27-27Notothenia-20rossii-27-27-20in-20response-20to-20rising-20temperature-20and-20PCO-3Csub-3E2-3C-2Fsub-3E.-20Front-20Zool-209:-2028.-20Open-20Access-5D" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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