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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0A-0AMitochondrial-20alterations-20are-20evident-20in-20various-20neurological-20diseases-3B-20and-20most-20notably,-20in-20the-20earliest-20presymptomatic-20stages-20of-20Alzheimers-20Disease-20(AD)-20pathology-5B1-5D.-20As-20a-20result,-20brain-20bioenergetics-20have-20emerged-20as-20an-20important-20topic-20of-20research.-20AD-20is-20associated-20with-20changes-20in-20brain-20pathology-20that-20manifest-20in-20specific-20brain-20regions,-20such-20as-20the-20frontal-20cortex-20and-20hippocampus.-20-20Therefore,-20our-20goal-20was-20to-20selectively-20examine-20the-20bioenergetic-20profiles-20of-20brain-20mitochondria-20isolated-20from-20distinct-20regions-20relevant-20to-20AD.-0A-0AOur-20approach-20utilized-20cynomolgus-20macaques-20as-20they-20have-20been-20demostrated-20to-20be-20reliable-20models-20for-20evaluating-20various-20age-20related-20diseases-20and-20conditions-5B2-5D.-20In-20addition,-20the-20use-20of-20non-2Dhuman-20primates-20provides-20sufficient-20tissue-20for-20adequate-20mitochondrial-20yield-20from-20multiple-20brain-20regions-20as-20shown-20in-20-27-27'Figure-201-27-27'.-20We-20analyzed-20isolated-20mitochondria-20from-20prefrontal-20cortex,-20entorhinal-20cortex,-20and-20cerebellum-20from-20the-20same-20animal-20to-20determine-20how-20bioenergetic-20profiles-20may-20differ-20between-20these-20areas.-20Prefrontal-20cortex-20and-20entorhinal-20cortex-20were-20selected-20due-20to-20their-20relevance-20in-20AD-20pathology,-20while-20the-20cerebellar-20region-20was-20selected-20because-20it-20may-20serve-20as-20a-20useful-20control-20region-20in-20studies-20of-20AD-20pathology.-20Mitochondria-20were-20isolated-20from-20brain-20tissue-20using-20a-20manual-20glass-2Don-2Dglass-20cell-20homogenizer-20and-20series-20of-20centrifugation-20steps.-20We-20utilized-20two-20SUIT-20protocols-20to-20examine-20respiration-20in-20high-2Dresolution:-20RP2-20and-20a-20previously-20published-20protocol-20by-20Lanza-20and-20Nair-5B3-5D.-20RP2-20was-20selected-20because-20it-20is-20a-20standard-20reference-20protocol-3B-20thus,-20the-20methods-20have-20been-20well-20vetted-20and-20the-20results-20are-20easily-20interpreted.-20We-20were-20also-20interested-20in-20RP2-20because-20it-20includes-20titrations-20to-20evaluate-20fatty-20acid-20oxidation.-20The-20protocol-20published-20by-20Lanza-20and-20Nair-20was-20applied-20because-20it-20offers-20an-20alternative-20approach-20that-20has-20been-20adopted-20by-20other-20research-20groups.-20By-20using-20two-20protocols-20we-20can-20compare-20to-20tease-20out-20additional-20information-20that-20one-20protocol-20alone-20may-20miss.-20Traces-20from-20the-20two-20protocols-20can-20be-20observed-20in-20-27-27'Figure-202-27-27'." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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