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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0AAn-20ischemic-20insult-20is-20associated-20with-20increased-20circulating-20fatty-20acids-20(FA)-20due-20to-20an-20adrenergic-20activation-20of-20adipose-20tissue-20lipolysis.-20Therefore,-20hearts-20will-20not-20only-20be-20challenged-20by-20hypoxia,-20but-20also-20by-20an-20acute-20FA-2Dload,-20which-20has-20been-20shown-20to-20induce-20adverse-20cardiac-20effects-20such-20as-20mitochondrial-20dysfunction,-20oxidative-20stress,-20oxygen-20wasting-20and-20inefficiency.-20Although-20obesity-20is-20a-20contributing-20factor-20to-20the-20development-20of-20type-202-20diabetes-20and-20heart-20failure-20it-20remains-20unclear-20if-20and-20how-20obesity-2Dassociated-20chronic-20hyperlipidemia-20affects-20the-20cardiac-20response-20to-20an-20acute-20FA-2Dload.-20Thus,-20we-20have-20examined-20the-20effect-20of-20high-20FA-20on-20hearts-20from-20a-20murine-20model-20of-20obesity.-0A-0ADiet-2Dinduced-20obesity-20(DIO)-20was-20obtained-20by-20feeding-205-2Dwk-20old-20male-20C57BL-2F6J-20mice-20obesogenic-20diet-20for-2020-20wks.-20Age-2Dmatched-20chow-2Dfed-20mice-20were-20included-20as-20controls-20(CON).-20-27-27Ex-20vivo-27-27-20left-20ventricular-20(LV)-20function-20(working-20heart-20perfusions,-20n=8-2D11)-20and-20ischemic-20susceptibility-20(LV-20post-2Dischemic-20functional-20recovery-20and-20infarct-20size,-20Langendorff-20perfusions,-20n=12-2D15)-20were-20examined-20in-20hearts-20exposed-20to-20normal-20(0.35-20mM)-20or-20high-20(1.8-20mM)-20palmitate-20levels.-20We-20also-20assessed-20myocardial-20O-3Csub-3E2-3C-2Fsub-3E-20consumption-20(MVO-3Csub-3E2-3C-2Fsub-3E),-20FA-20oxidation-20and-20mechanical-20efficiency-20(n=12-2D15),-20as-20well-20as-20myocardial-20ROS-20content-20(DHE-20tissue-20staining)-20and-20mitochondrial-20respiration-20(high-2Dresolution-20respirometry,-20-27-27n-27-27=6-2D8).-0A-0ADIO-20mice-20demonstrated-20elevated-20plasma-20FA-20levels-20(0.37±0.03-20vs-200.58±0.04-20mM,-20p-3C0.01)-20and-20insulin-20resistance-20(4.4-20fold-20higher-20HOMA-2DIR).-20They-20also-20developed-20diastolic-20dysfunction-20with-20only-20a-20mild-20systolic-20dysfunction.-20High-20FA-20perfusion-20did-20not-20alter-20LV-20function-20in-20neither-20CON-20nor-20DIO-20hearts.-20However,-20elevated-20FA-20decreased-20mechanical-20efficiency-20(due-20to-20increased-20MVO-3Csub-3E2-3C-2Fsub-3E,-2028±2-20vs-2037±2-20μmol-2Fmin-2Fg,-20p-3C0.01),-20induced-20oxidative-20stress-20and-20reduced-20mitochondrial-20OXPHOS-20rate-20and-20coupling-20(RCR)-20in-20CON-20hearts.-20These-20FA-2Dmediated-20changes-20were-20not-20found-20in-20DIO-20hearts.-20Furthermore,-20in-20contrast-20to-20CON-20hearts-20(where-20ischemic-20tolerance-20was-20not-20altered-20by-20the-20FA-2Dload),-20DIO-20hearts-20exposed-20to-20high-20FA-20levels-20showed-20increased-20functional-20recovery-20(53±5-20vs-2036±5-20-25-20Rate-2DPressure-2DProduct,-20p-3C0.01)-20and-20decreased-20infarct-20size-20(47±2-20vs-2062±5-25,-20p-3C0.02).-20This-20cardioprotective-20effect-20was-20corroborated-20in-20hearts-20from-20obese,-20type-202-20diabetic-20(db-2Fdb)-20mice-20(54±6-20vs-2036±5-20-25-20recovery-20of-20RPP,-20p-3C0.05,-20and-2055±5-20vs72±2-20-25-20infarction,-20p-3C0.01,-20respectively).-0A-0AThis-20study-20shows-20that-20hearts-20from-20obese-2Fdiabetic-20mice-20are-20resistant-20to-20the-20adverse-20effects-20an-20acute-20FA-2Dload.-20Although-20dyslipidemia-20plays-20a-20role-20in-20the-20development-20of-20obesity-2Fdiabetes-2Dmediated-20heart-20failure,-20we-20suggest-20that-20these-20hearts-20undergo-20adaptive-20changes-20where-20elevated-20FA-20levels-20exert-20cardioprotection." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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